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Serpinb1a
Gene Detail
 Symbol
Name
ID
Serpinb1a
serine (or cysteine) peptidase inhibitor, clade B, member 1a
MGI:1913472
Synonyms 1190005M04Rik, EIA, ELANH2, LEI, MNEI, M/NEI, ovalbumin
Feature Type protein coding gene
Genetic Map
Chromosome 13
13.75 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:32842092-32851185 bp, - strand
From VEGA annotation of GRCm38

  9094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133768  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 3 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpinb1a

Human
homologs
Human Homolog SERPINB1, serpin peptidase inhibitor, clade B (ovalbumin), member 1
NCBI Gene ID 1992
neXtProt AC  NX_P30740
Human Synonyms  EI, ELANH2, HEL57, LEI, MNEI, M/NEI, PI2, PI-2
Human Chr (Location)  6p25; chr6:2832332-2842049 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice fail to clear P. aeruginosa lung infection and show increased mortality associated with late-onset failed bacterial clearance, partly due to elevated neutrophil necrosis, release of neutrophil protease activity, higher cytokine production and proteolysis of surfactant protein-D.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component cytoplasm, extracellular space, ...
Function peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (92)    Tissues (9)    Images (24)
Theiler Stages: 20, 23
Assay TypeResults
RNA in situ 90
RT-PCR 2
cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(86) Genomic(3) cDNA(82) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000000694 (Evidence)
Ensembl Gene ModelENSMUSG00000044734 (Evidence)
Entrez Gene66222 (Evidence)
UniGene20144
DFCITC1575000
DoTSDT.101317665, DT.87072595, DT.94352053
NIA Mouse Gene IndexU034668
Consensus CDS ProjectCCDS26428.1
International Mouse Knockout Project StatusSerpinb1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000694 VEGA Gene Model | MGI Sequence Detail 9094 C57BL/6J ±  kb
transcript OTTMUST00000001326 VEGA | MGI Sequence Detail 1825 Not Applicable 
polypeptide OTTMUSP00000000623 VEGA | MGI Sequence Detail 348 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015557 Protease inhibitor I4, serpin B1
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000015941 leukocyte elastase inhibitor A
References (Earliest) J:19094 Hara T, et al., Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood. 1994 Jul 1;84(1):189-99
(Latest) J:198213 Baumann M, et al., SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G. Blood. 2013 May 9;121(19):3900-7, S1-6
All references(41)
Other
accession IDs
MGI:2145215

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory