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Mplkip Gene Detail
Summary
  • Symbol
    Mplkip
  • Name
    M-phase specific PLK1 intereacting protein
  • Synonyms
    2810021B07Rik, C330007M08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913558
    NCBI Gene: 66308
  • Gene Overview
    MyGene.info: MPLKIP
Location & Maps
more
  • Sequence Map
    Chr13:17695413-17699105 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3693 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 6.05 cM, cytoband A3.1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MPLKIP, M-phase specific PLK1 interacting protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MPLKIP, M-phase specific PLK1 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABHS, C7orf11, ORF20, TTD4
  • Links
    NCBI Gene ID: 136647
    neXtProt AC: NX_Q8TAP9

  • Chr Location
    7p14.1; chr7:40132743-40134652 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MPLKIP associations

Human Disease Mouse Models
       Trichothiodystrophy 4, Nonphotosensitive; TTD4   OMIM: 234050
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Gene trapped
    19
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Mplkip
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66308 NCBI Gene Model | MGI Sequence Detail 3693 C57BL/6J ±  kb
transcript NM_025479 RefSeq | MGI Sequence Detail 2672 C57BL/6  
polypeptide Q9D011 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016784 M-phase-specific PLK1-interacting protein
  • InterPro Domains
    IPR028265 M-phase-specific PLK1-interacting protein-like
    IPR026618 M-phase-specific PLK1-interacting protein-like, vertebrate
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924888
References
more
  • Summaries
    All 30
    Gene Ontology 2
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory