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Eef1e1 Gene Detail
Summary
  • Symbol
    Eef1e1
  • Name
    eukaryotic translation elongation factor 1 epsilon 1
  • Synonyms
    1110003A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913393
    NCBI Gene: 66143
  • Gene Overview
    MyGene.info: EEF1E1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:38645691-38659028 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 18.38 cM, cytoband A5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913393
protein coding gene Chr13:38644207-38659058 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020475
protein coding gene Chr13:37010961-37025536 (-)
A/J MGP_AJ_G0020429
protein coding gene Chr13:35824460-35837616 (-)
AKR/J MGP_AKRJ_G0020407
protein coding gene Chr13:36777787-36790874 (-)
BALB/cJ MGP_BALBcJ_G0020425
protein coding gene Chr13:35926206-35939362 (-)
C3H/HeJ MGP_C3HHeJ_G0020224
protein coding gene Chr13:36611068-36624206 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020858
protein coding gene Chr13:38217754-38230862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018445
protein coding gene Chr13:34010167-34021039 (-)
CAST/EiJ MGP_CASTEiJ_G0019739
protein coding gene Chr13:36392171-36402824 (-)
CBA/J MGP_CBAJ_G0020185
protein coding gene Chr13:39837569-39850726 (-)
DBA/2J MGP_DBA2J_G0020307
protein coding gene Chr13:35343498-35356661 (-)
FVB/NJ MGP_FVBNJ_G0020286
protein coding gene Chr13:34873043-34886171 (-)
LP/J MGP_LPJ_G0020382
protein coding gene Chr13:37253843-37266974 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0020901
protein coding gene Chr13:36341254-36354402 (-)
PWK/PhJ MGP_PWKPhJ_G0019494
protein coding gene Chr13:35471756-35484974 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019801
protein coding gene Chr13:36702102-36715241 (-)



Homology
more
  • Human Ortholog
    EEF1E1, eukaryotic translation elongation factor 1 epsilon 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EEF1E1, eukaryotic translation elongation factor 1 epsilon 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIMP3, P18
  • Links
    NCBI Gene ID: 9521
    neXtProt AC: NX_O43324
    UniProt: O43324

  • Chr Location
    6p24.3; chr6:8073360-8102595 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3161
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EEF1E1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display early embryonic lethality while heterozygous mice exhibit prenatal semi-lethality and a significantly increased incidence of spontaneous tumorigenesis after 15 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66143 NCBI Gene Model | MGI Sequence Detail 13338 C57BL/6J ±  kb
transcript NM_025380 RefSeq | MGI Sequence Detail 1039 C57BL/6  
polypeptide Q9D1M4 UniProt | EBI | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006907 eukaryotic translation elongation factor 1 epsilon-1
  • InterPro Domains
    IPR004046 Glutathione S-transferase, C-terminal
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
Molecular
Reagents
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  • All nucleic 45
    cDNA 45

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:217053 Oh YS, et al., Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. Aging Cell. 2010 Oct;9(5):810-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory