Rcl1 MGI Mouse Gene Detail - MGI:1913275 - RNA terminal phosphate cyclase-like 1

Symbol

Rcl1
Name

RNA terminal phosphate cyclase-like 1
Synonyms

2310040A02Rik, Rnac, RPCL1

Feature Type

protein coding gene
IDs

MGI:1913275
NCBI Gene: 59028
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:29078761-29121251 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 23.61 cM
Mapping Data

2 experiments

SNPs within 2kb

1454 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913275	protein coding gene	Chr19:29078761-29121329 (+)
129S1/SvImJ	ENSMUSG00200019577	protein coding gene	Chr19:25813742-25856498 (+)
A/J	ENSMUSG00195034444	protein coding gene	Chr19:25964386-26006944 (+)
AKR/J	ENSMUSG00220018738	protein coding gene	Chr19:26029824-26072377 (+)
BALB/cJ	ENSMUSG00180013372	protein coding gene	Chr19:26293131-26335685 (+)
C3H/HeJ	ENSMUSG00175023469	protein coding gene	Chr19:25669313-25711867 (+)
C57BL/6NJ	ENSMUSG00215015716	protein coding gene	Chr19:25709750-25752309 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022853	protein coding gene	Chr19:26122182-26164510 (+)
CAST/EiJ	ENSTCUG00005017307	protein coding gene	Chr19:25531019-25573792 (+)
CBA/J	ENSMUSG00210014223	protein coding gene	Chr19:25900294-25942850 (+)
DBA/2J	ENSMUSG00185024881	protein coding gene	Chr19:26287022-26329577 (+)
FVB/NJ	ENSMUSG00205010077	protein coding gene	Chr19:25681028-25723582 (+)
JF1/MsJ	ENSUMUG00000019474	protein coding gene	Chr19:26491369-26533772 (+)
LP/J	ENSMUSG00230028455	protein coding gene	Chr19:27107400-27153470 (+)
NOD/ShiLtJ	ENSMUSG00190020284	protein coding gene	Chr19:25663787-25706342 (+)
NZO/HlLtJ	ENSMUSG00225029430	protein coding gene	Chr19:30856533-30899089 (+)
PWK/PhJ	ENSLUMG00010032314	protein coding gene	Chr19:25874054-25913580 (+)
SPRET/EiJ	ENSMSPG00010034564	protein coding gene	Chr19:25838399-25881416 (+)
WSB/EiJ	ENSIUOG00005027941	protein coding gene	Chr19:25400717-25443465 (+)

Human Ortholog

RCL1, RNA terminal phosphate cyclase like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RCL1, RNA terminal phosphate cyclase like 1
Synonyms

RNAC, RPCL1
Links

HGNC:17687

NCBI Gene ID: 10171

UniProt: Q9Y2P8
Chr Location

9p24.1; chr9:4792944-4885917 (+) GRCh38

MGI Vertebrate Homology

Rcl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RCL1
Protein SuperFamily

RNA3'_term_phos_cycl_euk
Gene Tree

Rcl1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

701
Tissues

16
cDNA Data

77
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rcl1

ZFIN rcl1

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All Sequences

49
RefSeq

6
UniProt

3
CCDS

CCDS29731.1

Ensembl

ENSMUSG00000024785 (Evidence)
NCBI Gene

59028

			Length	Strain/Species	Flank
genomic	59028	NCBI Gene Model \| MGI Sequence Detail	42491	C57BL/6J	± kb
transcript	NM_021525	RefSeq \| MGI Sequence Detail	1803	C57BL/6
polypeptide	Q9JJT0	UniProt \| EBI \| MGI Sequence Detail	373	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013837 RNA 3'-terminal phosphate cyclase-like protein

(term hierarchy)
InterPro Domains

IPR000228 RNA 3'-terminal phosphate cyclase

IPR023797 RNA 3'-terminal phosphate cyclase domain

IPR037136 RNA 3'-terminal phosphate cyclase domain superfamily

IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta

IPR013791 RNA 3'-terminal phosphate cyclase, insert domain

IPR036553 RNA 3'-terminal phosphate cyclase, insert domain superfamily

IPR020719 RNA 3'-terminal phosphate cyclase-like, conserved site

IPR016443 RNA 3'-terminal phosphate cyclase type 2

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All nucleic 77

cDNA 77

Microarray probesets 3

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MGI:1914206, MGI:2147594, MGI:2147775

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 11
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Rcl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155771	Chr19:29078765-29078776 (+)	10 bp
Tssr155772	Chr19:29078787-29078838 (+)	52 bp
Tssr155773	Chr19:29078841-29078852 (+)	86 bp
Tssr155774	Chr19:29078884-29078897 (+)	130 bp
Tssr155775	Chr19:29099199-29099202 (+)	20,440 bp
Tssr155776	Chr19:29104146-29104163 (+)	25,394 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24