Sostdc1 MGI Mouse Gene Detail - MGI:1913292 - sclerostin domain containing 1

Symbol

Sostdc1
Name

sclerostin domain containing 1
Synonyms

ectodin, Sostl, USAG-1, Wise

Feature Type

protein coding gene
IDs

MGI:1913292
NCBI Gene: 66042
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:36364168-36368451 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 16.82 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

77 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913292	protein coding gene	Chr12:36364138-36368451 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019692	protein coding gene	Chr12:34548268-34552551 (+)
A/J	MGP_AJ_G0019658	protein coding gene	Chr12:33460518-33464796 (+)
AKR/J	MGP_AKRJ_G0019629	protein coding gene	Chr12:34498273-34502556 (+)
BALB/cJ	MGP_BALBcJ_G0019636	protein coding gene	Chr12:33661660-33665940 (+)
C3H/HeJ	MGP_C3HHeJ_G0019440	protein coding gene	Chr12:34433360-34437638 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020083	protein coding gene	Chr12:35518579-35522862 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017707	protein coding gene	Chr12:32571858-32576114 (+)
CAST/EiJ	MGP_CASTEiJ_G0018993	protein coding gene	Chr12:29493344-29497626 (+)
CBA/J	MGP_CBAJ_G0019412	protein coding gene	Chr12:36708389-36712670 (+)
DBA/2J	MGP_DBA2J_G0019525	protein coding gene	Chr12:33303138-33307421 (+)
FVB/NJ	MGP_FVBNJ_G0019514	protein coding gene	Chr12:33027111-33031391 (+)
LP/J	MGP_LPJ_G0019595	protein coding gene	Chr12:34626341-34630624 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019550	protein coding gene	Chr12:36365541-36369824 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020123	protein coding gene	Chr12:34023106-34027389 (+)
PWK/PhJ	MGP_PWKPhJ_G0018760	protein coding gene	Chr12:27993957-27998225 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018550	protein coding gene	Chr12:28645071-28649355 (+)
WSB/EiJ	MGP_WSBEiJ_G0019043	protein coding gene	Chr12:34283054-34287336 (+)

Human Ortholog

SOSTDC1, sclerostin domain containing 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SOSTDC1, sclerostin domain containing 1
Synonyms

CDA019, DAND7, ECTODIN, USAG1
Links

HGNC:21748

NCBI Gene ID: 25928

neXtProt AC: NX_Q6X4U4

UniProt: Q6X4U4
Chr Location

7p21.2; chr7:16461481-16530580 (-) GRCh38

MGI Vertebrate Homology

Sostdc1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SOSTDC1
Gene Tree

Sostdc1

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Phenotype Summary

33 phenotypes from 8 alleles in 9 genetic backgrounds
11 phenotypes from multigenic genotypes
4 images
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

3
Spontaneous

1
Targeted

14
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this gene cause variable defects in many aspects of tooth development, including tooth number, size and cusp pattern. Observed phenotypes may include cranial and palatal defects, neonatal death, altered trigeminal ganglion morphology, and resistance to cisplatin-induced renal injury.

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All GO Annotations

33
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1491
Tissues

369
cDNA Data

39
Literature Summary

74

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SOSTDC1

Xenbase sostdc1

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All Sequences

38
RefSeq

2
UniProt

1
CCDS

CCDS25887.1

Ensembl

ENSMUSG00000036169 (Evidence)
NCBI Gene

66042

			Length	Strain/Species	Flank
genomic	66042	NCBI Gene Model \| MGI Sequence Detail	4284	C57BL/6J	± kb
transcript	NM_025312	RefSeq \| MGI Sequence Detail	1751	C57BL/6
polypeptide	Q9CQN4	UniProt \| EBI \| MGI Sequence Detail	206	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015416 sclerostin domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR006207 Cystine knot, C-terminal

IPR029034 Cystine-knot cytokine

IPR008835 Sclerostin/Sclerostin domain-containing protein 1

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All nucleic 52

cDNA 40

Primer pair 8

Other 4

Microarray probesets 5

Summaries

All 127

Developmental Gene Expression 74

Gene Ontology 6

Phenotypes 41
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:338194 Sulic AM, et al., Transcriptomic landscape of early hair follicle and epidermal development. Cell Rep. 2023 Jun 13;42(6):112643

TSS for Sostdc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113233	Chr12:36364136-36364147 (+)	-26 bp
Tssr113234	Chr12:36364159-36364170 (+)	-3 bp
Tssr113235	Chr12:36364215-36364231 (+)	55 bp
Tssr113236	Chr12:36364425-36364437 (+)	263 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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