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Kcnmb4 Gene Detail
Summary
  • Symbol
    Kcnmb4
  • Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 4
  • Synonyms
    2900045G12Rik, Slowpoke beta 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913272
    NCBI Gene: 58802
  • Gene Overview
    MyGene.info: KCNMB4
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:116417861-116473542 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 64.73 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913272
protein coding gene Chr10:116417861-116473878 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017745
protein coding gene Chr10:119191261-119252694 (-)
A/J MGP_AJ_G0017721
protein coding gene Chr10:114607822-114665822 (-)
AKR/J MGP_AKRJ_G0017683
protein coding gene Chr10:117929912-117987136 (-)
BALB/cJ MGP_BALBcJ_G0017684
protein coding gene Chr10:115008474-115067702 (-)
C3H/HeJ MGP_C3HHeJ_G0017509
protein coding gene Chr10:118154992-118221420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018141
protein coding gene Chr10:123336402-123397224 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015821
protein coding gene Chr10:109211066-109267318 (-)
CAST/EiJ MGP_CASTEiJ_G0017071
protein coding gene Chr10:118431177-118499838 (-)
CBA/J MGP_CBAJ_G0017478
protein coding gene Chr10:128158506-128227862 (-)
DBA/2J MGP_DBA2J_G0017583
protein coding gene Chr10:113749397-113806076 (-)
FVB/NJ MGP_FVBNJ_G0017578
protein coding gene Chr10:112704216-112761579 (-)
LP/J MGP_LPJ_G0017658
protein coding gene Chr10:119775775-119837160 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017607
protein coding gene Chr10:131064537-131126345 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018179
protein coding gene Chr10:117995064-118057264 (-)
PWK/PhJ MGP_PWKPhJ_G0016853
protein coding gene Chr10:113834330-113892631 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016643
protein coding gene Chr10:116802869-116865433 (-)
WSB/EiJ MGP_WSBEiJ_G0017131
protein coding gene Chr10:118174873-118233580 (-)



Homology
more
  • Human Ortholog
    KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNMB4, potassium calcium-activated channel subfamily M regulatory beta subunit 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 27345
    neXtProt AC: NX_Q86W47
    UniProt: Q86W47

  • Chr Location
    12q15; chr12:70366220-70434292 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Kcnmb4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygous mutation of this gene results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 58802 NCBI Gene Model | MGI Sequence Detail 55682 C57BL/6J ±  kb
transcript NM_021452 RefSeq | MGI Sequence Detail 1032 BALB/c  
polypeptide Q9JIN6 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009269 calcium-activated potassium channel subunit beta-4
  • InterPro Domains
    IPR003930 Potassium channel, calcium-activated, BK, beta subunit
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920173
References
more
  • Summaries
    All 50
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:250373 Whitmire LE, et al., Downregulation of KCNMB4 expression and changes in BK channel subtype in hippocampal granule neurons following seizure activity. PLoS One. 2017;12(11):e0188064

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory