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Cks2
Gene Detail
Symbol

Name
ID
Cks2
CDC28 protein kinase regulatory subunit 2
MGI:1913447
Synonyms
1110038L14Rik, CKSHS2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
26.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:51645232-51650660 bp, + strand
From VEGA annotation of GRCm38

  5429 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86883  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cell division control protein
Gene Tree: Cks2

Human
homologs
Human Homolog CKS2, CDC28 protein kinase regulatory subunit 2
NCBI Gene ID 1164
neXtProt AC  NX_P33552
Human Synonyms  CKSHS2
Human Chr (Location)  9q22; chr9:89311198-89316703 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(51) Targeted(3) Transgenic(1)
 
Mice homozygous for a knock-out allele are viable but sterile in both sexes due to failure of both male and female germ cells to progress beyond the first meiotic metaphase.
 
Interactions
Cks2 interacts with 110 markers (Mir7-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell cycle, cell division, ...
Function cyclin-dependent protein serine/threonine kinase regulator activity, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (10)    Tissues (7)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
RT-PCR 7
cDNA source data(93)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(93) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023833 (Evidence)
Ensembl Gene ModelENSMUSG00000062248 (Evidence)
Entrez Gene66197 (Evidence)
UniGene222228
DFCITC1576397, TC1635028
DoTSDT.495541, DT.94184595
NIA Mouse Gene IndexU014843, U108226, U109039, U165376
Consensus CDS ProjectCCDS36664.1
International Mouse Knockout Project StatusCks2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023833 VEGA Gene Model | MGI Sequence Detail 5429 C57BL/6J ±  kb
transcript OTTMUST00000058218 VEGA | MGI Sequence Detail 692 Not Applicable 
polypeptide OTTMUSP00000028176 VEGA | MGI Sequence Detail 79 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000789 Cyclin-dependent kinase, regulatory subunit
Protein Ontology PR:000005519 cyclin-dependent kinases regulatory subunit 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory