Rgcc MGI Mouse Gene Detail - MGI:1913464

Symbol

Rgcc
Name

regulator of cell cycle
Synonyms

1190002H23Rik, RGC-32

Feature Type

protein coding gene
IDs

MGI:1913464
NCBI Gene: 66214
Gene Overview

MyGene.info: RGCC
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:79288750-79301635 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 42.59 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

197 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913464	protein coding gene	Chr14:79288750-79301645 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021594	protein coding gene	Chr14:74401933-74416469 (-)
A/J	MGP_AJ_G0021552	protein coding gene	Chr14:72556069-72569834 (-)
AKR/J	MGP_AKRJ_G0021529	protein coding gene	Chr14:74715070-74729266 (-)
BALB/cJ	MGP_BALBcJ_G0021559	protein coding gene	Chr14:72402096-72415472 (-)
C3H/HeJ	MGP_C3HHeJ_G0021336	protein coding gene	Chr14:74442654-74457830 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021999	protein coding gene	Chr14:77562971-77575708 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019537	protein coding gene	Chr14:70105785-70118619 (-)
CAST/EiJ	MGP_CASTEiJ_G0020853	protein coding gene	Chr14:71216737-71241759 (-)
CBA/J	MGP_CBAJ_G0021304	protein coding gene	Chr14:80037725-80057774 (-)
DBA/2J	MGP_DBA2J_G0021429	protein coding gene	Chr14:71961963-71974971 (-)
FVB/NJ	MGP_FVBNJ_G0021405	protein coding gene	Chr14:71302141-71314992 (-)
LP/J	MGP_LPJ_G0021497	protein coding gene	Chr14:75497403-75513663 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021432	protein coding gene	Chr14:78699952-78716056 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022022	protein coding gene	Chr14:74025414-74039206 (-)
PWK/PhJ	MGP_PWKPhJ_G0020596	protein coding gene	Chr14:68750743-68764253 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020433	protein coding gene	Chr14:70004516-70019259 (-)
WSB/EiJ	MGP_WSBEiJ_G0020906	protein coding gene	Chr14:74376923-74394071 (-)

Human Ortholog

RGCC, regulator of cell cycle

Vertebrate Orthologs

10

Human Ortholog

RGCC, regulator of cell cycle
Orthology source: HomoloGene, HGNC
Synonyms

bA157L14.2, C13orf15, RGC32, RGC-32
Links

HGNC:20369

NCBI Gene ID: 28984

neXtProt AC: NX_Q9H4X1

UniProt: Q9H4X1
Chr Location

13q14.11; chr13:41457406-41470877 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8544
1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: RGCC
Gene Tree

Rgcc

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Targeted

2
Genomic Mutations

1 involving Rgcc
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit partial prenatal lethality, abnormal vitelline vasculature morphology, and fetal growth restriction due to impaired placental angiogenesis.

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All GO Annotations

51
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

206
Tissues

43
cDNA Data

76
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgcc

ZFIN rgcc

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Rgcc interacts with 49 markers (Mir7-1, Mir10b, Mir18, ...) View All

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS49552.1
UniGene

29811

Ensembl

ENSMUSG00000022018 (Evidence)
NCBI Gene

66214

			Length	Strain/Species	Flank
genomic	66214	NCBI Gene Model \| MGI Sequence Detail	12886	C57BL/6J	± kb
transcript	NM_025427	RefSeq \| MGI Sequence Detail	934	Not Specified
polypeptide	Q9DBX1	UniProt \| EBI \| MGI Sequence Detail	137	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013935 response gene to complement 32 protein

(term hierarchy)
InterPro Domains

IPR029252 Regulator of cell cycle RGCC

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All nucleic 76

cDNA 76

Microarray probesets 4

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:263972 Hu YJ, et al., Renal proteomic analysis of RGC-32 knockout mice reveals the potential mechanism of RGC-32 in regulating cell cycle. Am J Transl Res. 2018;10(3):847-856

TSS for Rgcc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129899	Chr14:79301623-79301641 (-)	3 bp
Tssr129898	Chr14:79301074-79301092 (-)	552 bp
Tssr129897	Chr14:79301052-79301062 (-)	578 bp
Tssr129896	Chr14:79301040-79301043 (-)	593 bp
Tssr129895	Chr14:79301014-79301026 (-)	615 bp
Tssr129894	Chr14:79300991-79300999 (-)	640 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/15/2019 MGI 6.13