Kcnmb4
Gene Detail

Symbol Name ID

Kcnmb4 potassium large conductance calcium-activated channel, subfamily M, beta member 4 MGI:1913272

Synonyms

2900045G12Rik, Slowpoke beta 4

Feature Type

protein coding gene

Genetic Map

Chromosome 10

64.73 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:116417861-116473878 bp, - strand From VEGA annotation of GRCm38   56018 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8721  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Protein SuperFamily: calcium-activated potassium channel, beta subunit
Gene Tree: Kcnmb4

Human homologs

Human Homolog		KCNMB4, potassium large conductance calcium-activated channel, subfamily M, beta member 4
NCBI Gene ID		27345
neXtProt AC		NX_Q86W47
Human Chr (Location)		12q; chr12:70760062-70828072 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous mutation of this gene results in no obvious phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	detection of calcium ion, ion transport, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	calcium-activated potassium channel activity, potassium channel activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (130)    Tissues (28)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	130

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036564 (Evidence)
Ensembl Gene Model	ENSMUSG00000054934 (Evidence)
Entrez Gene	58802 (Evidence)
DFCI	TC1586249, TC1621942, TC1698562
Consensus CDS Project	CCDS24184.1
International Mouse Knockout Project Status	Kcnmb4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036564	VEGA Gene Model | MGI Sequence Detail	56018	C57BL/6J
transcript	OTTMUST00000093773	VEGA | MGI Sequence Detail	1367	Not Applicable
polypeptide	OTTMUSP00000052095	VEGA | MGI Sequence Detail	210	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

SNPs within 2kb(494 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003930	Potassium channel, calcium-activated, BK, beta subunit
Protein Ontology	PR:000009269	calcium-activated potassium channel subunit beta-4

References

(Earliest) J:65054 Weiger TM, et al., A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels. J Neurosci. 2000 May 15;20(10):3563-70
(Latest) J:192642 Bugaj V, et al., Flow-sensitive K+-coupled ATP secretion modulates activity of the epithelial Na+ channel in the distal nephron. J Biol Chem. 2012 Nov 9;287(46):38552-8
All references(38)

Other accession IDs

MGI:1920173