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Eef1e1
Gene Detail
Symbol

Name
ID
Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
MGI:1913393
Synonyms
1110003A02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
18.38 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:38645698-38659028 bp, - strand
From Ensembl annotation of GRCm38

  13331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3161  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EEF1E1
Gene Tree: Eef1e1

Human
homologs
EEF1E1, eukaryotic translation elongation factor 1 epsilon 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9521
neXtProt AC: NX_O43324

Human Synonyms: AIMP3, P18

Human Chr (Location): 6p24.3; chr6:8073360-8102595 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(17)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele display early embryonic lethality while heterozygous mice exhibit prenatal semi-lethality and a significantly increased incidence of spontaneous tumorigenesis after 15 months of age.
 
Interactions
Eef1e1 interacts with 76 markers (Mir7-1, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process DNA repair, embryo development, ...
Component aminoacyl-tRNA synthetase multienzyme complex, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (42)    Tissues (29)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(44)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eef1e1 ; ZFIN eef1e1    NEW 
Molecular
reagents
All nucleic(44) cDNA(44)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000001707 (Evidence)
Entrez Gene 66143 (Evidence)
UniGene 490319
DFCI TC1578294
DoTS DT.492229, DT.91587252, DT.110968228
NIA Mouse Gene Index U034701
Consensus CDS Project CCDS26465.1
International Mouse Phenotyping Consortium Status Eef1e1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001707 Ensembl Gene Model | MGI Sequence Detail 13331 C57BL/6J ±  kb
transcript ENSMUST00000001757 Ensembl | MGI Sequence Detail 1032 Not Applicable 
polypeptide ENSMUSP00000001757 Ensembl | MGI Sequence Detail 174 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000006907 eukaryotic translation elongation factor 1 epsilon-1
References
(Earliest) J:113818 Quevillon S, et al., The p18 component of the multisynthetase complex shares a protein motif with the beta and gamma subunits of eukaryotic elongation factor 1. FEBS Lett. 1996 Oct 14;395(1):63-7
(Latest) J:217053 Oh YS, et al., Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. Aging Cell. 2010 Oct;9(5):810-22
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory