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Emc3 Gene Detail
Summary
  • Symbol
    Emc3
  • Name
    ER membrane protein complex subunit 3
  • Synonyms
    0610039A15Rik, Tmem111
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913337
    NCBI Gene: 66087
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113514887-113531638 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913337
protein coding gene Chr6:113514874-113531652 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031129
protein coding gene Chr6:116037364-116054132 (-)
A/J MGP_AJ_G0031098
protein coding gene Chr6:111591738-111608507 (-)
AKR/J MGP_AKRJ_G0031029
protein coding gene Chr6:114585560-114602295 (-)
BALB/cJ MGP_BALBcJ_G0031109
protein coding gene Chr6:111537886-111554656 (-)
C3H/HeJ MGP_C3HHeJ_G0030599
protein coding gene Chr6:69692510-69709284 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031568
protein coding gene Chr6:119040146-119056929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028732
protein coding gene Chr6:108619520-108636529 (-)
CAST/EiJ MGP_CASTEiJ_G0030216
protein coding gene Chr6:115037534-115058901 (-)
CBA/J MGP_CBAJ_G0030795
protein coding gene Chr6:123740377-123757119 (-)
DBA/2J MGP_DBA2J_G0030948
protein coding gene Chr6:110672140-110688903 (-)
FVB/NJ MGP_FVBNJ_G0030902
protein coding gene Chr6:109674974-109691778 (-)
LP/J MGP_LPJ_G0031028
protein coding gene Chr6:116071383-116089992 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030936
protein coding gene Chr6:128002423-128019226 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031595
protein coding gene Chr6:114606277-114623054 (-)
PWK/PhJ MGP_PWKPhJ_G0029932
protein coding gene Chr6:109628205-109645545 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029760
protein coding gene Chr6:113418487-113434961 (-)
WSB/EiJ MGP_WSBEiJ_G0030300
protein coding gene Chr6:114977571-114994360 (-)



Homology
more
  • Human Ortholog
    EMC3, ER membrane protein complex subunit 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EMC3, ER membrane protein complex subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    POB, TMEM111
  • Links
    NCBI Gene ID: 55831
    neXtProt AC: NX_Q9P0I2
    UniProt: Q9P0I2

  • Chr Location
    3p25.3; chr3:9962680-10011248 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66087 NCBI Gene Model | MGI Sequence Detail 16752 C57BL/6J ±  kb
transcript NM_175101 RefSeq | MGI Sequence Detail 1958 C57BL/6  
polypeptide Q99KI3 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 111
    cDNA 111

    Microarray probesets 4
Other
Accession IDs
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MGI:1353660, MGI:2141673
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265020 Tang X, et al., EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. J Clin Invest. 2017 Dec 1;127(12):4314-4325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory