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Chchd3 Gene Detail
Summary
  • Symbol
    Chchd3
  • Name
    coiled-coil-helix-coiled-coil-helix domain containing 3
  • Synonyms
    0610041L09Rik, 1700039J09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913325
    NCBI Gene: 66075
Location & Maps
more
  • Sequence Map
    Chr6:32790976-33060260 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      269285 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 13.97 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CHCHD3, coiled-coil-helix-coiled-coil-helix domain containing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHCHD3, coiled-coil-helix-coiled-coil-helix domain containing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Mic19, MINOS3, PPP1R22
  • Links
    NCBI Gene ID: 54927
    neXtProt AC: NX_Q9NX63

  • Chr Location
    7q33; chr7:132784862-133082079 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9851
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CHCHD3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from multigenic genotypes
    8 phenotype references
  • All Mutations and Alleles
    20
  • Gene trapped
    16
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption exhibit lethality prior to implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014758 VEGA Gene Model | MGI Sequence Detail 269285 C57BL/6J ±  kb
transcript OTTMUST00000035022 VEGA | MGI Sequence Detail 1550 Not Applicable  
polypeptide OTTMUSP00000015630 VEGA | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2178 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000029355 coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial
  • InterPro Domains
    IPR007964 Protein of unknown function DUF737
Molecular
Reagents
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  • All nucleic 147
    cDNA 147

    Microarray probesets 4
Other
Accession IDs
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MGI:1920592, MGI:2141712
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:197125 Darshi M, et al., Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem. 2012 Nov 16;287(47):39480-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory