Gtpbp8 MGI Mouse Gene Detail - MGI:1913317 - GTP-binding protein 8 (putative)

Symbol

Gtpbp8
Name

GTP-binding protein 8 (putative)
Synonyms

0610037H22Rik

Feature Type

protein coding gene
IDs

MGI:1913317
NCBI Gene: 66067
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:44559242-44566726 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 29.05 cM, cytoband B5
Mapping Data

3 experiments

SNPs within 2kb

228 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913317	protein coding gene	Chr16:44557131-44566726 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022842	protein coding gene	Chr16:43503162-43512757 (-)
A/J	MGP_AJ_G0022807	protein coding gene	Chr16:41554930-41564505 (-)
AKR/J	MGP_AKRJ_G0022779	protein coding gene	Chr16:42881063-42890610 (-)
BALB/cJ	MGP_BALBcJ_G0022808	protein coding gene	Chr16:41545787-41555342 (-)
C3H/HeJ	MGP_C3HHeJ_G0022572	protein coding gene	Chr16:43083705-43093647 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023255	protein coding gene	Chr16:44491692-44502684 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020770	protein coding gene	Chr16:41594966-41604355 (-)
CAST/EiJ	MGP_CASTEiJ_G0022098	protein coding gene	Chr16:43278334-43287852 (-)
CBA/J	MGP_CBAJ_G0022543	protein coding gene	Chr16:46380615-46390211 (-)
DBA/2J	MGP_DBA2J_G0022675	protein coding gene	Chr16:41287363-41297105 (-)
FVB/NJ	MGP_FVBNJ_G0022650	protein coding gene	Chr16:41245140-41254882 (-)
LP/J	MGP_LPJ_G0022743	protein coding gene	Chr16:43231458-43241003 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022669	protein coding gene	Chr16:45759032-45769583 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023270	protein coding gene	Chr16:42912340-42921935 (-)
PWK/PhJ	MGP_PWKPhJ_G0021838	protein coding gene	Chr16:41666306-41675895 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021669	protein coding gene	Chr16:42821085-42834319 (-)
WSB/EiJ	MGP_WSBEiJ_G0022142	protein coding gene	Chr16:43007463-43017058 (-)

Human Ortholog

GTPBP8, GTP binding protein 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GTPBP8, GTP binding protein 8
Synonyms

HSPC135, MRX8
Links

HGNC:25007

NCBI Gene ID: 29083

UniProt: Q8N3Z3
Chr Location

3q13.2; chr3:112990978-113015060 (+) GRCh38

MGI Vertebrate Homology

Gtpbp8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GTPBP8
Gene Tree

Gtpbp8

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

600
Tissues

3
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gtpbp8

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All Sequences

54
RefSeq

6
UniProt

4
CCDS

CCDS28188.1, CCDS49855.1

Ensembl

ENSMUSG00000022668 (Evidence)
NCBI Gene

66067

			Length	Strain/Species	Flank
genomic	66067	NCBI Gene Model \| MGI Sequence Detail	7485	C57BL/6J	± kb
transcript	NM_025332	RefSeq \| MGI Sequence Detail	1318	C57BL/6
polypeptide	Q9CY28	UniProt \| EBI \| MGI Sequence Detail	285	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008338 GTP-binding protein 8

(term hierarchy)
InterPro Domains

IPR052279 EngB GTPase

IPR030393 EngB-type guanine nucleotide-binding (G) domain

IPR006073 GTP binding domain

IPR019987 GTP-binding protein, ribosome biogenesis, YsxC

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000795 Translational (tr)-type GTP-binding domain

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 6

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:332918 Cai S, et al., Transcriptomic analysis of the upper lip and primary palate development in mice. Front Genet. 2022;13:1039850

TSS for Gtpbp8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141202	Chr16:44566700-44566731 (-)	10 bp
Tssr141201	Chr16:44566673-44566682 (-)	48 bp
Tssr141200	Chr16:44566641-44566663 (-)	74 bp
Tssr141199	Chr16:44566616-44566636 (-)	100 bp
Tssr141198	Chr16:44566593-44566604 (-)	127 bp
Tssr141197	Chr16:44566294-44566317 (-)	420 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/08/2026 MGI 6.24