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Tmem176a Gene Detail
Summary
  • Symbol
    Tmem176a
  • Name
    transmembrane protein 176A
  • Synonyms
    0610011I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913308
    NCBI Gene: 66058
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48818417-48822298 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913308
 protein coding gene Chr6:48817853-48824005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030714
 protein coding gene Chr6:47810404-47817834 (+)
A/J MGP_AJ_G0030685
 protein coding gene Chr6:45630829-45636961 (+)
AKR/J MGP_AKRJ_G0030610
 protein coding gene Chr6:47241639-47247778 (+)
BALB/cJ MGP_BALBcJ_G0030695
 protein coding gene Chr6:45966843-45973404 (+)
C3H/HeJ MGP_C3HHeJ_G0030408
 protein coding gene Chr6:47246798-47252887 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031150
 protein coding gene Chr6:48945697-48953781 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028357
 protein coding gene Chr6:43252697-43258857 (+)
CAST/EiJ MGP_CASTEiJ_G0029812
 protein coding gene Chr6:46963482-46970819 (+)
CBA/J MGP_CBAJ_G0030383
 protein coding gene Chr6:50953550-50959769 (+)
DBA/2J MGP_DBA2J_G0030532
 protein coding gene Chr6:45547818-45553958 (+)
FVB/NJ MGP_FVBNJ_G0030484
 protein coding gene Chr6:45184880-45191209 (+)
LP/J MGP_LPJ_G0030617
 protein coding gene Chr6:47796270-47804152 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030518
 protein coding gene Chr6:53759503-53765649 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031179
 protein coding gene Chr6:47104032-47110145 (+)
PWK/PhJ MGP_PWKPhJ_G0029524
 protein coding gene Chr6:45079816-45086378 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029360
 protein coding gene Chr6:46457279-46463350 (+)
WSB/EiJ MGP_WSBEiJ_G0029889
 protein coding gene Chr6:47103030-47110278 (+)



Homology
more
  • Human Ortholog
    TMEM176A, transmembrane protein 176A
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM176A, transmembrane protein 176A
  • Synonyms
    GS188, HCA112, MS4B1
  • Links
    NCBI Gene ID: 55365
    neXtProt AC: NX_Q96HP8
    UniProt: Q96HP8

  • Chr Location
    7q36.1; chr7:150800543-150805120 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Mice homozygous for a deletion allele spanning Tmem176a and Tmem176b exhibit background sensitive survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    56
  • cDNA Data
    188
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66058 NCBI Gene Model | MGI Sequence Detail 3882 C57BL/6J ±  kb
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 189
    cDNA 188
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141581, MGI:2141587
References
more
  • Summaries
    All 32
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 1
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:315063 Lancien M, et al., Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells. J Immunol. 2021 Jul 7;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/10/2022
MGI 6.19 		The Jackson Laboratory