Homozygous null mice fail to clear P. aeruginosa lung infection and show increased mortality associated with late-onset failed bacterial clearance, partly due to elevated neutrophil necrosis, release of neutrophil protease activity, higher cytokine production and proteolysis of surfactant protein-D.
|Process||negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...|
|Component||cytoplasm, extracellular exosome, ...|
|Function||peptidase inhibitor activity, serine-type endopeptidase inhibitor activity|
|VEGA Gene Model||OTTMUSG00000000694 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000044734 (Evidence)|
|Entrez Gene||66222 (Evidence)|
|DoTS||DT.101317665, DT.87072595, DT.94352053|
|NIA Mouse Gene Index||U034668|
|Consensus CDS Project||CCDS26428.1|
|International Mouse Phenotyping Consortium Status||Serpinb1a|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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