About   Help   FAQ
Dmap1 Gene Detail
Summary
  • Symbol
    Dmap1
  • Name
    DNA methyltransferase 1-associated protein 1
  • Synonyms
    1500016M21Rik, mKIAA1425
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913483
    NCBI Gene: 66233
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117531878-117539450 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.46 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913483
protein coding gene Chr4:117531878-117539470 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028652
protein coding gene Chr4:118673507-118681099 (-)
A/J MGP_AJ_G0028613
protein coding gene Chr4:114098942-114106534 (-)
AKR/J MGP_AKRJ_G0028563
protein coding gene Chr4:116594973-116602565 (-)
BALB/cJ MGP_BALBcJ_G0028634
protein coding gene Chr4:114721076-114728667 (-)
C3H/HeJ MGP_C3HHeJ_G0028348
protein coding gene Chr4:118174971-118182567 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029075
protein coding gene Chr4:123235134-123242726 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026359
protein coding gene Chr4:108124475-108132455 (-)
CAST/EiJ MGP_CASTEiJ_G0027782
protein coding gene Chr4:115383708-115391281 (-)
CBA/J MGP_CBAJ_G0028315
protein coding gene Chr4:126615795-126623426 (-)
DBA/2J MGP_DBA2J_G0028463
protein coding gene Chr4:114717464-114725056 (-)
FVB/NJ MGP_FVBNJ_G0028431
protein coding gene Chr4:113233823-113241416 (-)
LP/J MGP_LPJ_G0028565
protein coding gene Chr4:118844357-118851949 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028458
protein coding gene Chr4:131528688-131536281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029112
protein coding gene Chr4:117739076-117746668 (-)
PWK/PhJ MGP_PWKPhJ_G0027508
protein coding gene Chr4:111533227-111540867 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027331
protein coding gene Chr4:114049138-114056725 (-)
WSB/EiJ MGP_WSBEiJ_G0027861
protein coding gene Chr4:117629524-117637117 (-)



Homology
more
  • Human Ortholog
    DMAP1, DNA methyltransferase 1 associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMAP1, DNA methyltransferase 1 associated protein 1
  • Synonyms
    DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4
  • Links
    NCBI Gene ID: 55929
    neXtProt AC: NX_Q9NPF5
    UniProt: Q9NPF5

  • Chr Location
    1p34.1; chr1:44213455-44220681 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die prior to implantation with no 8-cell embryos detected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66233 NCBI Gene Model | MGI Sequence Detail 7573 C57BL/6J ±  kb
transcript NM_001419061 RefSeq | MGI Sequence Detail 1678 C57BL/6  
polypeptide Q9JI44 UniProt | EBI | MGI Sequence Detail 468 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006533 DNA methyltransferase 1-associated protein 1
  • InterPro Domains
    IPR032563 DAMP1, SANT/Myb-like domain
    IPR008468 DNA methyltransferase 1-associated 1
    IPR027109 SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1
Molecular
Reagents
less
  • All nucleic 71
    cDNA 71

    Microarray probesets 3
References
more
  • Summaries
    All 48
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:81304 Rountree MR, et al., DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet. 2000 Jul;25(3):269-77
  • Latest
    J:294072 Yu JSL, et al., CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors. Stem Cells. 2019 Jul;37(7):958-972

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory