Fkbp11 MGI Mouse Gene Detail - MGI:1913370

Symbol

Fkbp11
Name

FK506 binding protein 11
Synonyms

1110002O23Rik

Feature Type

protein coding gene
IDs

MGI:1913370
NCBI Gene: 66120
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:98622249-98626079 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 54.65 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

37 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913370	protein coding gene	Chr15:98622247-98626079 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022308	protein coding gene	Chr15:100474566-100480541 (-)
A/J	MGP_AJ_G0022266	protein coding gene	Chr15:96512035-96516283 (-)
AKR/J	MGP_AKRJ_G0022241	protein coding gene	Chr15:99483568-99489009 (-)
BALB/cJ	MGP_BALBcJ_G0022273	protein coding gene	Chr15:96705347-96709172 (-)
C3H/HeJ	MGP_C3HHeJ_G0022041	protein coding gene	Chr15:99530996-99536053 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022718	protein coding gene	Chr15:104198871-104202767 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020243	protein coding gene	Chr15:92426851-92430928 (-)
CAST/EiJ	MGP_CASTEiJ_G0021564	protein coding gene	Chr15:100376293-100380119 (-)
CBA/J	MGP_CBAJ_G0022010	protein coding gene	Chr15:107738693-107742901 (-)
DBA/2J	MGP_DBA2J_G0022136	protein coding gene	Chr15:95954354-95958608 (-)
FVB/NJ	MGP_FVBNJ_G0022116	protein coding gene	Chr15:94932572-94936963 (-)
LP/J	MGP_LPJ_G0022208	protein coding gene	Chr15:100627135-100631714 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022136	protein coding gene	Chr15:111754914-111758739 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022733	protein coding gene	Chr15:99564617-99568491 (-)
PWK/PhJ	MGP_PWKPhJ_G0021305	protein coding gene	Chr15:96073164-96077438 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021140	protein coding gene	Chr15:99409119-99413282 (-)
WSB/EiJ	MGP_WSBEiJ_G0021614	protein coding gene	Chr15:100108845-100113090 (-)

Human Ortholog

FKBP11, FKBP prolyl isomerase 11

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FKBP11, FKBP prolyl isomerase 11
Synonyms

FKBP19
Links

HGNC:18624

NCBI Gene ID: 51303

neXtProt AC: NX_Q9NYL4

UniProt: Q9NYL4
Chr Location

12q13.12; chr12:48921959-48925547 (-) GRCh38.p7

Alliance of Genome Resources

Fkbp11 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: FKBP11
Gene Tree

Fkbp11

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

11
Radiation induced

2
Targeted

1
Transgenic

2
Genomic Mutations

3 involving Fkbp11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions of this gene display increased antibody response to antibody challenge and increased inflammatory responses. Measurements of bone density are also increased.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

17
cDNA Data

53
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fkbp11

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All Sequences

39
RefSeq

4
UniProt

1
CCDS

CCDS27803.1

Ensembl

ENSMUSG00000003355 (Evidence)
NCBI Gene

66120

			Length	Strain/Species	Flank
genomic	66120	NCBI Gene Model \| MGI Sequence Detail	3831	C57BL/6J	± kb
transcript	NM_024169	RefSeq \| MGI Sequence Detail	736	C57BL/6
polypeptide	Q9D1M7	UniProt \| EBI \| MGI Sequence Detail	201	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007533 peptidyl-prolyl cis-trans isomerase FKBP11

(term hierarchy)
EC

5.2.1.8
InterPro Domains

IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain

IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily

IPR044609 Peptidyl-prolyl cis-trans isomerase FKBP2/11

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All nucleic 53

cDNA 53

Microarray probesets 6

Summaries

All 53

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:327249 Herrema H, et al., FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity. Cell Metab. 2022 Jul 5;34(7):1004-1022.e8

TSS for Fkbp11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136271	Chr15:98626001-98626068 (-)	44 bp
Tssr136270	Chr15:98625987-98625998 (-)	86 bp
Tssr136269	Chr15:98625909-98625914 (-)	167 bp
Tssr136268	Chr15:98625436-98625490 (-)	616 bp
Tssr136267	Chr15:98625411-98625432 (-)	657 bp
Tssr136266	Chr15:98625377-98625408 (-)	686 bp
Tssr136265	Chr15:98625320-98625324 (-)	757 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/22/2022 MGI 6.21