Ssr2 MGI Mouse Gene Detail - MGI:1913506 - signal sequence receptor, beta

Ssr2 Gene Detail

Symbol

Ssr2
Name

signal sequence receptor, beta
Synonyms

TRAPbeta

Feature Type

protein coding gene
IDs

MGI:1913506
NCBI Gene: 66256
Gene Overview

MyGene.info: SSR2

Sequence Map

Chr3:88575876-88588419 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

12544 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.88 cM
Mapping Data

2 experiments

Human Ortholog

SSR2, signal sequence receptor subunit 2

Vertebrate Orthologs

10

Human Ortholog

SSR2, signal sequence receptor subunit 2
Orthology source: HomoloGene, HGNC
Synonyms

HSD25, TLAP, TRAPB, TRAP-BETA
Links

HGNC:11324

NCBI Gene ID: 6746

neXtProt AC: NX_P43308
Chr Location

1q21-q23; chr1:156009048-156020991 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 2369
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SSR2
Protein SuperFamily

translocon-associated protein, beta subunit
Gene Tree

Ssr2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

269
Chemically induced (other)

1
Gene trapped

263
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Ssr2

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All GO Annotations

4
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

47
Tissues

24
cDNA Data

245
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase ssr2

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Ssr2 interacts with 62 markers (Mir22, Mir23a, Mir23b, ...) View All

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All Sequences

60
RefSeq

4
UniProt

6
CCDS

CCDS17480.1
UniGene

7091

			Length	Strain/Species	Flank
genomic	OTTMUSG00000052161	VEGA Gene Model \| MGI Sequence Detail	12544	C57BL/6J	± kb
transcript	OTTMUST00000131082	VEGA \| MGI Sequence Detail	620	Not Applicable
polypeptide	OTTMUSP00000070159	VEGA \| MGI Sequence Detail	185	Not Applicable

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SNPs within 2kb

36 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000015660 translocon-associated protein subunit beta
InterPro Domains

IPR008856 Translocon-associated protein subunit beta

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All nucleic 247

cDNA 245

Primer pair 1

Other 1

Microarray probesets 3

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MGI:2139666, MGI:2139881

Summaries

All 41

Developmental Gene Expression 5

Gene Ontology 2

Phenotypes 15
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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