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Pgls Gene Detail
Summary
  • Symbol
    Pgls
  • Name
    6-phosphogluconolactonase
  • Synonyms
    1110030K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913421
    NCBI Gene: 66171
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71592184-71596267 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913421
protein coding gene Chr8:71592176-71601092 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033756
protein coding gene Chr8:72004460-72014815 (+)
A/J MGP_AJ_G0033739
protein coding gene Chr8:69066810-69075725 (+)
AKR/J MGP_AKRJ_G0033665
protein coding gene Chr8:71102163-71111537 (+)
BALB/cJ MGP_BALBcJ_G0033735
protein coding gene Chr8:69238500-69249613 (+)
C3H/HeJ MGP_C3HHeJ_G0033445
protein coding gene Chr8:71686086-71697455 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034253
protein coding gene Chr8:74743221-74752129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031195
protein coding gene Chr8:63702486-63711218 (+)
CAST/EiJ MGP_CASTEiJ_G0032770
protein coding gene Chr8:71146790-71155687 (+)
CBA/J MGP_CBAJ_G0033423
protein coding gene Chr8:77391946-77402431 (+)
DBA/2J MGP_DBA2J_G0033577
protein coding gene Chr8:68795333-68804675 (+)
FVB/NJ MGP_FVBNJ_G0033519
protein coding gene Chr8:67880841-67892392 (+)
LP/J MGP_LPJ_G0033664
protein coding gene Chr8:71975703-71987148 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033566
protein coding gene Chr8:79935720-79944635 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034270
protein coding gene Chr8:71170381-71182715 (+)
PWK/PhJ MGP_PWKPhJ_G0032477
protein coding gene Chr8:68079744-68088744 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032314
protein coding gene Chr8:70116862-70125838 (+)
WSB/EiJ MGP_WSBEiJ_G0032886
protein coding gene Chr8:71517017-71527472 (+)



Homology
more
  • Human Ortholog
    PGLS, 6-phosphogluconolactonase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PGLS, 6-phosphogluconolactonase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    6PGL, HEL-S-304
  • Links
    NCBI Gene ID: 25796
    neXtProt AC: NX_O95336
    UniProt: O95336

  • Chr Location
    19p13.11; chr19:17511623-17521291 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6037
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PGLS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Pgls
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66171 NCBI Gene Model | MGI Sequence Detail 4084 C57BL/6J ±  kb
transcript NM_001294269 RefSeq | MGI Sequence Detail 1167 C57BL/6  
polypeptide Q9CQ60 UniProt | EBI | MGI Sequence Detail 257 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142542
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory