Dpy30 MGI Mouse Gene Detail - MGI:1913560 - dpy-30, histone methyltransferase complex regulatory subunit

Dpy30 Gene Detail

Symbol

Dpy30
Name

dpy-30, histone methyltransferase complex regulatory subunit
Synonyms

2810410M20Rik

Feature Type

protein coding gene
IDs

MGI:1913560
NCBI Gene: 66310

Sequence Map

Chr17:74299474-74323944 bp, - strand
From NCBI annotation of GRCm38

Mouse Genome Browser
Download
Sequence

24471 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 45.64 cM
Mapping Data

2 experiments

Human Ortholog

DPY30, dpy-30, histone methyltransferase complex regulatory subunit

Vertebrate Orthologs

10

Human Ortholog

DPY30, dpy-30, histone methyltransferase complex regulatory subunit
Orthology source: HomoloGene, HGNC
Synonyms

Cps25, HDPY-30, Saf19
Links

HGNC:24590

NCBI Gene ID: 84661

neXtProt AC: NX_Q9C005

UniProt: Q9C005
Chr Location

2p22.3; chr2:32011649-32039840 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 32582
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DPY30
Gene Tree

Dpy30

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

149
Gene trapped

145
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

55 strains or lines available

Embryos homozygous for a knock-out allele die between E7.5 and E9.5 exhibiting abnormal post-implantation development associated with absence of the primitive streak and impaired gastrulation of the pluripotent epiblast.

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All GO Annotations

17
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

122
Tissues

16
cDNA Data

82
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dpy30

ZFIN dpy30

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Dpy30 interacts with 77 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

30
RefSeq

8
UniProt

2
CCDS

CCDS28970.1
UniGene

28536

Ensembl

ENSMUSG00000024067 (Evidence)
NCBI Gene

66310

			Length	Strain/Species	Flank
genomic	66310	NCBI Gene Model \| MGI Sequence Detail	24471	C57BL/6J	± kb
transcript	NM_024428	RefSeq \| MGI Sequence Detail	799	C57BL/6
polypeptide	Q99LT0	UniProt \| EBI \| MGI Sequence Detail	99	Not Applicable

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SNPs within 2kb

141 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000006677 protein dpy-30

(term hierarchy)
InterPro Domains

IPR007858 Dpy-30 motif

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All nucleic 82

cDNA 82

Microarray probesets 3

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MGI:2147150

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:237262 Yang Z, et al., Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells. J Exp Med. 2016 Oct 17;213(11):2349-2364

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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