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Tsen34 Gene Detail
Summary
  • Symbol
    Tsen34
  • Name
    tRNA splicing endonuclease subunit 34
  • Synonyms
    0610027F08Rik, Leng5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913328
    NCBI Gene: 66078
  • Gene Overview
    MyGene.info: TSEN34
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:3693436-3701035 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 2.13 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913328
protein coding gene Chr7:3692863-3701035 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031529
protein coding gene Chr7:622155-630346 (+)
A/J MGP_AJ_G0031504
protein coding gene Chr7:559265-567327 (+)
AKR/J MGP_AKRJ_G0031432
protein coding gene Chr7:575169-582754 (+)
BALB/cJ MGP_BALBcJ_G0031512
protein coding gene Chr7:574380-582476 (+)
C3H/HeJ MGP_C3HHeJ_G0031232
protein coding gene Chr7:582116-589690 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031972
protein coding gene Chr7:597911-606708 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029099
protein coding gene Chr7:465218-472901 (+)
CAST/EiJ MGP_CASTEiJ_G0030601
protein coding gene Chr7:576204-583955 (+)
CBA/J MGP_CBAJ_G0031192
protein coding gene Chr7:723670-731998 (+)
DBA/2J MGP_DBA2J_G0031349
protein coding gene Chr7:558731-566346 (+)
FVB/NJ MGP_FVBNJ_G0031301
protein coding gene Chr7:551131-558725 (+)
LP/J MGP_LPJ_G0031434
protein coding gene Chr7:636954-645019 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031340
protein coding gene Chr7:619853-629194 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032006
protein coding gene Chr7:567438-576614 (+)
PWK/PhJ MGP_PWKPhJ_G0030328
protein coding gene Chr7:703430-712936 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030152
protein coding gene Chr7:634026-642134 (+)
WSB/EiJ MGP_WSBEiJ_G0030695
protein coding gene Chr7:569160-576752 (+)



Homology
more
  • Human Ortholog
    TSEN34, tRNA splicing endonuclease subunit 34
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TSEN34, tRNA splicing endonuclease subunit 34
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LENG5, PCH2C, SEN34, SEN34L
  • Links
    NCBI Gene ID: 79042
    neXtProt AC: NX_Q9BSV6
    UniProt: Q9BSV6

  • Chr Location
    19q13.42; chr19:54189517-54194536 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TSEN34 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66078 NCBI Gene Model | MGI Sequence Detail 7600 C57BL/6J ±  kb
transcript NM_001164204 RefSeq | MGI Sequence Detail 1555 C57BL/6  
polypeptide Q8BMZ5 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • EC
  • InterPro Domains
    IPR011856 tRNA endonuclease-like domain superfamily
    IPR006677 tRNA intron endonuclease, catalytic domain-like
    IPR036167 tRNA intron endonuclease, catalytic domain-like superfamily
    IPR006676 tRNA-splicing endonuclease
    IPR016690 tRNA-splicing endonuclease, SEN34 subunit
Molecular
Reagents
less
  • All nucleic 90
    cDNA 90

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory