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Dnase2b
Gene Detail
Symbol

Name
ID
Dnase2b
deoxyribonuclease II beta
MGI:1913283
Synonyms
Dlad, DnaseIIb
Feature Type
protein coding gene
Genetic Map
Chromosome 3
72.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:146580985-146596612 bp, - strand
From VEGA annotation of GRCm38

  15628 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DNASE2B
Protein SuperFamily: deoxyribonuclease II
Gene Tree: Dnase2b

Human
homologs
DNASE2B, deoxyribonuclease II beta
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 58511
neXtProt AC: NX_Q8WZ79

Human Synonyms: DLAD

Human Chr (Location): 1p22.3; chr1:84398532-84415895 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
The inability of homozygous mutant mice to degrade DNA in differentiating lens cells leads to cataract formation in the nucleus lentis. Consequently, mutant mice exhibit an impaired response to light.
 
Interactions
Dnase2b interacts with 163 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process apoptotic DNA fragmentation, DNA metabolic process, ...
Component cytoplasm, extracellular region, ...
Function deoxyribonuclease II activity, endodeoxyribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (29)    Tissues (6)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dnase2b ; ZFIN dnase2b    NEW 
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022298 (Evidence)
Ensembl Gene Model ENSMUSG00000028185 (Evidence)
Entrez Gene 56629 (Evidence)
UniGene 25853
DFCI TC1586887
DoTS DT.101221650, DT.40154820
NIA Mouse Gene Index U024742
EC 3.1.22.1
Consensus CDS Project CCDS17904.1
International Mouse Phenotyping Consortium Status Dnase2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022298 VEGA Gene Model | MGI Sequence Detail 15628 C57BL/6J ±  kb
transcript OTTMUST00000053128 VEGA | MGI Sequence Detail 2566 Not Applicable 
polypeptide OTTMUSP00000025243 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(11) UniProt(1)
Polymorphisms
SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004947 Deoxyribonuclease II
Protein Ontology PR:000006597 deoxyribonuclease-2-beta
References
(Earliest) J:64953 Shiokawa D, et al., DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II. Nucleic Acids Res. 1999 Oct 15;27(20):4083-9
(Latest) J:214812 Chaffee BR, et al., Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly. Development. 2014 Sep;141(17):3388-98
All references(38)
Other
accession IDs
MGI:2139750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory