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Hspbp1 Gene Detail
Summary
  • Symbol
    Hspbp1
  • Name
    HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
  • Synonyms
    1500019G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913495
    NCBI Gene: 66245
  • Gene Overview
    MyGene.info: HSPBP1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4660521-4685068 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 2.69 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913495
protein coding gene Chr7:4660515-4685123 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031554
protein coding gene Chr7:1578009-1608070 (-)
A/J MGP_AJ_G0031528
protein coding gene Chr7:1592203-1615887 (-)
AKR/J MGP_AKRJ_G0031457
protein coding gene Chr7:1652790-1684050 (-)
BALB/cJ MGP_BALBcJ_G0031536
protein coding gene Chr7:1634228-1660570 (-)
C3H/HeJ MGP_C3HHeJ_G0031257
protein coding gene Chr7:1630949-1657956 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031997
protein coding gene Chr7:1638731-1667051 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029121
protein coding gene Chr7:1345532-1367916 (-)
CAST/EiJ MGP_CASTEiJ_G0030621
protein coding gene Chr7:1568839-1593803 (-)
CBA/J MGP_CBAJ_G0031215
protein coding gene Chr7:1830724-1859117 (-)
DBA/2J MGP_DBA2J_G0031374
protein coding gene Chr7:1574562-1599275 (-)
FVB/NJ MGP_FVBNJ_G0031326
protein coding gene Chr7:1538070-1564398 (-)
LP/J MGP_LPJ_G0031459
protein coding gene Chr7:1693331-1719464 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031365
protein coding gene Chr7:1767006-1803731 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032027
protein coding gene Chr7:1566833-1595080 (-)
PWK/PhJ MGP_PWKPhJ_G0030349
protein coding gene Chr7:1740907-1765531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030174
protein coding gene Chr7:1620376-1643544 (-)
WSB/EiJ MGP_WSBEiJ_G0030716
protein coding gene Chr7:1582478-1610394 (-)



Homology
more
  • Human Ortholog
    HSPBP1, HSPA (Hsp70) binding protein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HSPBP1, HSPA (Hsp70) binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FES1
  • Links
    NCBI Gene ID: 23640
    neXtProt AC: NX_Q9NZL4
    UniProt: Q9NZL4

  • Chr Location
    19q13.42; chr19:55262222-55280383 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation show male infertility with an arrest of male meiosis, increased male germ cell apoptosis and azoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063802 Ensembl Gene Model | MGI Sequence Detail 24548 C57BL/6J ±  kb
transcript ENSMUST00000079970 Ensembl | MGI Sequence Detail 1593 Not Applicable  
polypeptide ENSMUSP00000078886 Ensembl | MGI Sequence Detail 357 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    cDNA 96

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:216246 Rogon C, et al., HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell. 2014 Aug 1;25(15):2260-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory