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Ngly1
Gene Detail
Symbol

Name
ID
Ngly1
N-glycanase 1
MGI:1913276
Synonyms
1110002C09Rik, Png1, PNGase
Feature Type
protein coding gene
Genetic Map
Chromosome 14
7.08 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:16249280-16311926 bp, + strand
From VEGA annotation of GRCm38

  62647 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Gene Tree: Ngly1

Human
homologs
Human Homolog NGLY1, N-glycanase 1
NCBI Gene ID 55768
neXtProt AC  NX_Q96IV0
Human Synonyms  CDG1V, PNG1, PNGase
Human Chr (Location)  3p24.2; chr3:25718944-25790039 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NGLY1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ngly1 interacts with 172 markers (Mir16-1, Mir18, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process glycoprotein catabolic process
Component cytoplasm, nucleus
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (168)    Tissues (16)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(61) cDNA(60) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023283 (Evidence)
Ensembl Gene ModelENSMUSG00000021785 (Evidence)
Entrez Gene59007 (Evidence)
UniGene258381
DFCITC1577540
DoTSDT.101371961, DT.91580306, DT.97391974
NIA Mouse Gene IndexU015337
EC3.5.1.52
PDB2G9F, 2F4O, 2F4M, 2D5U, 2G9G, 2HPL, 2HPJ, 2I74
Consensus CDS ProjectCCDS26832.1
International Mouse Knockout Project StatusNgly1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023283 VEGA Gene Model | MGI Sequence Detail 62647 C57BL/6J ±  kb
transcript OTTMUST00000056373 VEGA | MGI Sequence Detail 2935 Not Applicable 
polypeptide OTTMUSP00000027088 VEGA | MGI Sequence Detail 651 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(454 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR006588 Peptide N glycanase, PAW domain
InterPro IPR018997 PUB domain
InterPro IPR006567 PUG domain
InterPro IPR002931 Transglutaminase-like
Protein Ontology PR:000011196 peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
References
(Earliest) J:65050 Suzuki T, et al., PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase. J Cell Biol. 2000 May 29;149(5):1039-52
(Latest) J:201294 Kamiya Y, et al., NMR characterization of the interaction between the PUB domain of peptide:N-glycanase and ubiquitin-like domain of HR23. FEBS Lett. 2012 Apr 24;586(8):1141-6
All references(38)
Other
accession IDs
MGI:1915786

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory