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Fkbp11 Gene Detail
Summary
  • Symbol
    Fkbp11
  • Name
    FK506 binding protein 11
  • Synonyms
    1110002O23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913370
    NCBI Gene: 66120
Location & Maps
more
  • Sequence Map
    Chr15:98724373-98728198 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      3826 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 54.65 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FKBP11, FK506 binding protein 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FKBP11, FK506 binding protein 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKBP19
  • Links
    NCBI Gene ID: 51303
    neXtProt AC: NX_Q9NYL4

  • Chr Location
    12q13.12; chr12:48921959-48925547 (-)  GRCh38.p2
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    2
  • Targeted
    1
  • Transgenic
    2
  • Genomic Mutations
    3 involving Fkbp11
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for disruptions of this gene display increased antibody response to antibody challenge and increased inflammatory responses. Measurements of bone density are also increased.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    141
  • Tissues
    17
  • cDNA Data
    51
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003355 Ensembl Gene Model | MGI Sequence Detail 3826 C57BL/6J ±  kb
transcript ENSMUST00000003445 Ensembl | MGI Sequence Detail 731 Not Applicable  
polypeptide ENSMUSP00000003445 Ensembl | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    50 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007533 peptidyl-prolyl cis-trans isomerase FKBP11
  • EC
    5.2.1.8
  • InterPro Domains
    IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
    IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
Molecular
Reagents
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  • All nucleic 51
    cDNA 51

    Microarray probesets 6
References
more
  • Summaries
    All 27
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory