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Ngly1 Gene Detail
Summary
  • Symbol
    Ngly1
  • Name
    N-glycanase 1
  • Synonyms
    1110002C09Rik, Png1, PNGase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913276
    NCBI Gene: 59007
  • Gene Overview
    MyGene.info: NGLY1
Location & Maps
more
  • Sequence Map
    Chr14:16249280-16311926 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62647 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NGLY1, N-glycanase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NGLY1, N-glycanase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDDG, CDG1V, PNG1, PNGase
  • Links
    NCBI Gene ID: 55768
    neXtProt AC: NX_Q96IV0

  • Chr Location
    3p24.2; chr3:25718944-25790039 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NGLY1 associations

Human Disease Mouse Models
       Congenital Disorder of Deglycosylation; CDDG   OMIM: 615273
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 3 alleles in 3 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Endonuclease-mediated
    3
  • Targeted
    5
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023283 VEGA Gene Model | MGI Sequence Detail 62647 C57BL/6J ±  kb
transcript OTTMUST00000056373 VEGA | MGI Sequence Detail 2935 Not Applicable  
polypeptide OTTMUSP00000027088 VEGA | MGI Sequence Detail 651 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    450 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    cDNA 60
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915786
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:65050 Suzuki T, et al., PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase. J Cell Biol. 2000 May 29;149(5):1039-52
  • Latest
    J:217663 Huang C, et al., Endo-beta-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1398-403

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory