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Kcnmb4 Gene Detail
Summary
  • Symbol
    Kcnmb4
  • Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 4
  • Synonyms
    2900045G12Rik, Slowpoke beta 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913272
    NCBI Gene: 58802
  • Gene Overview
    MyGene.info: KCNMB4
Location & Maps
more
  • Sequence Map
    Chr10:116417861-116473878 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56018 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 64.73 cM, cytoband D2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 27345
    neXtProt AC: NX_Q86W47

  • Chr Location
    12q15; chr12:70366223-70434292 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Kcnmb4
  • Incidental Mutations
    APF
Homozygous mutation of this gene results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036564 VEGA Gene Model | MGI Sequence Detail 56018 C57BL/6J ±  kb
transcript OTTMUST00000093773 VEGA | MGI Sequence Detail 1367 Not Applicable  
polypeptide OTTMUSP00000052095 VEGA | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    493 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009269 calcium-activated potassium channel subunit beta-4
  • InterPro Domains
    IPR003930 Potassium channel, calcium-activated, BK, beta subunit
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920173
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:65054 Weiger TM, et al., A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. J Neurosci. 2000 May 15;20(10):3563-70
  • Latest
    J:232980 Myrick LK, et al., Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):949-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory