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Ngly1 Gene Detail
Summary
  • Symbol
    Ngly1
  • Name
    N-glycanase 1
  • Synonyms
    1110002C09Rik, Png1, PNGase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913276
    NCBI Gene: 59007
  • Gene Overview
    MyGene.info: NGLY1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:16249314-16311926 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    450 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913276
protein coding gene Chr14:16249280-16311926 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021015
protein coding gene Chr14:8872746-8937338 (+)
A/J MGP_AJ_G0020963
protein coding gene Chr14:8612857-8677954 (+)
AKR/J MGP_AKRJ_G0020940
protein coding gene Chr14:8825608-8900425 (+)
BALB/cJ MGP_BALBcJ_G0020966
protein coding gene Chr14:8638883-8709861 (+)
C3H/HeJ MGP_C3HHeJ_G0020750
protein coding gene Chr14:8952911-9017578 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021399
protein coding gene Chr14:9124746-9192481 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018968
protein coding gene Chr14:9232481-9292979 (+)
CAST/EiJ MGP_CASTEiJ_G0020273
protein coding gene Chr14:8823435-8887426 (+)
CBA/J MGP_CBAJ_G0020716
protein coding gene Chr14:9536553-9605908 (+)
DBA/2J MGP_DBA2J_G0020840
protein coding gene Chr14:8550337-8613550 (+)
FVB/NJ MGP_FVBNJ_G0020822
protein coding gene Chr14:8385041-8447868 (+)
LP/J MGP_LPJ_G0020915
protein coding gene Chr14:8934244-9002817 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020848
protein coding gene Chr14:9424313-9492123 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021432
protein coding gene Chr14:8713674-8775706 (+)
PWK/PhJ MGP_PWKPhJ_G0020024
protein coding gene Chr14:8571220-8634357 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019845
protein coding gene Chr14:8938133-9008709 (+)
WSB/EiJ MGP_WSBEiJ_G0020330
protein coding gene Chr14:8763373-8827497 (+)



Homology
more
  • Human Ortholog
    NGLY1, N-glycanase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NGLY1, N-glycanase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDDG, CDG1V, PNG1, PNGase
  • Links
    NCBI Gene ID: 55768
    neXtProt AC: NX_Q96IV0
    UniProt: Q96IV0

  • Chr Location
    3p24.2; chr3:25718944-25790039 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NGLY1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit dysregulation of the endoplasmic reticulum (ER)-associated degradation (ERAD) process.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59007 NCBI Gene Model | MGI Sequence Detail 62613 C57BL/6J ±  kb
    transcript NM_021504 RefSeq | MGI Sequence Detail 2901 C57BL/6  
    polypeptide Q9JI78 UniProt | EBI | MGI Sequence Detail 651 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 61
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915786
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:65050 Suzuki T, et al., PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase. J Cell Biol. 2000 May 29;149(5):1039-52
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory