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Tmem126a Gene Detail
Summary
  • Symbol
    Tmem126a
  • Name
    transmembrane protein 126A
  • Synonyms
    1810020E01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913521
    NCBI Gene: 66271
  • Gene Overview
    MyGene.info: TMEM126A
Location & Maps
more
  • Sequence Map
    Chr7:90450700-90457229 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6530 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 50.59 cM, cytoband E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TMEM126A, transmembrane protein 126A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM126A, transmembrane protein 126A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OPA7
  • Links
    NCBI Gene ID: 84233
    neXtProt AC: NX_Q9H061

  • Chr Location
    11q14.1; chr11:85647919-85656553 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TMEM126A associations

Human Disease Mouse Models
       Optic Atrophy 7 with or without Auditory Neuropathy; OPA7   OMIM: 612989
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotype references
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    3
  • Targeted
    5
  • Genomic Mutations
    4 involving Tmem126a
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031242 VEGA Gene Model | MGI Sequence Detail 6530 C57BL/6J ±  kb
transcript OTTMUST00000077392 VEGA | MGI Sequence Detail 799 Not Applicable  
polypeptide OTTMUSP00000040921 VEGA | MGI Sequence Detail 196 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000032736 transmembrane protein 126A
  • InterPro Domains
    IPR009801 Transmembrane protein 126
Molecular
Reagents
less
  • All nucleic 64
    cDNA 64

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 34
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201630 Ryder E, et al., Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome. 2013 Aug;24(7-8):286-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory