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Serpinb1a Gene Detail
Summary
  • Symbol
    Serpinb1a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 1a
  • Synonyms
    1190005M04Rik, EIA, ELANH2, LEI, MNEI, M/NEI, ovalbumin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913472
    NCBI Gene: 66222
  • Gene Overview
    MyGene.info: SERPINB1
Location & Maps
more
  • Sequence Map
    Chr13:32842092-32851185 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9094 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 13.75 cM, cytoband A4
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SERPINB1, serpin family B member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SERPINB1, serpin family B member 1
    Orthology source: HomoloGene
  • Synonyms
    EI, ELANH2, HEL57, HEL-S-27, LEI, MNEI, M/NEI, PI2, PI-2
  • Links
    NCBI Gene ID: 1992
    neXtProt AC: NX_P30740

  • Chr Location
    6p25; chr6:2832332-2842049 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Serpinb1a
  • Incidental Mutations
Homozygous null mice fail to clear P. aeruginosa lung infection and show increased mortality associated with late-onset failed bacterial clearance, partly due to elevated neutrophil necrosis, release of neutrophil protease activity, higher cytokine production and proteolysis of surfactant protein-D.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000694 VEGA Gene Model | MGI Sequence Detail 9094 C57BL/6J ±  kb
transcript OTTMUST00000001326 VEGA | MGI Sequence Detail 1825 Not Applicable  
polypeptide OTTMUSP00000000623 VEGA | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    Genomic 3
    cDNA 82
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2145215
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:19094 Hara T, et al., Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood. 1994 Jul 1;84(1):189-99
  • Latest
    J:217636 Loison F, et al., Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation. J Clin Invest. 2014 Oct;124(10):4445-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory