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Sostdc1 Gene Detail
Summary
  • Symbol
    Sostdc1
  • Name
    sclerostin domain containing 1
  • Synonyms
    ectodin, Sostl, USAG-1, Wise
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913292
    NCBI Gene: 66042
  • Gene Overview
    MyGene.info: SOSTDC1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:36314169-36318452 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4284 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 16.82 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SOSTDC1, sclerostin domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOSTDC1, sclerostin domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDA019, DAND7, ECTODIN, USAG1
  • Links
    NCBI Gene ID: 25928
    neXtProt AC: NX_Q6X4U4
    UniProt: Q6X4U4

  • Chr Location
    7p21.2; chr7:16461481-16496513 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 8 alleles in 9 genetic backgrounds
    11 phenotypes from multigenic genotypes
    4 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene cause variable defects in many aspects of tooth development, including tooth number, size and cusp pattern. Observed phenotypes may include cranial and palatal defects, neonatal death, altered trigeminal ganglion morphology, and resistance to cisplatin-induced renal injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66042 NCBI Gene Model | MGI Sequence Detail 4284 C57BL/6J ±  kb
    transcript NM_025312 RefSeq | MGI Sequence Detail 1751 C57BL/6  
    polypeptide Q9CQN4 UniProt | EBI | MGI Sequence Detail 206 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      77 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 35
      Primer pair 4

      Microarray probesets 5
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 53
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:258789 Jarvinen E, et al., Mesenchymal Wnt/beta-catenin signaling limits tooth number. Development. 2018 Feb 21;145(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory