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Clec1b
Gene Detail
 Symbol
Name
ID
Clec1b
C-type lectin domain family 1, member b
MGI:1913287
Synonyms 1810061I13Rik, Clec2, Clec-2
Feature Type protein coding gene
Genetic Map
Chromosome 6
63.30 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:129397297-129409335 bp, + strand
From VEGA annotation of GRCm38

  12039 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Clec1b

Human
homologs
Human Homolog CLEC1B, C-type lectin domain family 1, member B
NCBI Gene ID 51266
neXtProt AC  NX_Q9P126
Human Synonyms  1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721
Human Chr (Location)  12p13.2; chr12:9990950-10000794 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(1) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit congestion and hemorrhages during embryogenesis with prenatal and postnatal lethality. Mice homozygous for another knock-out allele exhibit blood-lymph mixing, impaired PDPN-Fc-mediated platelet activation, and intestinal edema.
 
Phenotype Images(3)
Interactions
Clec1b interacts with 27 markers (Mir20a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell surface receptor signaling pathway, platelet formation, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function carbohydrate binding, transmembrane signaling receptor activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (47)    Tissues (4)    Images (24)
Theiler Stages: 20, 23
Assay TypeResults
RNA in situ 47
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027001 (Evidence)
Ensembl Gene ModelENSMUSG00000030159 (Evidence)
Entrez Gene56760 (Evidence)
UniGene30700
DFCITC1587460, TC1605067, TC1660830
DoTSDT.40158399, DT.94284031
Consensus CDS ProjectCCDS20586.1, CCDS57452.1, CCDS57453.1
International Mouse Knockout Project StatusClec1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027001 VEGA Gene Model | MGI Sequence Detail 12039 C57BL/6J ±  kb
transcript OTTMUST00000066730 VEGA | MGI Sequence Detail 1090 Not Applicable 
polypeptide OTTMUSP00000033486 VEGA | MGI Sequence Detail 229 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(349 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000005564 C-type lectin domain family 1 member B
References (Earliest) J:64945 Colonna M, et al., Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. Eur J Immunol. 2000 Feb;30(2):697-704
(Latest) J:210759 Benezech C, et al., CLEC-2 is required for development and maintenance of lymph nodes. Blood. 2014 May 15;123(20):3200-7
All references(50)
Other
accession IDs
MGI:1923768, MGI:2141425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory