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Fhl5
Gene Detail
Symbol

Name
ID
Fhl5
four and a half LIM domains 5
MGI:1913192
Synonyms
1700027G07Rik, ACT
Feature Type
protein coding gene
Genetic Map
Chromosome 4
10.58 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:25199908-25242876 bp, - strand
From VEGA annotation of GRCm38

  42969 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: FHL5
Gene Tree: Fhl5

Human
homologs
FHL5, four and a half LIM domains 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9457
neXtProt AC: NX_Q5TD97

Human Synonyms: ACT, dJ393D12.2

Human Chr (Location): 6q16.1-q16.3; chr6:96562548-96618620 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for disruptions of this gene have reduced sperm counts and abnormal sperm but are none the less fertile.
 
Phenotype Images(3)
Interactions
Fhl5 interacts with 15 markers (Mir181d, Mir182, Mir205, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (55)    Tissues (34)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FHL5 ; Xenbase fhl5 ; ZFIN fhl5    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000004835 (Evidence)
Ensembl Gene Model ENSMUSG00000028259 (Evidence)
Entrez Gene 57756 (Evidence)
UniGene 87325
DFCI TC1585999
DoTS DT.60108163
NIA Mouse Gene Index U024895
Consensus CDS Project CCDS18009.1
International Mouse Phenotyping Consortium Status Fhl5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004835 VEGA Gene Model | MGI Sequence Detail 42969 C57BL/6J ±  kb
transcript OTTMUST00000010833 VEGA | MGI Sequence Detail 1106 Not Applicable 
polypeptide OTTMUSP00000005086 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(278 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000007515 four and a half LIM domains protein 5
References
(Earliest) J:64956 Fimia GM, et al., CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature. 1999 Mar 11;398(6723):165-9
(Latest) J:170319 Yabuta Y, et al., TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol. 2011 Mar 7;192(5):781-95
All references(29)
Other
accession IDs
MGI:1917322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory