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Hs1bp3 Gene Detail
Summary
  • Symbol
    Hs1bp3
  • Name
    HCLS1 binding protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913224
    NCBI Gene: 58240
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:8313433-8343824 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 3.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913224
protein coding gene Chr12:8313432-8343824 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019584
protein coding gene Chr12:5350273-5382326 (+)
A/J MGP_AJ_G0019551
protein coding gene Chr12:5210232-5240612 (+)
AKR/J MGP_AKRJ_G0019521
protein coding gene Chr12:5550080-5582517 (+)
BALB/cJ MGP_BALBcJ_G0019526
protein coding gene Chr12:5288616-5318981 (+)
C3H/HeJ MGP_C3HHeJ_G0019332
protein coding gene Chr12:5333998-5365087 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019975
protein coding gene Chr12:5492058-5522467 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017600
protein coding gene Chr12:5013353-5045255 (+)
CAST/EiJ MGP_CASTEiJ_G0018887
protein coding gene Chr12:5373091-5417199 (+)
CBA/J MGP_CBAJ_G0019303
protein coding gene Chr12:6029492-6062223 (+)
DBA/2J MGP_DBA2J_G0019416
protein coding gene Chr12:5164086-5194910 (+)
FVB/NJ MGP_FVBNJ_G0019407
protein coding gene Chr12:5129690-5160030 (+)
LP/J MGP_LPJ_G0019487
protein coding gene Chr12:5393029-5423349 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019440
protein coding gene Chr12:5841113-5873248 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020014
protein coding gene Chr12:5315562-5346420 (+)
PWK/PhJ MGP_PWKPhJ_G0018653
protein coding gene Chr12:5210890-5241723 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018444
protein coding gene Chr12:5317206-5347441 (+)
WSB/EiJ MGP_WSBEiJ_G0018938
protein coding gene Chr12:5348406-5379800 (+)



Homology
more
  • Human Ortholog
    HS1BP3, HCLS1 binding protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HS1BP3, HCLS1 binding protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ETM2, HS1-BP3
  • Links
    NCBI Gene ID: 64342
    neXtProt AC: NX_Q53T59
    UniProt: Q53T59

  • Chr Location
    2p24.1; chr2:20553861-20651661 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10980
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HS1BP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 58240 NCBI Gene Model | MGI Sequence Detail 30392 C57BL/6J ±  kb
transcript NM_021429 RefSeq | MGI Sequence Detail 2958 C57BL/6  
polypeptide Q3TC93 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 4
References
more
  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:64960 Takemoto Y, et al., Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. Int Immunol. 1999 Dec;11(12):1957-64
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory