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Emc3 Gene Detail
Summary
  • Symbol
    Emc3
  • Name
    ER membrane protein complex subunit 3
  • Synonyms
    0610039A15Rik, Tmem111
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913337
    NCBI Gene: 66087
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113491848-113508599 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913337
 protein coding gene Chr6:113491835-113508613 (-)
129S1/SvImJ ENSMUSG00200023277
 protein coding gene Chr6:110541594-110558373 (-)
A/J ENSMUSG00195014486
 protein coding gene Chr6:110214028-110230808 (-)
AKR/J ENSMUSG00220034673
 protein coding gene Chr6:109140029-109156809 (-)
BALB/cJ ENSMUSG00180002313
 protein coding gene Chr6:110578775-110595558 (-)
C3H/HeJ ENSMUSG00175031419
 protein coding gene Chr6:66810282-66827063 (+)
C57BL/6NJ ENSMUSG00215017885
 protein coding gene Chr6:110573219-110589999 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028732
 protein coding gene Chr6:108619520-108636529 (-)
CAST/EiJ ENSTCUG00005027366
 protein coding gene Chr6:110383574-110400370 (-)
CBA/J ENSMUSG00210020070
 protein coding gene Chr6:110399944-110416724 (-)
DBA/2J ENSMUSG00185017851
 protein coding gene Chr6:110776315-110793097 (-)
FVB/NJ ENSMUSG00205016716
 protein coding gene Chr6:109474045-109490832 (-)
JF1/MsJ ENSUMUG00000011473
 protein coding gene Chr6:109503068-109519832 (-)
LP/J ENSMUSG00230046492
 protein coding gene Chr6:112042898-112059677 (-)
NOD/ShiLtJ ENSMUSG00190017610
 protein coding gene Chr6:109978023-109994808 (-)
NZO/HlLtJ ENSMUSG00225046134
 protein coding gene Chr6:113990593-114007375 (-)
PWK/PhJ ENSLUMG00010026444
 protein coding gene Chr6:108996477-109013270 (-)
SPRET/EiJ ENSMSPG00010034786
 protein coding gene Chr6:111766309-111782814 (-)
WSB/EiJ ENSIUOG00005024310
 protein coding gene Chr6:110724580-110741372 (-)



Homology
more
  • Human Ortholog
    EMC3, ER membrane protein complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EMC3, ER membrane protein complex subunit 3
  • Synonyms
    POB, TMEM111
  • Links
    NCBI Gene ID: 55831
    UniProt: Q9P0I2

  • Chr Location
    3p25.3; chr3:9962682-10011202 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an inducible conditional allele exhibit thin retinal outer nuclear layer with retinal degeneration and reduced Rho trafficking to the outer segment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    4
  • cDNA Data
    110
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66087 NCBI Gene Model | MGI Sequence Detail 16752 C57BL/6J ±  kb
    transcript NM_175101 RefSeq | MGI Sequence Detail 1958 C57BL/6  
    polypeptide Q99KI3 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 111
      Primer pair 1
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1353660, MGI:2141673
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory