Crbn
Gene Detail

Symbol Name ID

Crbn cereblon MGI:1913277

Synonyms

2610203G15Rik, 2900045O07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

49.24 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:106778249-106800074 bp, - strand From VEGA annotation of GRCm38   21826 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Crbn

Human homologs

Human Homolog		CRBN, cereblon
NCBI Gene ID		51185
neXtProt AC		NX_Q96SW2
Human Synonyms		MRT2, MRT2A
Human Chr (Location)		3p26.2; chr3:3191317-3221401 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CRBN

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mic homozygous for a knock-out allele exhibit impaired contextual conditioning behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	negative regulation of ion transmembrane transport, negative regulation of protein homooligomerization, ...
Component	Cul4A-RING ubiquitin ligase complex, cytoplasm, ...
Function	ATP-dependent peptidase activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (24)    Images (17)
Theiler Stages: 23, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	26
Western blot	1
RT-PCR	14

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000023530 (Evidence)
Ensembl Gene Model	ENSMUSG00000005362 (Evidence)
Entrez Gene	58799 (Evidence)
NIA Mouse Gene Index	U027701
Consensus CDS Project	CCDS39583.1, CCDS39584.1
International Mouse Knockout Project Status	Crbn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023530	VEGA Gene Model | MGI Sequence Detail	21826	C57BL/6J
transcript	OTTMUST00000057356	VEGA | MGI Sequence Detail	2084	Not Applicable
polypeptide	OTTMUSP00000027657	VEGA | MGI Sequence Detail	445	Not Applicable

All sequences(48) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(249 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003111	Peptidase S16, lon N-terminal
InterPro	IPR015947	PUA-like domain
Protein Ontology	PR:000005851	protein cereblon

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190306 Lee KM, et al., Cereblon inhibits proteasome activity by binding to the 20S core proteasome subunit beta type 4. Biochem Biophys Res Commun. 2012 Oct 26;427(3):618-22
All references(35)

Other accession IDs

MGI:1914412, MGI:1920153, MGI:2141645