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Sdhc Gene Detail
Summary
  • Symbol
    Sdhc
  • Name
    succinate dehydrogenase complex, subunit C, integral membrane protein
  • Synonyms
    0610010E03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913302
    NCBI Gene: 66052
Location & Maps
more
  • Sequence Map
    Chr1:171127165-171150603 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23439 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SDHC, succinate dehydrogenase complex subunit C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SDHC, succinate dehydrogenase complex subunit C
    Orthology source: HomoloGene
  • Synonyms
    CYB560, CYBL, PGL3, QPS1, SDH3
  • Links
    NCBI Gene ID: 6391
    neXtProt AC: NX_Q99643

  • Chr Location
    1q23.3; chr1:161314376-161364751 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human SDHC associations

Human Disease Mouse Models
       Gastrointestinal Stromal Tumor; GIST   OMIM: 606764
Paraganglioma and Gastric Stromal Sarcoma   OMIM: 606864
Paragangliomas 3; PGL3   OMIM: 605373
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    212
  • Chemically induced (other)
    2
  • Gene trapped
    207
  • Targeted
    3
  • Genomic Mutations
    2 involving Sdhc
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021661 VEGA Gene Model | MGI Sequence Detail 23439 C57BL/6J ±  kb
transcript OTTMUST00000051420 VEGA | MGI Sequence Detail 3171 Not Applicable  
polypeptide OTTMUSP00000024190 VEGA | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    315 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014565 succinate dehydrogenase cytochrome b560 subunit, mitochondrial
  • InterPro Domains
    IPR014314 Succinate dehydrogenase, cytochrome b556 subunit
    IPR018495 Succinate dehydrogenase, cytochrome b subunit, conserved site
    IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit
Molecular
Reagents
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  • All nucleic 326
    cDNA 325
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2138200, MGI:2138435
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory