Pycr3 MGI Mouse Gene Detail - MGI:1913444 - pyrroline-5-carboxylate reductase 3

Symbol

Pycr3
Name

pyrroline-5-carboxylate reductase 3
Synonyms

1110058B13Rik, 2700073G24Rik, Pycrl

Feature Type

protein coding gene
IDs

MGI:1913444
NCBI Gene: 66194
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:75788319-75793369 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.09 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

43 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913444	protein coding gene	Chr15:75788319-75793409 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021965	protein coding gene	Chr15:75965848-75971028 (-)
A/J	MGP_AJ_G0021923	protein coding gene	Chr15:73198386-73203493 (-)
AKR/J	MGP_AKRJ_G0021906	protein coding gene	Chr15:75177220-75182395 (-)
BALB/cJ	MGP_BALBcJ_G0021932	protein coding gene	Chr15:73219741-73224843 (-)
C3H/HeJ	MGP_C3HHeJ_G0021704	protein coding gene	Chr15:75238232-75243422 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022372	protein coding gene	Chr15:78802525-78807632 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019903	protein coding gene	Chr15:69871370-69876464 (-)
CAST/EiJ	MGP_CASTEiJ_G0021223	protein coding gene	Chr15:76021311-76026388 (-)
CBA/J	MGP_CBAJ_G0021671	protein coding gene	Chr15:81317010-81322180 (-)
DBA/2J	MGP_DBA2J_G0021796	protein coding gene	Chr15:72729441-72734626 (-)
FVB/NJ	MGP_FVBNJ_G0021777	protein coding gene	Chr15:71780122-71785209 (-)
LP/J	MGP_LPJ_G0021867	protein coding gene	Chr15:76047387-76052484 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021801	protein coding gene	Chr15:86620497-86625660 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022392	protein coding gene	Chr15:75421815-75426907 (-)
PWK/PhJ	MGP_PWKPhJ_G0020964	protein coding gene	Chr15:72866267-72871360 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020803	protein coding gene	Chr15:75151775-75156802 (-)
WSB/EiJ	MGP_WSBEiJ_G0021275	protein coding gene	Chr15:75509117-75514202 (-)

Human Ortholog

PYCR3, pyrroline-5-carboxylate reductase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PYCR3, pyrroline-5-carboxylate reductase 3
Synonyms

PYCRL
Links

HGNC:25846

NCBI Gene ID: 65263

neXtProt AC: NX_Q53H96

UniProt: Q53H96
Chr Location

8q24.3; chr8:143603210-143609773 (-) GRCh38

MGI Vertebrate Homology

Pycr3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PYCR3
Protein SuperFamily

Pyrrol-5-carb_rd
Gene Tree

Pycr3

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References

1 with disease annotations

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Phenotype Summary

31 phenotype references

All Mutations and Alleles

14
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

2
Targeted

2
Genomic Mutations

5 involving Pycr3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

83
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pycr3

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All Sequences

40
RefSeq

4
UniProt

1
CCDS

CCDS37109.1

Ensembl

ENSMUSG00000022571 (Evidence)
NCBI Gene

66194

			Length	Strain/Species	Flank
genomic	66194	NCBI Gene Model \| MGI Sequence Detail	5051	C57BL/6J	± kb
transcript	NM_025412	RefSeq \| MGI Sequence Detail	1302	C57BL/6
polypeptide	Q9DCC4	UniProt \| EBI \| MGI Sequence Detail	274	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013517 pyrroline-5-carboxylate reductase 3

(term hierarchy)
EC

1.5.1.2
InterPro Domains

IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily

IPR036291 NAD(P)-binding domain superfamily

IPR000304 Pyrroline-5-carboxylate reductase

IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain

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All nucleic 83

cDNA 83

Microarray probesets 3

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MGI:1914445

Summaries

All 59

Developmental Gene Expression 1

Diseases 1

Gene Ontology 7

Phenotypes 31
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Pycr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134886	Chr15:75793312-75793382 (-)	22 bp
Tssr134885	Chr15:75793075-75793123 (-)	270 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23