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Osgep
Gene Detail
Symbol

Name
ID
Osgep
O-sialoglycoprotein endopeptidase
MGI:1913496
Synonyms
1500019L24Rik, GCPL-1, PRSMG1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
26.30 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:50906478-50924893 bp, - strand
From VEGA annotation of GRCm38

  18416 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6395  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OSGEP
Protein SuperFamily: O-sialoglycoprotein endopeptidase
Gene Tree: Osgep

Human
homologs
OSGEP, O-sialoglycoprotein endopeptidase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55644
neXtProt AC: NX_Q9NPF4

Human Synonyms: GCPL1, KAE1, OSGEP1, PRSMG1

Human Chr (Location): 14q11.2; chr14:20447048-20455108 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from APF , CvDC )
Interactions
Osgep interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process tRNA processing, tRNA threonylcarbamoyladenosine modification
Component cytoplasm, EKC/KEOPS complex, ...
Function metal ion binding, N(6)-L-threonylcarbamoyladenine synthase, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (36)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 36
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase osgep ; ZFIN osgep    NEW 
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000033803 (Evidence)
Ensembl Gene Model ENSMUSG00000006289 (Evidence)
Entrez Gene 66246 (Evidence)
DFCI TC1575704, TC1734722, TC1673414
DoTS DT.91389085, DT.94404957, DT.491526, DT.110761680
NIA Mouse Gene Index U035517
EC 2.3.1.234
Consensus CDS Project CCDS27026.1
International Mouse Phenotyping Consortium Status Osgep
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033803 VEGA Gene Model | MGI Sequence Detail 18416 C57BL/6J ±  kb
transcript OTTMUST00000085150 VEGA | MGI Sequence Detail 2004 Not Applicable 
polypeptide OTTMUSP00000045969 VEGA | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)    SNPs within 2kb including multiple locations(149)
Protein-related
information
ResourceIDDescription
InterPro IPR000905 Gcp-like domain
InterPro IPR017861 Kae1/YgjD family
InterPro IPR017860 Peptidase M22, conserved site
Protein Ontology PR:000032666 tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory