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Sdhaf2 Gene Detail
Summary
  • Symbol
    Sdhaf2
  • Name
    succinate dehydrogenase complex assembly factor 2
  • Synonyms
    0610038F07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913322
    NCBI Gene: 66072
  • Gene Overview
    MyGene.info: SDHAF2
Location & Maps
more
  • Sequence Map
    Chr19:10500513-10525209 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24697 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SDHAF2, succinate dehydrogenase complex assembly factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SDHAF2, succinate dehydrogenase complex assembly factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C11orf79, PGL2, SDH5
  • Links
    NCBI Gene ID: 54949
    neXtProt AC: NX_Q9NX18

  • Chr Location
    11q12.2; chr11:61430125-61446767 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SDHAF2 associations

Human Disease Mouse Models
       Paragangliomas 2; PGL2   OMIM: 601650
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    16
  • Gene trapped
    12
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024668 Ensembl Gene Model | MGI Sequence Detail 24697 C57BL/6J ±  kb
transcript ENSMUST00000025570 Ensembl | MGI Sequence Detail 3096 Not Applicable  
polypeptide ENSMUSP00000025570 Ensembl | MGI Sequence Detail 164 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    166 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031667 succinate dehydrogenase assembly factor 2, mitochondrial
  • InterPro Domains
    IPR005631 Flavinator of succinate dehydrogenase
    IPR028882 Succinate dehydrogenase assembly factor 2, mitochondrial
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147428, MGI:2147695
References
more
  • Summaries
    All 26
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:203932 Liu J, et al., Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3beta-beta-catenin-mediated lung cancer metastasis. J Biol Chem. 2013 Oct 11;288(41):29965-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory