Fhl5 MGI Mouse Gene Detail - MGI:1913192 - four and a half LIM domains 5

Symbol

Fhl5
Name

four and a half LIM domains 5
Synonyms

1700027G07Rik, ACT

Feature Type

protein coding gene
IDs

MGI:1913192
NCBI Gene: 57756
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr4:25199907-25242852 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 10.58 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

1489 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913192	protein coding gene	Chr4:25199907-25242876 (-)
129S1/SvImJ	ENSMUSG00200012010	protein coding gene	Chr4:21871603-21914558 (-)
A/J	ENSMUSG00195000173	protein coding gene	Chr4:22395271-22438234 (-)
AKR/J	ENSMUSG00220014494	protein coding gene	Chr4:22159587-22202544 (-)
BALB/cJ	ENSMUSG00180000138	protein coding gene	Chr4:21907071-21950033 (-)
C3H/HeJ	ENSMUSG00175002267	protein coding gene	Chr4:22367518-22410484 (-)
C57BL/6NJ	ENSMUSG00215000762	protein coding gene	Chr4:21984936-22027912 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025856	protein coding gene	Chr4:20116767-20158164 (-)
CAST/EiJ	ENSTCUG00005000238	protein coding gene	Chr4:21851609-21895741 (-)
CBA/J	ENSMUSG00210004504	protein coding gene	Chr4:22091655-22134626 (-)
DBA/2J	ENSMUSG00185000316	protein coding gene	Chr4:22183235-22226213 (-)
FVB/NJ	ENSMUSG00205000427	protein coding gene	Chr4:21693057-21736023 (-)
JF1/MsJ	ENSUMUG00000001825	protein coding gene	Chr4:22135412-22179469 (-)
LP/J	ENSMUSG00230000352	protein coding gene	Chr4:25443243-25486193 (-)
NOD/ShiLtJ	ENSMUSG00190000190	protein coding gene	Chr4:22090505-22133452 (-)
NZO/HlLtJ	ENSMUSG00225001867	protein coding gene	Chr4:29388563-29431526 (-)
PWK/PhJ	ENSLUMG00010007507	protein coding gene	Chr4:21549471-21594105 (-)
SPRET/EiJ	ENSMSPG00010002309	protein coding gene	Chr4:22232707-22276508 (-)
WSB/EiJ	ENSIUOG00005004839	protein coding gene	Chr4:21827535-21870522 (-)

Human Ortholog

FHL5, four and a half LIM domains 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FHL5, four and a half LIM domains 5
Synonyms

1700027G07Rik, ACT, dJ393D12.2, FHL-5
Links

HGNC:17371

NCBI Gene ID: 9457

UniProt: Q5TD97
Chr Location

6q16.1; chr6:96562548-96619616 (+) GRCh38

MGI Vertebrate Homology

Fhl5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FHL5
Gene Tree

Fhl5

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
3 images
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for disruptions of this gene have reduced sperm counts and abnormal sperm but are none the less fertile.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

656
Tissues

35
cDNA Data

16
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FHL5

Xenbase fhl5

ZFIN fhl5

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All Sequences

36
RefSeq

6
UniProt

1
CCDS

CCDS18009.1

Ensembl

ENSMUSG00000028259 (Evidence)
NCBI Gene

57756

			Length	Strain/Species	Flank
genomic	57756	NCBI Gene Model \| MGI Sequence Detail	42946	C57BL/6J	± kb
transcript	NM_001379528	RefSeq \| MGI Sequence Detail	1148	C57BL/6
polypeptide	Q9WTX7	UniProt \| EBI \| MGI Sequence Detail	284	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007515 four and a half LIM domains protein 5

(term hierarchy)
InterPro Domains

IPR056807 FHL1/2/3/5, N-terminal LIM domain

IPR042947 FHL5, second LIM domain

IPR001781 Zinc finger, LIM-type

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All nucleic 17

cDNA 16

Other 1

Microarray probesets 2

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MGI:1917322

Summaries

All 36

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 4
Earliest

J:64956 Fimia GM, et al., CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature. 1999 Mar 11;398(6723):165-9
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Fhl5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41103	Chr4:25242833-25242873 (-)	-1 bp
Tssr41102	Chr4:25242825-25242830 (-)	24 bp
Tssr41101	Chr4:25242256-25242271 (-)	588 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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