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Retreg1 Gene Detail
Summary
  • Symbol
    Retreg1
  • Name
    reticulophagy regulator 1
  • Synonyms
    1810015C04Rik, Fam134b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913520
    NCBI Gene: 66270
Location & Maps
more
  • Sequence Map
    Chr15:25843298-25973696 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      130399 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 9.59 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RETREG1, reticulophagy regulator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RETREG1, reticulophagy regulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAM134B, JK1, JK-1
  • Links
    NCBI Gene ID: 54463
    neXtProt AC: NX_Q9H6L5
    UniProt: Q9H6L5

  • Chr Location
    5p15.1; chr5:16473038-16617058 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RETREG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased thermal nociceptive threshold and sensory neuron degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66270 NCBI Gene Model | MGI Sequence Detail 130399 C57BL/6J ±  kb
transcript NM_001277315 RefSeq | MGI Sequence Detail 3228 C57BL/6  
polypeptide Q8VE91 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    617 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146123
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:222922 Khaminets A, et al., Regulation of endoplasmic reticulum turnover by selective autophagy. Nature. 2015 Jun 18;522(7556):354-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory