Apoa5
Gene Detail

Symbol Name ID

Apoa5 apolipoprotein A-V MGI:1913363

Synonyms

1300007O05Rik, Apoav, RAP3

Feature Type

protein coding gene

Genetic Map

Chromosome 9

25.37 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr9:46268633-46271919 bp, + strand From VEGA annotation of GRCm38   3287 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Apoa5

Human homologs

Human Homolog		APOA5, apolipoprotein A-V
NCBI Gene ID		116519
neXtProt AC		NX_Q6Q788
Human Synonyms		APOAV, RAP3
Human Chr (Location)		11q23; chr11:116660086-116663136 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human APOA5

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutation of this gene results in increased triglyceride and VLDL cholesterol levels.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	acylglycerol homeostasis, cholesterol homeostasis, ...
Component	chylomicron, extracellular region, ...
Function	enzyme activator activity, enzyme binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(181)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(181) cDNA(181)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000028704 (Evidence)
Ensembl Gene Model	ENSMUSG00000032079 (Evidence)
Entrez Gene	66113 (Evidence)
UniGene	29738
DFCI	TC1575460
DoTS	DT.536273, DT.94366441, DT.99842157
NIA Mouse Gene Index	U010436
Consensus CDS Project	CCDS23143.1
International Mouse Knockout Project Status	Apoa5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028704	VEGA Gene Model | MGI Sequence Detail	3287	C57BL/6J
transcript	OTTMUST00000071088	VEGA | MGI Sequence Detail	2515	Not Applicable
polypeptide	OTTMUSP00000036352	VEGA | MGI Sequence Detail	368	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013326	Apolipoprotein
InterPro	IPR000074	Apolipoprotein A1/A4/E
Protein Ontology	PR:000004144	apolipoprotein A-V

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:168555 Bartelt A, et al., Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011 Feb;17(2):200-5
All references(46)