Hsd17b14 MGI Mouse Gene Detail - MGI:1913315 - hydroxysteroid (17-beta) dehydrogenase 14

Symbol

Hsd17b14
Name

hydroxysteroid (17-beta) dehydrogenase 14
Synonyms

0610039E24Rik, Dhrs10, retSDR3

Feature Type

protein coding gene
IDs

MGI:1913315
NCBI Gene: 66065
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr7:45204345-45216745 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.35 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

828 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913315	protein coding gene	Chr7:45204317-45217176 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032230	protein coding gene	Chr7:45840652-45862302 (+)
A/J	MGP_AJ_G0032209	protein coding gene	Chr7:44945537-44958311 (+)
AKR/J	MGP_AKRJ_G0032145	protein coding gene	Chr7:46196315-46209119 (+)
BALB/cJ	MGP_BALBcJ_G0032221	protein coding gene	Chr7:44939341-44953399 (+)
C3H/HeJ	MGP_C3HHeJ_G0031936	protein coding gene	Chr7:46685463-46698479 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032713	protein coding gene	Chr7:48104576-48118536 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029727	protein coding gene	Chr7:47489465-47502828 (+)
CAST/EiJ	MGP_CASTEiJ_G0031265	protein coding gene	Chr7:38104382-38119050 (+)
CBA/J	MGP_CBAJ_G0031901	protein coding gene	Chr7:49696850-49714731 (+)
DBA/2J	MGP_DBA2J_G0032059	protein coding gene	Chr7:44609989-44623066 (+)
FVB/NJ	MGP_FVBNJ_G0032011	protein coding gene	Chr7:44401346-44412749 (+)
LP/J	MGP_LPJ_G0032137	protein coding gene	Chr7:46540615-46561921 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032047	protein coding gene	Chr7:48389979-48402682 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032729	protein coding gene	Chr7:45405952-45420922 (+)
PWK/PhJ	MGP_PWKPhJ_G0030987	protein coding gene	Chr7:37990773-38005191 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030825	protein coding gene	Chr7:33424657-33440600 (+)
WSB/EiJ	MGP_WSBEiJ_G0031382	protein coding gene	Chr7:45907262-45922185 (+)

Human Ortholog

HSD17B14, hydroxysteroid 17-beta dehydrogenase 14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSD17B14, hydroxysteroid 17-beta dehydrogenase 14
Synonyms

DHRS10, retSDR3, SDR47C1
Links

HGNC:23238

NCBI Gene ID: 51171

UniProt: Q9BPX1
Chr Location

19q13.33; chr19:48813018-48836510 (-) GRCh38

MGI Vertebrate Homology

Hsd17b14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSD17B14
Gene Tree

Hsd17b14

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

226
Endonuclease-mediated

1
Gene trapped

222
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

141 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

In a high-throughput phenotyping screen, male null mice exhibit infertility, decreased sperm production, testicular degeneration and an increased anxiety-like response to stress-induced hyperthermia. Homozygous null mice also show an increase in serum IgG2a in response to antigen challenge.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

8
UniProt

6
CCDS

CCDS21251.2

Ensembl

ENSMUSG00000030825 (Evidence)
NCBI Gene

66065

			Length	Strain/Species	Flank
genomic	66065	NCBI Gene Model \| MGI Sequence Detail	12401	C57BL/6J	± kb
transcript	NM_025330	RefSeq \| MGI Sequence Detail	1365	C57BL/6
polypeptide	E9Q3D4	UniProt \| EBI \| MGI Sequence Detail	273	Not Applicable

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UniProt

6 Sequences
EC

1.1.1.122
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 10

Genomic 1

cDNA 9

Microarray probesets 4

Summaries

All 30

Gene Ontology 3

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55

TSS for Hsd17b14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66560	Chr7:45204255-45204260 (+)	-87 bp
Tssr66561	Chr7:45204339-45204346 (+)	-2 bp
Tssr66562	Chr7:45204350-45204361 (+)	11 bp
Tssr66563	Chr7:45204372-45204385 (+)	34 bp
Tssr66564	Chr7:45204416-45204431 (+)	79 bp
Tssr66565	Chr7:45206961-45206972 (+)	2,622 bp
Tssr66566	Chr7:45206975-45206986 (+)	2,636 bp
Tssr66567	Chr7:45208594-45208635 (+)	4,270 bp
Tssr66568	Chr7:45208635-45208662 (+)	4,304 bp
Tssr66569	Chr7:45208780-45208793 (+)	4,442 bp
Tssr66570	Chr7:45208797-45208809 (+)	4,458 bp
Tssr66571	Chr7:45208810-45208815 (+)	4,468 bp
Tssr66572	Chr7:45212449-45212481 (+)	8,120 bp
Tssr66573	Chr7:45214443-45214464 (+)	10,109 bp
Tssr66574	Chr7:45214553-45214565 (+)	10,214 bp
Tssr66575	Chr7:45214590-45214615 (+)	10,258 bp
Tssr66576	Chr7:45214747-45214762 (+)	10,410 bp
Tssr66577	Chr7:45216075-45216086 (+)	11,736 bp
Tssr66578	Chr7:45216146-45216160 (+)	11,808 bp
Tssr66579	Chr7:45216215-45216229 (+)	11,877 bp
Tssr66580	Chr7:45216334-45216345 (+)	11,995 bp
Tssr66581	Chr7:45216385-45216397 (+)	12,046 bp
Tssr66582	Chr7:45216443-45216477 (+)	12,115 bp
Tssr66583	Chr7:45216504-45216520 (+)	12,167 bp
Tssr66584	Chr7:45216583-45216615 (+)	12,254 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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