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Fhl5 Gene Detail
Summary
  • Symbol
    Fhl5
  • Name
    four and a half LIM domains 5
  • Synonyms
    1700027G07Rik, ACT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913192
    NCBI Gene: 57756
  • Gene Overview
    MyGene.info: FHL5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:25199908-25242876 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 10.58 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913192
protein coding gene Chr4:25199907-25243046 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028102
protein coding gene Chr4:22303696-22345905 (-)
A/J MGP_AJ_G0028060
protein coding gene Chr4:21644372-21701655 (-)
AKR/J MGP_AKRJ_G0028025
protein coding gene Chr4:22140677-22184871 (-)
BALB/cJ MGP_BALBcJ_G0028071
protein coding gene Chr4:21719349-21760804 (-)
C3H/HeJ MGP_C3HHeJ_G0027801
protein coding gene Chr4:22330450-22371180 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028514
protein coding gene Chr4:23276509-23323807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025856
protein coding gene Chr4:20116767-20158164 (-)
CAST/EiJ MGP_CASTEiJ_G0027256
protein coding gene Chr4:22036462-22082836 (-)
CBA/J MGP_CBAJ_G0027774
protein coding gene Chr4:23890516-23934060 (-)
DBA/2J MGP_DBA2J_G0027917
protein coding gene Chr4:21560797-21601821 (-)
FVB/NJ MGP_FVBNJ_G0027883
protein coding gene Chr4:21199335-21240600 (-)
LP/J MGP_LPJ_G0028026
protein coding gene Chr4:22414023-22455462 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027916
protein coding gene Chr4:25402801-25459497 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028573
protein coding gene Chr4:22115781-22158062 (-)
PWK/PhJ MGP_PWKPhJ_G0026976
protein coding gene Chr4:21242524-21286112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026804
protein coding gene Chr4:21876164-21920093 (-)
WSB/EiJ MGP_WSBEiJ_G0027333
protein coding gene Chr4:22057984-22102524 (-)



Homology
more
  • Human Ortholog
    FHL5, four and a half LIM domains 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FHL5, four and a half LIM domains 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    1700027G07Rik, ACT, dJ393D12.2, FHL-5
  • Links
    NCBI Gene ID: 9457
    neXtProt AC: NX_Q5TD97
    UniProt: Q5TD97

  • Chr Location
    6q16.1; chr6:96562525-96618626 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23230
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FHL5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 images
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for disruptions of this gene have reduced sperm counts and abnormal sperm but are none the less fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028259 Ensembl Gene Model | MGI Sequence Detail 42969 C57BL/6J ±  kb
    transcript ENSMUST00000029922 Ensembl | MGI Sequence Detail 1106 Not Applicable  
    polypeptide ENSMUSP00000029922 Ensembl | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917322
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 1
    • Earliest
      J:64956 Fimia GM, et al., CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature. 1999 Mar 11;398(6723):165-9
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory