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Emc3 Gene Detail
Summary
  • Symbol
    Emc3
  • Name
    ER membrane protein complex subunit 3
  • Synonyms
    0610039A15Rik, Tmem111
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913337
    NCBI Gene: 66087
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113514887-113531638 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913337
protein coding gene Chr6:113514874-113531652 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031129
protein coding gene Chr6:116037364-116054132 (-)
A/J MGP_AJ_G0031098
protein coding gene Chr6:111591738-111608507 (-)
AKR/J MGP_AKRJ_G0031029
protein coding gene Chr6:114585560-114602295 (-)
BALB/cJ MGP_BALBcJ_G0031109
protein coding gene Chr6:111537886-111554656 (-)
C3H/HeJ MGP_C3HHeJ_G0030599
protein coding gene Chr6:69692510-69709284 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031568
protein coding gene Chr6:119040146-119056929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028732
protein coding gene Chr6:108619520-108636529 (-)
CAST/EiJ MGP_CASTEiJ_G0030216
protein coding gene Chr6:115037534-115058901 (-)
CBA/J MGP_CBAJ_G0030795
protein coding gene Chr6:123740377-123757119 (-)
DBA/2J MGP_DBA2J_G0030948
protein coding gene Chr6:110672140-110688903 (-)
FVB/NJ MGP_FVBNJ_G0030902
protein coding gene Chr6:109674974-109691778 (-)
LP/J MGP_LPJ_G0031028
protein coding gene Chr6:116071383-116089992 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030936
protein coding gene Chr6:128002423-128019226 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031595
protein coding gene Chr6:114606277-114623054 (-)
PWK/PhJ MGP_PWKPhJ_G0029932
protein coding gene Chr6:109628205-109645545 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029760
protein coding gene Chr6:113418487-113434961 (-)
WSB/EiJ MGP_WSBEiJ_G0030300
protein coding gene Chr6:114977571-114994360 (-)



Homology
more
  • Human Ortholog
    EMC3, ER membrane protein complex subunit 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EMC3, ER membrane protein complex subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    POB, TMEM111
  • Links
    NCBI Gene ID: 55831
    neXtProt AC: NX_Q9P0I2
    UniProt: Q9P0I2

  • Chr Location
    3p25.3; chr3:9962680-10011248 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66087 NCBI Gene Model | MGI Sequence Detail 16752 C57BL/6J ±  kb
transcript NM_175101 RefSeq | MGI Sequence Detail 1958 C57BL/6  
polypeptide Q99KI3 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 111
    cDNA 111

    Microarray probesets 4
Other
Accession IDs
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MGI:1353660, MGI:2141673
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265020 Tang X, et al., EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. J Clin Invest. 2017 Dec 1;127(12):4314-4325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory