Fkbp11 Gene Detail

Summary

• Symbol
  Fkbp11
• Name
  FK506 binding protein 11
• Synonyms
  1110002O23Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1913370
  NCBI Gene: 66120
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr15:98724373-98728198 bp, - strand
• From Ensembl annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    3826 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 54.65 cM, cytoband F2
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  FKBP11, FK506 binding protein 11

• Vertebrate Orthologs
  9

• Human Ortholog
  FKBP11, FK506 binding protein 11
  Orthology source: HomoloGene, HGNC
• Synonyms
  FKBP19
• Links
  HGNC:18624

  NCBI Gene ID: 51303

  neXtProt AC: NX_Q9NYL4

  UniProt: Q9NYL4

  
  
• Chr Location
  12q13.12; chr12:48921959-48925547 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 9581
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: FKBP11
• Gene Tree
  Fkbp11
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  26 phenotype references
  

• All Mutations and Alleles
  17
• Chemically induced (other)
  1
• Gene trapped
  11
• Radiation induced
  2
• Targeted
  1
• Transgenic
  2
• Genomic Mutations
  3 involving Fkbp11
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  8 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for disruptions of this gene display increased antibody response to antibody challenge and increased inflammatory responses. Measurements of bone density are also increased.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  7
• GO References
  2

• External Resources
  FuncBase

Expression

• Assay Results
  141
• Tissues
  17
• cDNA Data
  51
• Literature Summary
  3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase fkbp11

Sequences &
Gene Models

• All Sequences
  19
• RefSeq
  4
• UniProt
  1
• CCDS
  CCDS27803.1
• UniGene
  30729

• Ensembl
  ENSMUSG00000003355 (Evidence)
• NCBI Gene
  66120

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000003355	Ensembl Gene Model | MGI Sequence Detail	3826	C57BL/6J
transcript	ENSMUST00000003445	Ensembl | MGI Sequence Detail	731	Not Applicable
polypeptide	ENSMUSP00000003445	Ensembl | MGI Sequence Detail	201	Not Applicable

Polymorphisms

• SNPs within 2kb
  50 from dbSNP Build 142

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000007533 peptidyl-prolyl cis-trans isomerase FKBP11
  (term hierarchy)
• EC
  5.2.1.8
• InterPro Domains
  IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
  IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type

Molecular
Reagents

• All nucleic 51

  cDNA 51

  
  

  Microarray probesets 6

References

• Summaries
  All 46

  Developmental Gene Expression 3

  Diseases 1

  Gene Ontology 2

  Phenotypes 26
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9