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Dnajc15 Gene Detail
Summary
  • Symbol
    Dnajc15
  • Name
    DnaJ heat shock protein family (Hsp40) member C15
  • Synonyms
    1110003P16Rik, Dnajd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913398
    NCBI Gene: 66148
Location & Maps
more
  • Sequence Map
    Chr14:77826217-77874917 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48701 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 41.04 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNAJC15, DnaJ heat shock protein family (Hsp40) member C15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAJC15, DnaJ heat shock protein family (Hsp40) member C15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DNAJD1, HSD18, MCJ
  • Links
    NCBI Gene ID: 29103
    neXtProt AC: NX_Q9Y5T4

  • Chr Location
    13q14.1; chr13:43023226-43109170 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Targeted
    3
  • Genomic Mutations
    1 involving Dnajc15
Mice homozygous for a knock-out allele exhibit increased mitochondrial activity that results in rapid metabolism in fasted mice or mice fed a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66148 NCBI Gene Model | MGI Sequence Detail 48701 C57BL/6J ±  kb
transcript NM_025384 RefSeq | MGI Sequence Detail 671 C57BL/6  
polypeptide Q78YY6 UniProt | EBI | MGI Sequence Detail 149 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    366 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000029418 DnaJ homolog subfamily C member 15
  • InterPro Domains
    IPR001623 DnaJ domain
Molecular
Reagents
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  • All nucleic 80
    cDNA 80

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:204025 Hatle KM, et al., MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol Cell Biol. 2013 Jun;33(11):2302-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory