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Pias3 Gene Detail
Summary
  • Symbol
    Pias3
  • Name
    protein inhibitor of activated STAT 3
  • Synonyms
    Pias3L
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913126
    NCBI Gene: 229615
  • Gene Overview
    MyGene.info: PIAS3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:96696384-96706070 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9687 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.95 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PIAS3, protein inhibitor of activated STAT 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PIAS3, protein inhibitor of activated STAT 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZMIZ5
  • Links
    NCBI Gene ID: 10401
    neXtProt AC: NX_Q9Y6X2
    UniProt: Q9Y6X2

  • Chr Location
    1q21.1; chr1:145848522-145859081 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    12 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Pias3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Double KO mice display a retinal phenotype reduced M-cone response at P21 and reduced S-cone and rod responses from 7 months.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034169 VEGA Gene Model | MGI Sequence Detail 9687 C57BL/6J ±  kb
transcript OTTMUST00000086631 VEGA | MGI Sequence Detail 2931 Not Applicable  
polypeptide OTTMUSP00000046910 VEGA | MGI Sequence Detail 628 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 13
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 68
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 12
    Phenotypes 12
  • Earliest
    J:52872 Chung CD, et al., Specific inhibition of Stat3 signal transduction by PIAS3. Science. 1997 Dec 5;278(5344):1803-5
  • Latest
    J:260447 Usui N, et al., Foxp1 regulation of neonatal vocalizations via cortical development. Genes Dev. 2017 Oct 15;31(20):2039-2055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support.
last database update
06/12/2018
MGI 6.12
The Jackson Laboratory