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Dnase2b
Gene Detail
 Symbol
Name
ID
Dnase2b
deoxyribonuclease II beta
MGI:1913283
Synonyms Dlad, DnaseIIb
Feature Type protein coding gene
Genetic Map
Chromosome 3
72.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:146580985-146596612 bp, - strand
From VEGA annotation of GRCm38

  15628 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: deoxyribonuclease II
Gene Tree: Dnase2b

Human
homologs
Human Homolog DNASE2B, deoxyribonuclease II beta
NCBI Gene ID 58511
neXtProt AC  NX_Q8WZ79
Human Synonyms  DLAD
Human Chr (Location)  1p22.3; chr1:84398532-84415008 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
The inability of homozygous mutant mice to degrade DNA in differentiating lens cells leads to cataract formation in the nucleus lentis. Consequently, mutant mice exhibit an impaired response to light.
 
Interactions
Dnase2b interacts with 164 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process apoptotic DNA fragmentation, DNA catabolic process, endonucleolytic, ...
Component cytoplasm, extracellular region, ...
Function deoxyribonuclease II activity, endodeoxyribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (6)    Images (15)
Theiler Stages: 23
Assay TypeResults
RNA in situ 29
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022298 (Evidence)
Ensembl Gene ModelENSMUSG00000028185 (Evidence)
Entrez Gene56629 (Evidence)
UniGene25853
DFCITC1586887
DoTSDT.101221650, DT.40154820
NIA Mouse Gene IndexU024742
EC3.1.22.1
Consensus CDS ProjectCCDS17904.1
International Mouse Knockout Project StatusDnase2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022298 VEGA Gene Model | MGI Sequence Detail 15628 C57BL/6J ±  kb
transcript OTTMUST00000053128 VEGA | MGI Sequence Detail 2566 Not Applicable 
polypeptide OTTMUSP00000025243 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004947 Deoxyribonuclease II
Protein Ontology PR:000006597 deoxyribonuclease-2-beta
References (Earliest) J:64953 Shiokawa D, et al., DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II. Nucleic Acids Res. 1999 Oct 15;27(20):4083-9
(Latest) J:177496 Wada K, et al., A deletion in a cis element of Foxe3 causes cataracts and microphthalmia in rct mice. Mamm Genome. 2011 Oct 15;
All references(40)
Other
accession IDs
MGI:2139750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory