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Nenf Gene Detail
Summary
  • Symbol
    Nenf
  • Name
    neuron derived neurotrophic factor
  • Synonyms
    1110060M21Rik, neudesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913458
    NCBI Gene: 66208
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191038984-191050328 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.28 cM, cytoband H6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913458
 protein coding gene Chr1:191038984-191050391 (-)
129S1/SvImJ ENSMUSG00200003573
 protein coding gene Chr1:188817371-188828790 (-)
A/J ENSMUSG00195008075
 protein coding gene Chr1:188397389-188408820 (-)
AKR/J ENSMUSG00220004570
 protein coding gene Chr1:187641239-187652675 (-)
BALB/cJ ENSMUSG00180016747
 protein coding gene Chr1:188462845-188474270 (-)
C3H/HeJ ENSMUSG00175021649
 protein coding gene Chr1:188650823-188662253 (-)
C57BL/6NJ ENSMUSG00215013225
 protein coding gene Chr1:187871780-187883186 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015049
 protein coding gene Chr1:181109773-181120269 (-)
CAST/EiJ ENSTCUG00005001884
 protein coding gene Chr1:186445418-186457136 (-)
CBA/J ENSMUSG00210003370
 protein coding gene Chr1:188312450-188323860 (-)
DBA/2J ENSMUSG00185009995
 protein coding gene Chr1:192925708-192937120 (-)
FVB/NJ ENSMUSG00205003999
 protein coding gene Chr1:187308890-187320315 (-)
JF1/MsJ ENSUMUG00000006277
 protein coding gene Chr1:191918000-191929309 (-)
LP/J ENSMUSG00230021497
 protein coding gene Chr1:192461724-192473148 (-)
NOD/ShiLtJ ENSMUSG00190029055
 protein coding gene Chr1:188295949-188307357 (-)
NZO/HlLtJ ENSMUSG00225016089
 protein coding gene Chr1:196222623-196234033 (-)
PWK/PhJ ENSLUMG00010006060
 protein coding gene Chr1:187144677-187156090 (-)
SPRET/EiJ ENSMSPG00010023140
 protein coding gene Chr1:190688939-190699979 (-)
WSB/EiJ ENSIUOG00005004385
 protein coding gene Chr1:187646138-187657548 (-)



Homology
more
  • Human Ortholog
    NENF, neudesin neurotrophic factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NENF, neudesin neurotrophic factor
  • Synonyms
    CIR2, SCIRP10, SPUF
  • Links
    NCBI Gene ID: 29937
    UniProt: Q9UMX5

  • Chr Location
    1q32.3; chr1:212432853-212446379 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased anxiety-related response, abnormal dendrite morphology and decreased dopamine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    29
  • cDNA Data
    29
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66208 NCBI Gene Model | MGI Sequence Detail 11345 C57BL/6J ±  kb
transcript NM_025424 RefSeq | MGI Sequence Detail 681 C57BL/6  
polypeptide Q9CQ45 UniProt | EBI | MGI Sequence Detail 171 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 29
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:282679 Moutaoufik MT, et al., Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. iScience. 2019 Sep 27;19:1114-1132
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory