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Tmem14c Gene Detail
Summary
  • Symbol
    Tmem14c
  • Name
    transmembrane protein 14C
  • Synonyms
    1110021D01Rik, HSPC194
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913404
    NCBI Gene: 66154
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:41016292-41022586 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6295 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 20.25 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TMEM14C, transmembrane protein 14C
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TMEM14C, transmembrane protein 14C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA421M1.6, C6orf53, HSPC194, MSTP073, NET26
  • Links
    NCBI Gene ID: 51522
    neXtProt AC: NX_Q9P0S9
    UniProt: Q9P0S9

  • Chr Location
    6p24.2; chr6:10722915-10731129 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit porphyrin accumulation in fetal liver, erythroid maturation arrest, and embryonic lethality due to severe anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021361 Ensembl Gene Model | MGI Sequence Detail 6295 C57BL/6J ±  kb
    transcript ENSMUST00000021790 Ensembl | MGI Sequence Detail 914 Not Applicable  
    polypeptide ENSMUSP00000021790 Ensembl | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      29 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      cDNA 172

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145355
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:212530 Yien YY, et al., TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest. 2014 Aug 26;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory