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Cox7b Gene Detail
Summary
  • Symbol
    Cox7b
  • Name
    cytochrome c oxidase subunit 7B
  • Synonyms
    1110004F07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913392
    NCBI Gene: 66142
  • Gene Overview
    MyGene.info: COX7B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:106015700-106022450 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 47.36 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913392
protein coding gene ChrX:106015700-106022450 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036001
protein coding gene ChrX:102798756-102808847 (+)
A/J MGP_AJ_G0035980
protein coding gene ChrX:102567397-102574060 (+)
AKR/J MGP_AKRJ_G0035899
protein coding gene ChrX:105858563-105865221 (+)
BALB/cJ MGP_BALBcJ_G0035970
protein coding gene ChrX:101410138-101417060 (+)
C3H/HeJ MGP_C3HHeJ_G0035677
protein coding gene ChrX:103236011-103242704 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036497
protein coding gene ChrX:105732556-105739238 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033325
protein coding gene ChrX:100040458-100047183 (+)
CAST/EiJ MGP_CASTEiJ_G0034964
protein coding gene ChrX:87382992-87389521 (+)
CBA/J MGP_CBAJ_G0035652
protein coding gene ChrX:109052719-109061253 (+)
DBA/2J MGP_DBA2J_G0035806
protein coding gene ChrX:101860027-101866860 (+)
FVB/NJ MGP_FVBNJ_G0035747
protein coding gene ChrX:101173690-101180345 (+)
LP/J MGP_LPJ_G0035899
protein coding gene ChrX:103753562-103760254 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035779
protein coding gene ChrX:113736865-113746038 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036523
protein coding gene ChrX:102434277-102440997 (+)
PWK/PhJ MGP_PWKPhJ_G0034660
protein coding gene ChrX:84911633-84918511 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034489
protein coding gene ChrX:88117604-88124018 (+)
WSB/EiJ MGP_WSBEiJ_G0035102
protein coding gene ChrX:101136731-101143432 (+)



Homology
more
  • Human Ortholog
    COX7B, cytochrome c oxidase subunit 7B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    COX7B, cytochrome c oxidase subunit 7B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APLCC, LSDMCA2
  • Links
    NCBI Gene ID: 1349
    neXtProt AC: NX_P24311
    UniProt: P24311

  • Chr Location
    Xq21.1; chrX:77899464-77905384 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human COX7B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele appear normal at E6.5. However, no embryos fully derived from mutant ES cells can be generated.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66142 NCBI Gene Model | MGI Sequence Detail 6751 C57BL/6J ±  kb
transcript NM_025379 RefSeq | MGI Sequence Detail 1176 Not Specified  
polypeptide P56393 UniProt | EBI | MGI Sequence Detail 80 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005789 cytochrome c oxidase subunit 7B, mitochondrial
  • InterPro Domains
    IPR008433 Cytochrome C oxidase, subunit VIIB
    IPR023272 Cytochrome C oxidase, subunit VIIB domain superfamily
Molecular
Reagents
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  • All nucleic 226
    cDNA 225
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2138693
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory