Ube2d3 MGI Mouse Gene Detail - MGI:1913355 - ubiquitin-conjugating enzyme E2D 3

Symbol

Ube2d3
Name

ubiquitin-conjugating enzyme E2D 3
Synonyms

1100001F19Rik, 9430029A22Rik

Feature Type

protein coding gene
IDs

MGI:1913355
NCBI Gene: 66105
Alliance

genome feature page
Transcription Start Sites

19 TSS

Sequence Map

Chr3:135143993-135173975 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 62.56 cM
Mapping Data

2 experiments

SNPs within 2kb

547 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913355	protein coding gene	Chr3:135143910-135173975 (+)
129S1/SvImJ	ENSMUSG00200002686	protein coding gene	Chr3:131914486-131944554 (+)
A/J	ENSMUSG00195004214	protein coding gene	Chr3:132041630-132071678 (+)
AKR/J	ENSMUSG00220022375	protein coding gene	Chr3:130493569-130523611 (+)
BALB/cJ	ENSMUSG00180011698	protein coding gene	Chr3:131963402-131993452 (+)
C3H/HeJ	ENSMUSG00175018182	protein coding gene	Chr3:131564345-131594396 (+)
C57BL/6NJ	ENSMUSG00215016555	protein coding gene	Chr3:132301642-132331692 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025659	protein coding gene	Chr3:128703030-128730917 (+)
CAST/EiJ	ENSTCUG00005003646	protein coding gene	Chr3:132632843-132662793 (+)
CBA/J	ENSMUSG00210031856	protein coding gene	Chr3:132154222-132184269 (+)
DBA/2J	ENSMUSG00185003324	protein coding gene	Chr3:132792078-132822133 (+)
FVB/NJ	ENSMUSG00205017565	protein coding gene	Chr3:131106058-131136112 (+)
JF1/MsJ	ENSUMUG00000018678	protein coding gene	Chr3:131520584-131550606 (+)
LP/J	ENSMUSG00230002147	protein coding gene	Chr3:134728516-134758586 (+)
NOD/ShiLtJ	ENSMUSG00190004441	protein coding gene	Chr3:133171010-133201059 (+)
NZO/HlLtJ	ENSMUSG00225005339	protein coding gene	Chr3:137212317-137242357 (+)
PWK/PhJ	ENSLUMG00010014790	protein coding gene	Chr3:131449890-131480030 (+)
SPRET/EiJ	ENSMSPG00010013218	protein coding gene	Chr3:132582881-132613091 (+)
WSB/EiJ	ENSIUOG00005017765	protein coding gene	Chr3:132283520-132313560 (+)

Human Ortholog

UBE2D3, ubiquitin conjugating enzyme E2 D3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2D3, ubiquitin conjugating enzyme E2 D3
Synonyms

E2(17)KB3, UBC4/5, UBCH5C
Links

HGNC:12476

NCBI Gene ID: 7323

UniProt: P61077
Chr Location

4q24; chr4:102793516-102869287 (-) GRCh38

MGI Vertebrate Homology

Ube2d3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBE2D3
Gene Tree

Ube2d3

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

67
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Ube2d3
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

37
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

2
cDNA Data

39
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2d3

ZFIN ube2d3

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All Sequences

128
RefSeq

22
UniProt

11
CCDS

CCDS38644.1

Ensembl

ENSMUSG00000078578 (Evidence)
NCBI Gene

66105

			Length	Strain/Species	Flank
genomic	66105	NCBI Gene Model \| MGI Sequence Detail	29983	C57BL/6J	± kb
transcript	NM_001356597	RefSeq \| MGI Sequence Detail	4067	C57BL/6
polypeptide	P61079	UniProt \| EBI \| MGI Sequence Detail	147	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000003154 ubiquitin-conjugating enzyme E2 D3

(term hierarchy)
PDB

9SFP, 9W2M, 9XRL
EC

2.3.2.23, 2.3.2.24
InterPro Domains

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

IPR000608 Ubiquitin-conjugating (UBC), catalytic core domain
GlyGen

P61079 1 site, 1 O-linked glycan (1 site)

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All nucleic 40

cDNA 40

Microarray probesets 12

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MGI:1924549, MGI:2139576

Summaries

All 61

Developmental Gene Expression 1

Diseases 1

Gene Ontology 11

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ube2d3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31809	Chr3:135143875-135143887 (+)	-112 bp
Tssr31810	Chr3:135143905-135143914 (+)	-83 bp
Tssr31811	Chr3:135144041-135144064 (+)	60 bp
Tssr31812	Chr3:135144140-135144151 (+)	153 bp
Tssr31813	Chr3:135144193-135144213 (+)	210 bp
Tssr31814	Chr3:135144235-135144246 (+)	248 bp
Tssr31815	Chr3:135144287-135144301 (+)	301 bp
Tssr31816	Chr3:135144304-135144345 (+)	332 bp
Tssr31817	Chr3:135144483-135144541 (+)	519 bp
Tssr31818	Chr3:135144787-135144814 (+)	808 bp
Tssr31819	Chr3:135144815-135144824 (+)	827 bp
Tssr31820	Chr3:135144850-135144859 (+)	862 bp
Tssr31821	Chr3:135144862-135144935 (+)	906 bp
Tssr31822	Chr3:135145145-135145201 (+)	1,180 bp
Tssr31823	Chr3:135145203-135145230 (+)	1,224 bp
Tssr31824	Chr3:135145231-135145261 (+)	1,253 bp
Tssr31825	Chr3:135161689-135161693 (+)	17,698 bp
Tssr31826	Chr3:135168353-135168367 (+)	24,367 bp
Tssr31827	Chr3:135168720-135168769 (+)	24,752 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24