About   Help   FAQ
Retreg1 Gene Detail
Summary
  • Symbol
    Retreg1
  • Name
    reticulophagy regulator 1
  • Synonyms
    1810015C04Rik, Fam134b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913520
    NCBI Gene: 66270
  • Alliance
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:25843298-25973696 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 9.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    617 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913520
protein coding gene Chr15:25843180-25973696 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021751
protein coding gene Chr15:23851477-23989931 (+)
A/J MGP_AJ_G0021711
protein coding gene Chr15:22950967-23081041 (+)
AKR/J MGP_AKRJ_G0021689
protein coding gene Chr15:23454219-23593850 (+)
BALB/cJ MGP_BALBcJ_G0021718
protein coding gene Chr15:22932641-23064513 (+)
C3H/HeJ MGP_C3HHeJ_G0021494
protein coding gene Chr15:23501194-23633160 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022157
protein coding gene Chr15:24877518-25018961 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019697
protein coding gene Chr15:21264680-21394923 (+)
CAST/EiJ MGP_CASTEiJ_G0021010
protein coding gene Chr15:23862670-24002505 (+)
CBA/J MGP_CBAJ_G0021463
protein coding gene Chr15:25688374-25822286 (+)
DBA/2J MGP_DBA2J_G0021587
protein coding gene Chr15:22720198-22851751 (+)
FVB/NJ MGP_FVBNJ_G0021565
protein coding gene Chr15:22280410-22413948 (+)
LP/J MGP_LPJ_G0021655
protein coding gene Chr15:23713947-23849468 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021590
protein coding gene Chr15:28378094-28512491 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022180
protein coding gene Chr15:23650315-23785857 (+)
PWK/PhJ MGP_PWKPhJ_G0020753
protein coding gene Chr15:22860822-22997527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020591
protein coding gene Chr15:23464494-23607928 (+)
WSB/EiJ MGP_WSBEiJ_G0021066
protein coding gene Chr15:23655138-23790643 (+)



Homology
more
  • Human Ortholog
    RETREG1, reticulophagy regulator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RETREG1, reticulophagy regulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAM134B, JK1, JK-1
  • Links
    NCBI Gene ID: 54463
    neXtProt AC: NX_Q9H6L5
    UniProt: Q9H6L5

  • Chr Location
    5p15.1; chr5:16473038-16617058 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human RETREG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased thermal nociceptive threshold and sensory neuron degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66270 NCBI Gene Model | MGI Sequence Detail 130399 C57BL/6J ±  kb
transcript NM_001277315 RefSeq | MGI Sequence Detail 3228 C57BL/6  
polypeptide Q8VE91 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146123
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:249176 Moretti J, et al., STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell. 2017 Nov 02;171(4):809-823.e13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/22/2019
MGI 6.14
The Jackson Laboratory