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Sostdc1 Gene Detail
Summary
  • Symbol
    Sostdc1
  • Name
    sclerostin domain containing 1
  • Synonyms
    ectodin, Sostl, USAG-1, Wise
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913292
    NCBI Gene: 66042
  • Gene Overview
    MyGene.info: SOSTDC1
Location & Maps
more
  • Sequence Map
    Chr12:36314169-36318452 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4284 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 16.82 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SOSTDC1, sclerostin domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOSTDC1, sclerostin domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDA019, DAND7, ECTODIN, USAG1
  • Links
    NCBI Gene ID: 25928
    neXtProt AC: NX_Q6X4U4

  • Chr Location
    7p21.2; chr7:16461481-16465849 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 8 alleles in 9 genetic backgrounds
    11 phenotypes from multigenic genotypes
    4 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Spontaneous
    1
  • Targeted
    12
  • Transgenic
    1
  • Incidental Mutations
Mutations in this gene cause variable defects in many aspects of tooth development, including tooth number, size and cusp pattern. Observed phenotypes may include cranial and palatal defects, neonatal death, altered trigeminal ganglion morphology, and resistance to cisplatin-induced renal injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66042 NCBI Gene Model | MGI Sequence Detail 4284 C57BL/6J ±  kb
transcript NM_025312 RefSeq | MGI Sequence Detail 1751 C57BL/6  
polypeptide Q9CQN4 UniProt | EBI | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    77 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 39
    cDNA 35
    Primer pair 4

    Microarray probesets 5
References
more
  • Summaries
    All 77
    Developmental Gene Expression 44
    Gene Ontology 4
    Phenotypes 24
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:235515 Saito K, et al., Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis. BMC Dev Biol. 2016;16:14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory