About   Help   FAQ
Crbn
Gene Detail
Symbol

Name
ID
Crbn
cereblon
MGI:1913277
Synonyms
2610203G15Rik, 2900045O07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
49.24 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:106778249-106800074 bp, - strand
From VEGA annotation of GRCm38

  21826 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Crbn

Human
homologs
Human Homolog CRBN, cereblon
NCBI Gene ID 51185
neXtProt AC  NX_Q96SW2
Human Synonyms  MRT2, MRT2A
Human Chr (Location)  3p26.2; chr3:3149633-3179717 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CRBN
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired contextual conditioning behavior. Mice homozygous for another knock-out allele exhibit resistance to diet-induced obesity, liver steatosis, glucose intolerance and insulin resistance.
 
Interactions
Crbn interacts with 239 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (24)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 26
Western blot 1
RT-PCR 14
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023530 (Evidence)
Ensembl Gene ModelENSMUSG00000005362 (Evidence)
Entrez Gene58799 (Evidence)
NIA Mouse Gene IndexU027701
Consensus CDS ProjectCCDS39583.1, CCDS39584.1
International Mouse Knockout Project StatusCrbn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023530 VEGA Gene Model | MGI Sequence Detail 21826 C57BL/6J ±  kb
transcript OTTMUST00000057356 VEGA | MGI Sequence Detail 2084 Not Applicable 
polypeptide OTTMUSP00000027657 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(272 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003111 Peptidase S16, lon N-terminal
InterPro IPR015947 PUA-like domain
Protein Ontology PR:000005851 protein cereblon
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208570 Lee KM, et al., Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice. Diabetes. 2013 Jun;62(6):1855-64
All references(38)
Other
accession IDs
MGI:1914412, MGI:1920153, MGI:2141645

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory