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Kcnmb4
Gene Detail
 Symbol
Name
ID
Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
MGI:1913272
Synonyms 2900045G12Rik, Slowpoke beta 4
Feature Type protein coding gene
Genetic Map
Chromosome 10
64.73 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:116417861-116473878 bp, - strand
From VEGA annotation of GRCm38

  56018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8721  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: calcium-activated potassium channel, beta subunit
Gene Tree: Kcnmb4

Human
homologs
Human Homolog KCNMB4, potassium large conductance calcium-activated channel, subfamily M, beta member 4
NCBI Gene ID 27345
neXtProt AC  NX_Q86W47
Human Chr (Location)  12q; chr12:70366282-70434292 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in no obvious phenotype.
 
Interactions
Kcnmb4 interacts with 196 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process action potential, detection of calcium ion, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function calcium-activated potassium channel activity, potassium channel activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (130)    Tissues (28)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 130
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036564 (Evidence)
Ensembl Gene ModelENSMUSG00000054934 (Evidence)
Entrez Gene58802 (Evidence)
DFCITC1586249, TC1621942, TC1698562
Consensus CDS ProjectCCDS24184.1
International Mouse Knockout Project StatusKcnmb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036564 VEGA Gene Model | MGI Sequence Detail 56018 C57BL/6J ±  kb
transcript OTTMUST00000093773 VEGA | MGI Sequence Detail 1367 Not Applicable 
polypeptide OTTMUSP00000052095 VEGA | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(9) UniProt(4)
Polymorphisms SNPs within 2kb(494 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003930 Potassium channel, calcium-activated, BK, beta subunit
Protein Ontology PR:000009269 calcium-activated potassium channel subunit beta-4
References (Earliest) J:65054 Weiger TM, et al., A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. J Neurosci. 2000 May 15;20(10):3563-70
(Latest) J:200818 Wen D, et al., Regulation of BK-alpha expression in the distal nephron by aldosterone and urine pH. Am J Physiol Renal Physiol. 2013 Aug;305(4):F463-76
All references(41)
Other
accession IDs
MGI:1920173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory