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Retreg1 Gene Detail
Summary
  • Symbol
    Retreg1
  • Name
    reticulophagy regulator 1
  • Synonyms
    1810015C04Rik, Fam134b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913520
    NCBI Gene: 66270
  • Alliance
    genome feature page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:25843266-25973773 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 9.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4154 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913520
 protein coding gene Chr15:25840795-25973782 (+)
129S1/SvImJ ENSMUSG00200026892
 protein coding gene Chr15:22852451-22982947 (+)
A/J ENSMUSG00195013604
 protein coding gene Chr15:22806277-22936804 (+)
AKR/J ENSMUSG00220023905
 protein coding gene Chr15:22651096-22781633 (+)
BALB/cJ ENSMUSG00180005365
 protein coding gene Chr15:22734811-22865324 (+)
C3H/HeJ ENSMUSG00175004447
 protein coding gene Chr15:22869365-22999841 (+)
C57BL/6NJ ENSMUSG00215004685
 protein coding gene Chr15:22790895-22921410 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019697
 protein coding gene Chr15:21264680-21394923 (+)
CAST/EiJ ENSTCUG00005014820
 protein coding gene Chr15:22849515-22979194 (+)
CBA/J ENSMUSG00210024045
 protein coding gene Chr15:22842530-22973037 (+)
DBA/2J ENSMUSG00185023543
 protein coding gene Chr15:22835102-22965614 (+)
FVB/NJ ENSMUSG00205013880
 protein coding gene Chr15:22766485-22896996 (+)
JF1/MsJ ENSUMUG00000011551
 protein coding gene Chr15:22837141-22967612 (+)
LP/J ENSMUSG00230014305
 protein coding gene Chr15:26322178-26452644 (+)
NOD/ShiLtJ ENSMUSG00190012035
 protein coding gene Chr15:22808609-22939111 (+)
NZO/HlLtJ ENSMUSG00225031654
 protein coding gene Chr15:26550923-26681416 (+)
PWK/PhJ ENSLUMG00010021118
 protein coding gene Chr15:22951635-23081937 (+)
SPRET/EiJ ENSMSPG00010022621
 protein coding gene Chr15:23373854-23504284 (+)
WSB/EiJ ENSIUOG00005020279
 protein coding gene Chr15:22848038-22978394 (+)



Homology
more
  • Human Ortholog
    RETREG1, reticulophagy regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RETREG1, reticulophagy regulator 1
  • Synonyms
    FAM134B, JK-1, JK1
  • Links
    NCBI Gene ID: 54463
    UniProt: Q9H6L5

  • Chr Location
    5p15.1; chr5:16473038-16617101 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RETREG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased thermal nociceptive threshold and sensory neuron degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    104
  • cDNA Data
    17
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022270 Ensembl Gene Model | MGI Sequence Detail 130508 C57BL/6J ±  kb
transcript ENSMUST00000022881 Ensembl | MGI Sequence Detail 3248 Not Applicable  
polypeptide ENSMUSP00000022881 Ensembl | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000031111 reticulophagy regulator 1
    (term hierarchy)
  • InterPro Domains
    IPR043384 Reticulophagy receptor 1/3
    IPR055255 Reticulophagy regulator 1, N-terminal reticulon-homology domain
    IPR057282 RETREG1-3/ARL6IP-like, N-terminal reticulon-homology domain
  • GlyGen
    Q8VE91 2 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17
    Antibodies 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146123, MGI:5897461
References
more
  • Summaries
    All 56
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 20
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:354136 Iavarone F, et al., Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo. EMBO Rep. 2024 Jul 22;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory