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Tsen34 Gene Detail
Summary
  • Symbol
    Tsen34
  • Name
    tRNA splicing endonuclease subunit 34
  • Synonyms
    0610027F08Rik, Leng5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913328
    NCBI Gene: 66078
  • Gene Overview
    MyGene.info: TSEN34
Location & Maps
more
  • Genetic Map
    Chromosome 7, 2.13 cM, cytoband A1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TSEN34, tRNA splicing endonuclease subunit 34
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TSEN34, tRNA splicing endonuclease subunit 34
    Orthology source: HomoloGene
  • Synonyms
    LENG5, PCH2C, SEN34, SEN34L
  • Links
    NCBI Gene ID: 79042
    neXtProt AC: NX_Q9BSV6

  • Chr Location
    19q13.4; chr19:54189517-54194536 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TSEN34 associations

Human Disease Mouse Models
       Pontocerebellar Hypoplasia, Type 2c; PCH2C   OMIM: 612390
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    3
  • Targeted
    2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023033 VEGA Gene Model | MGI Sequence Detail 8162 C57BL/6J ±  kb
transcript OTTMUST00000055495 VEGA | MGI Sequence Detail 1779 Not Applicable  
polypeptide OTTMUSP00000026575 VEGA | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    79 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000016716 tRNA-splicing endonuclease subunit Sen34
  • EC
  • InterPro Domains
    IPR011856 tRNA endonuclease-like domain
    IPR006677 tRNA intron endonuclease, catalytic domain-like
    IPR006676 tRNA-splicing endonuclease
    IPR016690 tRNA-splicing endonuclease, SEN34 subunit
Molecular
Reagents
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  • All nucleic 89
    cDNA 89

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory