About   Help   FAQ
Tsen34
Gene Detail
 Symbol
Name
ID
Tsen34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
MGI:1913328
Synonyms 0610027F08Rik, Leng5
Feature Type protein coding gene
Genetic Map
Chromosome 7
2.13 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:3693375-3701023 bp, + strand
From VEGA annotation of GRCm38

  7649 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44182  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: tRNA-splicing endonuclease, SEN34 subunit
Gene Tree: Tsen34

Human
homologs
Human Homolog TSEN34, TSEN34 tRNA splicing endonuclease subunit
NCBI Gene ID 79042
neXtProt AC  NX_Q9BSV6
Human Synonyms  LENG5, PCH2C, SEN34, SEN34L
Human Chr (Location)  19q13.4; chr19:54190266-54194536 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TSEN34
Alleles
and
phenotypes
All alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from APF )
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process mRNA processing, tRNA processing, ...
Component nucleus, tRNA-intron endonuclease complex
Function lyase activity, nuclease activity, ...
External Resources: FuncBase
Expression
cDNA source data(88)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(89) cDNA(89)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023033 (Evidence)
Ensembl Gene ModelENSMUSG00000035585 (Evidence)
Entrez Gene66078 (Evidence)
UniGene379100
DoTSDT.101390652, DT.111003827, DT.91359060, DT.94183574, DT.94183620, DT.99859905
EC4.6.1.16
Consensus CDS ProjectCCDS20725.1, CCDS51966.1
International Mouse Knockout Project StatusTsen34
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023033 VEGA Gene Model | MGI Sequence Detail 7649 C57BL/6J ±  kb
transcript OTTMUST00000055495 VEGA | MGI Sequence Detail 1778 Not Applicable 
polypeptide OTTMUSP00000026575 VEGA | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(19) UniProt(7)
Polymorphisms SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011856 tRNA endonuclease-like domain
InterPro IPR006677 tRNA intron endonuclease, catalytic domain-like
InterPro IPR006676 tRNA-splicing endonuclease
InterPro IPR016690 tRNA-splicing endonuclease, SEN34 subunit
Protein Ontology PR:000016716 tRNA-splicing endonuclease subunit Sen34
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory