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Cks2
Gene Detail
Symbol

Name
ID
Cks2
CDC28 protein kinase regulatory subunit 2
MGI:1913447
Synonyms
1110038L14Rik, CKSHS2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
26.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:51645232-51650660 bp, + strand
From VEGA annotation of GRCm38

  5429 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CKS2
Protein SuperFamily: cell division control protein
Gene Tree: Cks2

Human
homologs
CKS2, CDC28 protein kinase regulatory subunit 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1164
neXtProt AC: NX_P33552

Human Synonyms: CKSHS2

Human Chr (Location): 9q22; chr9:89311195-89316703 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(51) Targeted(3) Transgenic(1)
 
Mice homozygous for a knock-out allele are viable but sterile in both sexes due to failure of both male and female germ cells to progress beyond the first meiotic metaphase.
 
Interactions
Cks2 interacts with 110 markers (Mir7-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process cell cycle, cell division, ...
Function cyclin-dependent protein serine/threonine kinase regulator activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (10)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 7
cDNA source data(93)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cks2 ; ZFIN cks2    NEW 
Molecular
reagents
All nucleic(95) cDNA(93) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000023833 (Evidence)
Ensembl Gene Model ENSMUSG00000062248 (Evidence)
Entrez Gene 66197 (Evidence)
UniGene 222228
DFCI TC1635028, TC1576397
DoTS DT.495541, DT.94184595
NIA Mouse Gene Index U014843, U108226, U165376, U109039
Consensus CDS Project CCDS36664.1
International Mouse Phenotyping Consortium Status Cks2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023833 VEGA Gene Model | MGI Sequence Detail 5429 C57BL/6J ±  kb
transcript OTTMUST00000058218 VEGA | MGI Sequence Detail 692 Not Applicable 
polypeptide OTTMUSP00000028176 VEGA | MGI Sequence Detail 79 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000789 Cyclin-dependent kinase, regulatory subunit
Protein Ontology PR:000005519 cyclin-dependent kinases regulatory subunit 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory