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Arfgap3 Gene Detail
Summary
  • Symbol
    Arfgap3
  • Name
    ADP-ribosylation factor GTPase activating protein 3
  • Synonyms
    0610009H19Rik, 1810004P07Rik, 1810035F16Rik, 9130416J18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913501
    NCBI Gene: 66251
  • Gene Overview
    MyGene.info: ARFGAP3
Location & Maps
more
  • Sequence Map
    Chr15:83299740-83350247 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50508 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.40 cM, cytoband E3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARFGAP3, ADP ribosylation factor GTPase activating protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARFGAP3, ADP ribosylation factor GTPase activating protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARFGAP1
  • Links
    NCBI Gene ID: 26286
    neXtProt AC: NX_Q9NP61

  • Chr Location
    22q13.2; chr22:42796524-42857402 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    2
  • Genomic Mutations
    3 involving Arfgap3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054277 Ensembl Gene Model | MGI Sequence Detail 50508 C57BL/6J ±  kb
transcript ENSMUST00000067215 Ensembl | MGI Sequence Detail 2618 Not Applicable  
polypeptide ENSMUSP00000064893 Ensembl | MGI Sequence Detail 524 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    240 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001164 Arf GTPase activating protein
Molecular
Reagents
less
  • All nucleic 79
    cDNA 79

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916388, MGI:1921803, MGI:1922640
References
more
  • Summaries
    All 26
    Diseases 1
    Gene Ontology 2
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:208110 Dembla M, et al., ArfGAP3 Is a Component of the Photoreceptor Synaptic Ribbon Complex and Forms an NAD(H)-Regulated, Redox-Sensitive Complex with RIBEYE That Is Important for Endocytosis. J Neurosci. 2014 Apr 9;34(15):5245-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory