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Crbn Gene Detail
Summary
  • Symbol
    Crbn
  • Name
    cereblon
  • Synonyms
    2610203G15Rik, 2900045O07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913277
    NCBI Gene: 58799
  • Gene Overview
    MyGene.info: CRBN
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:106780201-106800077 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19877 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 49.24 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CRBN, cereblon
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRBN, cereblon
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRT2, MRT2A
  • Links
    NCBI Gene ID: 51185
    neXtProt AC: NX_Q96SW2
    UniProt: Q96SW2

  • Chr Location
    3p26.2; chr3:3148490-3179717 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9461
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRBN
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CRBN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 4 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired contextual conditioning behavior. Mice homozygous for another knock-out allele exhibit resistance to diet-induced obesity, liver steatosis, glucose intolerance and insulin resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023530 VEGA Gene Model | MGI Sequence Detail 19877 C57BL/6J ±  kb
    transcript OTTMUST00000057356 VEGA | MGI Sequence Detail 2084 Not Applicable  
    polypeptide OTTMUSP00000027657 VEGA | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      257 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914412, MGI:1920153, MGI:2141645
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263691 Akuffo AA, et al., Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. J Biol Chem. 2018 Apr 20;293(16):6187-6200

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory