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Hsd17b14 Gene Detail
Summary
  • Symbol
    Hsd17b14
  • Name
    hydroxysteroid (17-beta) dehydrogenase 14
  • Synonyms
    0610039E24Rik, Dhrs10, retSDR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913315
    NCBI Gene: 66065
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45554856-45567321 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.35 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913315
 protein coding gene Chr7:45554856-45567752 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032230
 protein coding gene Chr7:45840652-45862302 (+)
A/J MGP_AJ_G0032209
 protein coding gene Chr7:44945537-44958311 (+)
AKR/J MGP_AKRJ_G0032145
 protein coding gene Chr7:46196315-46209119 (+)
BALB/cJ MGP_BALBcJ_G0032221
 protein coding gene Chr7:44939341-44953399 (+)
C3H/HeJ MGP_C3HHeJ_G0031936
 protein coding gene Chr7:46685463-46698479 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032713
 protein coding gene Chr7:48104576-48118536 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029727
 protein coding gene Chr7:47489465-47502828 (+)
CAST/EiJ MGP_CASTEiJ_G0031265
 protein coding gene Chr7:38104382-38119050 (+)
CBA/J MGP_CBAJ_G0031901
 protein coding gene Chr7:49696850-49714731 (+)
DBA/2J MGP_DBA2J_G0032059
 protein coding gene Chr7:44609989-44623066 (+)
FVB/NJ MGP_FVBNJ_G0032011
 protein coding gene Chr7:44401346-44412749 (+)
LP/J MGP_LPJ_G0032137
 protein coding gene Chr7:46540615-46561921 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032047
 protein coding gene Chr7:48389979-48402682 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032729
 protein coding gene Chr7:45405952-45420922 (+)
PWK/PhJ MGP_PWKPhJ_G0030987
 protein coding gene Chr7:37990773-38005191 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030825
 protein coding gene Chr7:33424657-33440600 (+)
WSB/EiJ MGP_WSBEiJ_G0031382
 protein coding gene Chr7:45907262-45922185 (+)



Homology
more
  • Human Ortholog
    HSD17B14, hydroxysteroid 17-beta dehydrogenase 14
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HSD17B14, hydroxysteroid 17-beta dehydrogenase 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHRS10, retSDR3, SDR47C1
  • Links
    NCBI Gene ID: 51171
    neXtProt AC: NX_Q9BPX1
    UniProt: Q9BPX1

  • Chr Location
    19q13.33; chr19:48813014-48836688 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
In a high-throughput phenotyping screen, male null mice exhibit infertility, decreased sperm production, testicular degeneration and an increased anxiety-like response to stress-induced hyperthermia. Homozygous null mice also show an increase in serum IgG2a in response to antigen challenge.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    9
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66065 NCBI Gene Model | MGI Sequence Detail 12466 C57BL/6J ±  kb
transcript NM_025330 RefSeq | MGI Sequence Detail 1365 C57BL/6  
polypeptide NP_079606 RefSeq | MGI Sequence Detail 273 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR036291 NAD(P)-binding domain superfamily
    IPR020904 Short-chain dehydrogenase/reductase, conserved site
    IPR002347 Short-chain dehydrogenase/reductase SDR
Molecular
Reagents
less
  • All nucleic 10
    Genomic 1
    cDNA 9

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/15/2019
MGI 6.14 		The Jackson Laboratory