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Gkn1 Gene Detail
Summary
  • Symbol
    Gkn1
  • Name
    gastrokine 1
  • Synonyms
    2200002K21Rik, AMP-18, BRICD1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913533
    NCBI Gene: 66283
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:87322635-87327897 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.96 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913533
 protein coding gene Chr6:87322632-87327924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030989
 protein coding gene Chr6:88696268-88701561 (-)
A/J MGP_AJ_G0030955
 protein coding gene Chr6:85265606-85270937 (-)
AKR/J MGP_AKRJ_G0030886
 protein coding gene Chr6:87735928-87741222 (-)
BALB/cJ MGP_BALBcJ_G0030968
 protein coding gene Chr6:85267139-85272433 (-)
C3H/HeJ MGP_C3HHeJ_G0030742
 protein coding gene Chr6:96738487-96743780 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031425
 protein coding gene Chr6:91081206-91086498 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028609
 protein coding gene Chr6:83447080-83452186 (-)
CAST/EiJ MGP_CASTEiJ_G0030077
 protein coding gene Chr6:87806443-87811725 (-)
CBA/J MGP_CBAJ_G0030652
 protein coding gene Chr6:94623476-94628769 (-)
DBA/2J MGP_DBA2J_G0030808
 protein coding gene Chr6:84571594-84576887 (-)
FVB/NJ MGP_FVBNJ_G0030761
 protein coding gene Chr6:83752127-83757420 (-)
LP/J MGP_LPJ_G0030885
 protein coding gene Chr6:88709057-88714350 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030794
 protein coding gene Chr6:98739013-98744306 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031452
 protein coding gene Chr6:87578295-87583588 (-)
PWK/PhJ MGP_PWKPhJ_G0029792
 protein coding gene Chr6:83533766-83539099 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029620
 protein coding gene Chr6:86394311-86401164 (-)
WSB/EiJ MGP_WSBEiJ_G0030158
 protein coding gene Chr6:88035980-88041274 (-)



Homology
more
  • Human Ortholog
    GKN1, gastrokine 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GKN1, gastrokine 1
  • Synonyms
    AMP18, BRICD1, CA11, FOV, foveolin
  • Links
    NCBI Gene ID: 56287
    neXtProt AC: NX_Q9NS71
    UniProt: Q9NS71

  • Chr Location
    2p13.3; chr2:68974573-68980980 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    14
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66283 NCBI Gene Model | MGI Sequence Detail 5263 C57BL/6J ±  kb
    transcript NM_025466 RefSeq | MGI Sequence Detail 1220 C57BL/6  
    polypeptide Q9CR36 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 16

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:322734 Steiner S, et al., De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Oncogene. 2022 Mar;41(10):1507-1517
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory