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Cks2 Gene Detail
Summary
  • Symbol
    Cks2
  • Name
    CDC28 protein kinase regulatory subunit 2
  • Synonyms
    1110038L14Rik, CKSHS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913447
    NCBI Gene: 66197
  • Gene Overview
    MyGene.info: CKS2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:51645232-51650660 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5429 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.12 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CKS2, CDC28 protein kinase regulatory subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CKS2, CDC28 protein kinase regulatory subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CKSHS2
  • Links
    NCBI Gene ID: 1164
    neXtProt AC: NX_P33552
    UniProt: P33552

  • Chr Location
    9q22.2; chr9:89311195-89316703 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable but sterile in both sexes due to failure of both male and female germ cells to progress beyond the first meiotic metaphase.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023833 VEGA Gene Model | MGI Sequence Detail 5429 C57BL/6J ±  kb
    transcript OTTMUST00000058218 VEGA | MGI Sequence Detail 692 Not Applicable  
    polypeptide OTTMUSP00000028176 VEGA | MGI Sequence Detail 79 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      40 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005519 cyclin-dependent kinases regulatory subunit 2
    • InterPro Domains
      IPR000789 Cyclin-dependent kinase, regulatory subunit
      IPR036858 Cyclin-dependent kinase, regulatory subunit superfamily
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 93
      Primer pair 2

      Microarray probesets 7
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:217915 Flowers S, et al., p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation. Bone. 2014 Dec;69:47-54

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory