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Crbn
Gene Detail
Symbol

Name
ID
Crbn
cereblon
MGI:1913277
Synonyms
2610203G15Rik, 2900045O07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
49.24 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:106778249-106800074 bp, - strand
From VEGA annotation of GRCm38

  21826 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRBN
Gene Tree: Crbn

Human
homologs
CRBN, cereblon
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51185
neXtProt AC: NX_Q96SW2

Human Synonyms: MRT2, MRT2A

Human Chr (Location): 3p26.2; chr3:3149633-3179717 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRBN

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Spontaneous(1) Targeted(8)
Genomic Mutations involving Crbn (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired contextual conditioning behavior. Mice homozygous for another knock-out allele exhibit resistance to diet-induced obesity, liver steatosis, glucose intolerance and insulin resistance.
 
Interactions
Crbn interacts with 238 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (24)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 26
Western blot 1
RT-PCR 14
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crbn ; ZFIN crbn    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000023530 (Evidence)
Ensembl Gene Model ENSMUSG00000005362 (Evidence)
Entrez Gene 58799 (Evidence)
NIA Mouse Gene Index U027701
PDB 3WX1, 3WX2, 4TZC, 4TZU
Consensus CDS Project CCDS39583.1, CCDS39584.1
International Mouse Phenotyping Consortium Status Crbn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023530 VEGA Gene Model | MGI Sequence Detail 21826 C57BL/6J ±  kb
transcript OTTMUST00000057356 VEGA | MGI Sequence Detail 2084 Not Applicable 
polypeptide OTTMUSP00000027657 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003111 Peptidase S16, lon N-terminal
InterPro IPR015947 PUA-like domain
Protein Ontology PR:000005851 protein cereblon
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220336 Lee KM, et al., Depletion of the cereblon gene activates the unfolded protein response and protects cells from ER stress-induced cell death. Biochem Biophys Res Commun. 2015 Feb 27;458(1):34-9
All references(39)
Other
accession IDs
MGI:1914412, MGI:1920153, MGI:2141645

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory