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Exosc3 Gene Detail
Summary
  • Symbol
    Exosc3
  • Name
    exosome component 3
  • Synonyms
    2310005D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913612
    NCBI Gene: 66362
  • Gene Overview
    MyGene.info: EXOSC3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:45316629-45320603 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.84 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913612
protein coding gene Chr4:45316613-45342732 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028243
protein coding gene Chr4:43545988-43573215 (-)
A/J MGP_AJ_G0028201
protein coding gene Chr4:41986292-42012444 (-)
AKR/J MGP_AKRJ_G0028152
protein coding gene Chr4:42986008-43013182 (-)
BALB/cJ MGP_BALBcJ_G0028221
protein coding gene Chr4:42065507-42092297 (-)
C3H/HeJ MGP_C3HHeJ_G0027942
protein coding gene Chr4:43591680-43618151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028662
protein coding gene Chr4:45186246-45212363 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025971
protein coding gene Chr4:39375526-39402673 (-)
CAST/EiJ MGP_CASTEiJ_G0027382
protein coding gene Chr4:43139827-43166030 (-)
CBA/J MGP_CBAJ_G0027908
protein coding gene Chr4:46591747-46619655 (-)
DBA/2J MGP_DBA2J_G0028058
protein coding gene Chr4:41881140-41907200 (-)
FVB/NJ MGP_FVBNJ_G0028025
protein coding gene Chr4:41112657-41138715 (-)
LP/J MGP_LPJ_G0028157
protein coding gene Chr4:43595004-43621121 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028049
protein coding gene Chr4:49734553-49760531 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028697
protein coding gene Chr4:43199752-43225888 (-)
PWK/PhJ MGP_PWKPhJ_G0027106
protein coding gene Chr4:41953755-41978000 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026934
protein coding gene Chr4:42705409-42733393 (-)
WSB/EiJ MGP_WSBEiJ_G0027459
protein coding gene Chr4:43090381-43117422 (-)



Homology
more
  • Human Ortholog
    EXOSC3, exosome component 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXOSC3, exosome component 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA3J10.7, CGI-102, hRrp-40, p10, PCH1B, RRP40, Rrp40p
  • Links
    NCBI Gene ID: 51010
    neXtProt AC: NX_Q9NQT5
    UniProt: Q9NQT5

  • Chr Location
    9p13.2; chr9:37779714-37785092 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6867
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EXOSC3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human EXOSC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional ready allele appear phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66362 NCBI Gene Model | MGI Sequence Detail 3975 C57BL/6J ±  kb
transcript NM_025513 RefSeq | MGI Sequence Detail 1064 C57BL/6  
polypeptide Q7TQK4 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 40

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140337
References
more
  • Summaries
    All 38
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:241502 Lim J, et al., Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry. Cell. 2017 Apr 20;169(3):523-537.e15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory