Ssr2 MGI Mouse Gene Detail - MGI:1913506 - signal sequence receptor, beta

Symbol

Ssr2
Name

signal sequence receptor, beta
Synonyms

TRAPbeta

Feature Type

protein coding gene
IDs

MGI:1913506
NCBI Gene: 66256
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:88486915-88495727 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.88 cM
Mapping Data

2 experiments

SNPs within 2kb

290 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913506	protein coding gene	Chr3:88483183-88495727 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027403	protein coding gene	Chr3:88745719-88763016 (+)
A/J	MGP_AJ_G0027367	protein coding gene	Chr3:85751975-85766474 (+)
AKR/J	MGP_AKRJ_G0027331	protein coding gene	Chr3:87865760-87881012 (+)
BALB/cJ	MGP_BALBcJ_G0027376	protein coding gene	Chr3:85837229-85851831 (+)
C3H/HeJ	MGP_C3HHeJ_G0027118	protein coding gene	Chr3:88123084-88140583 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027822	protein coding gene	Chr3:92048831-92061935 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025174	protein coding gene	Chr3:81353758-81369167 (+)
CAST/EiJ	MGP_CASTEiJ_G0026564	protein coding gene	Chr3:88367433-88374729 (+)
CBA/J	MGP_CBAJ_G0027092	protein coding gene	Chr3:95214958-95235931 (+)
DBA/2J	MGP_DBA2J_G0027230	protein coding gene	Chr3:85235576-85248741 (+)
FVB/NJ	MGP_FVBNJ_G0027198	protein coding gene	Chr3:83509070-83517529 (+)
LP/J	MGP_LPJ_G0027339	protein coding gene	Chr3:89757823-89774709 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027218	protein coding gene	Chr3:101424872-101440786 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027881	protein coding gene	Chr3:87614368-87627311 (+)
PWK/PhJ	MGP_PWKPhJ_G0026298	protein coding gene	Chr3:85014837-85030717 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026117	protein coding gene	Chr3:86799870-86812147 (+)
WSB/EiJ	MGP_WSBEiJ_G0026646	protein coding gene	Chr3:87970424-87984460 (+)

Human Ortholog

SSR2, signal sequence receptor subunit 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSR2, signal sequence receptor subunit 2
Synonyms

HSD25, TLAP, TRAPB, TRAP-BETA
Links

HGNC:11324

NCBI Gene ID: 6746

UniProt: P43308
Chr Location

1q22; chr1:156009048-156020951 (-) GRCh38

MGI Vertebrate Homology

Ssr2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SSR2
Protein SuperFamily

TRAP_beta
Gene Tree

Ssr2

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References

1 with disease annotations

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Phenotype Summary

43 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

191
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

181
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Ssr2
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal placental labyrinth vasculature morphology, perimembraneous ventricular septal defects, abnormal forebrain morphology, and complete preweaning lethality.

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All GO Annotations

6
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

24
cDNA Data

246
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ssr2

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All Sequences

69
RefSeq

10
UniProt

6
CCDS

CCDS17480.1, CCDS89648.1, CCDS89649.1

Ensembl

ENSMUSG00000041355 (Evidence)
NCBI Gene

66256

			Length	Strain/Species	Flank
genomic	66256	NCBI Gene Model \| MGI Sequence Detail	8813	C57BL/6J	± kb
transcript	NM_025448	RefSeq \| MGI Sequence Detail	1253	C57BL/6
polypeptide	Q9CPW5	UniProt \| EBI \| MGI Sequence Detail	183	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015660 translocon-associated protein subunit beta

(term hierarchy)
InterPro Domains

IPR008856 Translocon-associated protein subunit beta
GlyGen

Q9CPW5 2 sites, 8 N-linked glycans (2 sites)

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All nucleic 248

cDNA 246

Primer pair 1

Other 1

Microarray probesets 3

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MGI:2139666, MGI:2139881

Summaries

All 56

Developmental Gene Expression 8

Diseases 1

Gene Ontology 4

Phenotypes 23
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75

TSS for Ssr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29971	Chr3:88485316-88485347 (+)	-1,583 bp
Tssr29972	Chr3:88485813-88485820 (+)	-1,098 bp
Tssr29973	Chr3:88486909-88487034 (+)	57 bp
Tssr29974	Chr3:88487164-88487171 (+)	253 bp
Tssr29975	Chr3:88491072-88491090 (+)	4,166 bp
Tssr29976	Chr3:88494195-88494208 (+)	7,287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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