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Sostdc1
Gene Detail
 Symbol
Name
ID
Sostdc1
sclerostin domain containing 1
MGI:1913292
Synonyms ectodin, Sostl, USAG-1, Wise
Feature Type protein coding gene
Genetic Map
Chromosome 12
16.82 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:36314169-36318452 bp, + strand
From NCBI annotation of GRCm38

  4284 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9154  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sostdc1

Human
homologs
Human Homolog SOSTDC1, sclerostin domain containing 1
NCBI Gene ID 25928
neXtProt AC  NX_Q6X4U4
Human Synonyms  ECTODIN, USAG1
Human Chr (Location)  7p21.1; chr7:16461481-16465849 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Spontaneous(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene cause variable defects in many aspects of tooth development, including tooth number, size and cusp pattern. Observed phenotypes may include cranial and palatal defects, neonatal death, altered trigeminal ganglion morphology, and resistance to cisplatin-induced renal injury.
 
Phenotype Images(2)
Interactions
Sostdc1 interacts with 202 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process hair follicle morphogenesis, mammary gland bud morphogenesis, ...
Component extracellular region, extracellular space
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (493)    Tissues (219)    Images (59)
Theiler Stages: 5, 8, 9, 11, 12, 13, 14, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 426
RT-PCR 67
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(35) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000036169 (Evidence)
Entrez Gene66042 (Evidence)
UniGene43375
DFCITC1579772
DoTSDT.110932542, DT.40143595
NIA Mouse Gene IndexU013871
Consensus CDS ProjectCCDS25887.1
International Mouse Knockout Project StatusSostdc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 66042 NCBI Gene Model | MGI Sequence Detail 4284 C57BL/6J ±  kb
transcript NM_025312 RefSeq | MGI Sequence Detail 1751 C57BL/6 
polypeptide Q9CQN4 UniProt | EBI | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR008835 Sclerostin/Sclerostin domain-containing protein 1
Protein Ontology PR:000015416 sclerostin domain-containing protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203431 Collette NM, et al., Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner. Dev Biol. 2013 Nov 1;383(1):90-105
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory