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Cks2 Gene Detail
Summary
  • Symbol
    Cks2
  • Name
    CDC28 protein kinase regulatory subunit 2
  • Synonyms
    1110038L14Rik, CKSHS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913447
    NCBI Gene: 66197
  • Gene Overview
    MyGene.info: CKS2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51645232-51650660 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913447
protein coding gene Chr13:51645232-51650662 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020551
protein coding gene Chr13:50866260-50873720 (+)
A/J MGP_AJ_G0020505
protein coding gene Chr13:49064461-49069889 (+)
AKR/J MGP_AKRJ_G0020483
protein coding gene Chr13:50457166-50464260 (+)
BALB/cJ MGP_BALBcJ_G0020501
protein coding gene Chr13:49252839-49258267 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0020935
protein coding gene Chr13:52435738-52441059 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018517
protein coding gene Chr13:46862212-46867613 (+)
CAST/EiJ MGP_CASTEiJ_G0019814
protein coding gene Chr13:50258599-50265702 (+)
CBA/J MGP_CBAJ_G0020260
protein coding gene Chr13:54467384-54472833 (+)
DBA/2J MGP_DBA2J_G0020383
protein coding gene Chr13:48631125-48637381 (+)
FVB/NJ MGP_FVBNJ_G0020362
protein coding gene Chr13:48059957-48065502 (+)
LP/J MGP_LPJ_G0020459
protein coding gene Chr13:51136981-51144063 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020391
protein coding gene Chr13:54062294-54070978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020978
protein coding gene Chr13:50029845-50037470 (+)
PWK/PhJ MGP_PWKPhJ_G0019571
protein coding gene Chr13:48552318-48558020 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019398
protein coding gene Chr13:48918028-48924382 (+)
WSB/EiJ MGP_WSBEiJ_G0019876
protein coding gene Chr13:50340553-50345968 (+)



Homology
more
  • Human Ortholog
    CKS2, CDC28 protein kinase regulatory subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CKS2, CDC28 protein kinase regulatory subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CKSHS2
  • Links
    NCBI Gene ID: 1164
    neXtProt AC: NX_P33552
    UniProt: P33552

  • Chr Location
    9q22.2; chr9:89311195-89316703 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable but sterile in both sexes due to failure of both male and female germ cells to progress beyond the first meiotic metaphase.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062248 Ensembl Gene Model | MGI Sequence Detail 5429 C57BL/6J ±  kb
    transcript ENSMUST00000075853 Ensembl | MGI Sequence Detail 692 Not Applicable  
    polypeptide ENSMUSP00000075250 Ensembl | MGI Sequence Detail 79 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005519 cyclin-dependent kinases regulatory subunit 2
    • InterPro Domains
      IPR000789 Cyclin-dependent kinase, regulatory subunit
      IPR036858 Cyclin-dependent kinase, regulatory subunit superfamily
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 94
      Primer pair 2

      Microarray probesets 7
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:217915 Flowers S, et al., p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation. Bone. 2014 Dec;69:47-54

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory