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Acer3 Gene Detail
Summary
  • Symbol
    Acer3
  • Name
    alkaline ceramidase 3
  • Synonyms
    1110057L18Rik, 5430429L08Rik, Phca
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913440
    NCBI Gene: 66190
  • Gene Overview
    MyGene.info: ACER3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:98213660-98309548 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    624 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913440
protein coding gene Chr7:98206389-98321208 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032537
protein coding gene Chr7:100943661-101027699 (-)
A/J MGP_AJ_G0032511
protein coding gene Chr7:98449680-98537175 (-)
AKR/J MGP_AKRJ_G0032447
protein coding gene Chr7:100790482-100879340 (-)
BALB/cJ MGP_BALBcJ_G0032522
protein coding gene Chr7:98138507-98227782 (-)
C3H/HeJ MGP_C3HHeJ_G0032237
protein coding gene Chr7:101145945-101234091 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033020
protein coding gene Chr7:104858278-104951930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030015
protein coding gene Chr7:100899371-100980094 (-)
CAST/EiJ MGP_CASTEiJ_G0031564
protein coding gene Chr7:92662097-92752708 (-)
CBA/J MGP_CBAJ_G0032204
protein coding gene Chr7:108415453-108523229 (-)
DBA/2J MGP_DBA2J_G0032356
protein coding gene Chr7:96785084-96867588 (-)
FVB/NJ MGP_FVBNJ_G0032312
protein coding gene Chr7:96589171-96672244 (-)
LP/J MGP_LPJ_G0032445
protein coding gene Chr7:102267551-102357245 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032345
protein coding gene Chr7:109953078-110058792 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033042
protein coding gene Chr7:100065044-100150096 (-)
PWK/PhJ MGP_PWKPhJ_G0031282
protein coding gene Chr7:89861615-89954678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031125
protein coding gene Chr7:87322263-87422683 (-)
WSB/EiJ MGP_WSBEiJ_G0031681
protein coding gene Chr7:100714433-100810215 (-)



Homology
more
  • Human Ortholog
    ACER3, alkaline ceramidase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACER3, alkaline ceramidase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APHC, PHCA, PLDECO
  • Links
    NCBI Gene ID: 55331
    neXtProt AC: NX_Q9NUN7
    UniProt: Q9NUN7

  • Chr Location
    11q13.5; chr11:76860873-77026797 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5410
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACER3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered homeostasis of ceramides and their sphingolipid derivatives in the aging brain resulting in Purkinje cell degeneration, decreased vertical activity, limb grasping, and impaired motor coordination and balance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66190 NCBI Gene Model | MGI Sequence Detail 95889 C57BL/6J ±  kb
transcript NM_001360617 RefSeq | MGI Sequence Detail 4087 C57BL/6  
polypeptide Q9D099 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918651, MGI:2142169
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:256650 Li F, et al., Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 Jun;32(6):3058-3069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory