Tmem176a MGI Mouse Gene Detail - MGI:1913308

Symbol

Tmem176a
Name

transmembrane protein 176A
Synonyms

0610011I04Rik

Feature Type

protein coding gene
IDs

MGI:1913308
NCBI Gene: 66058
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr6:48818417-48822298 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.75 cM
Mapping Data

2 experiments

SNPs within 2kb

162 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913308	protein coding gene	Chr6:48817853-48824005 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030714	protein coding gene	Chr6:47810404-47817834 (+)
A/J	MGP_AJ_G0030685	protein coding gene	Chr6:45630829-45636961 (+)
AKR/J	MGP_AKRJ_G0030610	protein coding gene	Chr6:47241639-47247778 (+)
BALB/cJ	MGP_BALBcJ_G0030695	protein coding gene	Chr6:45966843-45973404 (+)
C3H/HeJ	MGP_C3HHeJ_G0030408	protein coding gene	Chr6:47246798-47252887 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031150	protein coding gene	Chr6:48945697-48953781 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028357	protein coding gene	Chr6:43252697-43258857 (+)
CAST/EiJ	MGP_CASTEiJ_G0029812	protein coding gene	Chr6:46963482-46970819 (+)
CBA/J	MGP_CBAJ_G0030383	protein coding gene	Chr6:50953550-50959769 (+)
DBA/2J	MGP_DBA2J_G0030532	protein coding gene	Chr6:45547818-45553958 (+)
FVB/NJ	MGP_FVBNJ_G0030484	protein coding gene	Chr6:45184880-45191209 (+)
LP/J	MGP_LPJ_G0030617	protein coding gene	Chr6:47796270-47804152 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030518	protein coding gene	Chr6:53759503-53765649 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031179	protein coding gene	Chr6:47104032-47110145 (+)
PWK/PhJ	MGP_PWKPhJ_G0029524	protein coding gene	Chr6:45079816-45086378 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029360	protein coding gene	Chr6:46457279-46463350 (+)
WSB/EiJ	MGP_WSBEiJ_G0029889	protein coding gene	Chr6:47103030-47110278 (+)

Human Ortholog

TMEM176A, transmembrane protein 176A

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM176A, transmembrane protein 176A
Synonyms

GS188, HCA112, MS4B1
Links

HGNC:24930

NCBI Gene ID: 55365

UniProt: Q96HP8
Chr Location

7q36.1; chr7:150800403-150805118 (+) GRCh38

MGI Vertebrate Homology

Tmem176a stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: TMEM176A
Gene Tree

Tmem176a

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a deletion allele spanning Tmem176a and Tmem176b exhibit background sensitive survival.

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

56
cDNA Data

188
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

57
RefSeq

4
UniProt

4
CCDS

CCDS39482.1

Ensembl

ENSMUSG00000023367 (Evidence)
NCBI Gene

66058

			Length	Strain/Species	Flank
genomic	66058	NCBI Gene Model \| MGI Sequence Detail	3882	C57BL/6J	± kb
transcript	NM_025326	RefSeq \| MGI Sequence Detail	1064	C57BL/6
polypeptide	Q9DCS1	UniProt \| EBI \| MGI Sequence Detail	244	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032564 transmembrane protein 176A

(term hierarchy)
InterPro Domains

IPR007237 CD20-like family

IPR009281 Transmembrane protein 176A/B

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All nucleic 189

cDNA 188

Primer pair 1

Microarray probesets 5

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MGI:2141581, MGI:2141587

Summaries

All 36

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 5
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tmem176a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56218	Chr6:48818410-48818487 (+)	32 bp
Tssr56219	Chr6:48818491-48818502 (+)	80 bp
Tssr56220	Chr6:48818567-48818578 (+)	156 bp
Tssr56221	Chr6:48819558-48819572 (+)	1,148 bp
Tssr56222	Chr6:48819603-48819614 (+)	1,192 bp
Tssr56223	Chr6:48820883-48820949 (+)	2,499 bp
Tssr56224	Chr6:48821018-48821047 (+)	2,616 bp
Tssr56225	Chr6:48822060-48822091 (+)	3,659 bp
Tssr56226	Chr6:48822092-48822111 (+)	3,685 bp
Tssr56227	Chr6:48822132-48822176 (+)	3,737 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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