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Exosc3
Gene Detail
Symbol

Name
ID
Exosc3
exosome component 3
MGI:1913612
Synonyms
2310005D06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
23.84 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:45316613-45342732 bp, - strand
From VEGA annotation of GRCm38

  26120 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EXOSC3
Gene Tree: Exosc3

Human
homologs
EXOSC3, exosome component 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51010
neXtProt AC: NX_Q9NQT5

Human Synonyms: bA3J10.7, CGI-102, hRrp-40, p10, PCH1B, RRP40, Rrp40p

Human Chr (Location): 9p11; chr9:37779714-37785092 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EXOSC3

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Exosc3 interacts with 77 markers (Mir7-1, Mir16-1, Mir98, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process CUT catabolic process, DNA deamination, ...
Component cytoplasm, cytoplasmic exosome (RNase complex), ...
Function 3'-5'-exoribonuclease activity, 5'-3' exoribonuclease activity, ...
External Resources: FuncBase
Expression
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase exosc3    NEW 
Molecular
reagents
All nucleic(39) cDNA(39)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000007603 (Evidence)
Ensembl Gene Model ENSMUSG00000028322 (Evidence)
Entrez Gene 66362 (Evidence)
UniGene 275788
DFCI TC1578839, TC1601406
DoTS DT.495052, DT.55168915
NIA Mouse Gene Index U025020
EC 3.1.13.-
Consensus CDS Project CCDS18136.1
International Mouse Phenotyping Consortium Status Exosc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007603 VEGA Gene Model | MGI Sequence Detail 26120 C57BL/6J ±  kb
transcript OTTMUST00000017455 VEGA | MGI Sequence Detail 1077 Not Applicable 
polypeptide OTTMUSP00000008050 VEGA | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(205 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026699 Exosome complex RNA-binding protein 1/RRP40/RRP4
InterPro IPR004088 K Homology domain, type 1
InterPro IPR012340 Nucleic acid-binding, OB-fold
Protein Ontology PR:000007260 exosome complex component RRP40
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
All references(34)
Other
accession IDs
MGI:2140337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory