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Acer3 Gene Detail
Summary
  • Symbol
    Acer3
  • Name
    alkaline ceramidase 3
  • Synonyms
    1110057L18Rik, 5430429L08Rik, Phca
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913440
    NCBI Gene: 66190
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97863015-97970415 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2221 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913440
 protein coding gene Chr7:97855596-97970415 (-)
129S1/SvImJ ENSMUSG00200048898
 protein coding gene Chr7:84680230-84788633 (-)
A/J ENSMUSG00195036818
 protein coding gene Chr7:89185170-89293596 (-)
AKR/J ENSMUSG00220047552
 protein coding gene Chr7:82602490-82710921 (-)
BALB/cJ ENSMUSG00180026489
 protein coding gene Chr7:85858591-85967007 (-)
C3H/HeJ ENSMUSG00175022474
 protein coding gene Chr7:86506957-86615179 (-)
C57BL/6NJ ENSMUSG00215033023
 protein coding gene Chr7:85698484-85813303 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030015
 protein coding gene Chr7:100899371-100980094 (-)
CAST/EiJ ENSTCUG00005030528
 protein coding gene Chr7:89086490-89197358 (-)
CBA/J ENSMUSG00210025311
 protein coding gene Chr7:86354871-86463113 (-)
DBA/2J ENSMUSG00185029797
 protein coding gene Chr7:90681652-90789876 (-)
FVB/NJ ENSMUSG00205021917
 protein coding gene Chr7:86356949-86465366 (-)
JF1/MsJ ENSUMUG00000028784
 protein coding gene Chr7:95580261-95688560 (-)
LP/J ENSMUSG00230038243
 protein coding gene Chr7:96797225-96905631 (-)
NOD/ShiLtJ ENSMUSG00190017444
 protein coding gene Chr7:86631782-86740194 (-)
NZO/HlLtJ ENSMUSG00225048486
 protein coding gene Chr7:94983665-95092071 (-)
PWK/PhJ ENSLUMG00010046455
 protein coding gene Chr7:84810850-84919012 (-)
SPRET/EiJ ENSMSPG00010010289
 protein coding gene Chr7:86050818-86148952 (-)
WSB/EiJ ENSIUOG00005009736
 protein coding gene Chr7:86967387-87081095 (-)



Homology
more
  • Human Ortholog
    ACER3, alkaline ceramidase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACER3, alkaline ceramidase 3
  • Synonyms
    APHC, PHCA, PLDECO
  • Links
    NCBI Gene ID: 55331
    UniProt: Q9NUN7

  • Chr Location
    11q13.5; chr11:76860859-77026797 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered homeostasis of ceramides and their sphingolipid derivatives in the aging brain resulting in Purkinje cell degeneration, decreased vertical activity, limb grasping, and impaired motor coordination and balance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    701
  • Tissues
    98
  • cDNA Data
    22
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66190 NCBI Gene Model | MGI Sequence Detail 107401 C57BL/6J ±  kb
transcript NM_001360617 RefSeq | MGI Sequence Detail 4087 C57BL/6  
polypeptide Q9D099 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918651, MGI:2142169
References
more
  • Summaries
    All 56
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 21
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory