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Tmem45a Gene Detail
Summary
  • Symbol
    Tmem45a
  • Name
    transmembrane protein 45a
  • Synonyms
    C630002M10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913122
    NCBI Gene: 56277
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:56805161-56886166 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 34.22 cM, cytoband C1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    978 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913122
 protein coding gene Chr16:56805161-56886433 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022892
 protein coding gene Chr16:55947822-56036135 (-)
A/J MGP_AJ_G0022859
 protein coding gene Chr16:53551489-53639375 (-)
AKR/J MGP_AKRJ_G0022831
 protein coding gene Chr16:55236223-55325209 (-)
BALB/cJ MGP_BALBcJ_G0022859
 protein coding gene Chr16:53639487-53729904 (-)
C3H/HeJ MGP_C3HHeJ_G0022622
 protein coding gene Chr16:55429369-55523085 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023307
 protein coding gene Chr16:57524545-57601461 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020818
 protein coding gene Chr16:53216321-53297106 (-)
CAST/EiJ MGP_CASTEiJ_G0022149
 protein coding gene Chr16:55818859-55963371 (-)
CBA/J MGP_CBAJ_G0022595
 protein coding gene Chr16:59825966-59918635 (-)
DBA/2J MGP_DBA2J_G0022727
 protein coding gene Chr16:53294541-53387965 (-)
FVB/NJ MGP_FVBNJ_G0022702
 protein coding gene Chr16:53060012-53140760 (-)
LP/J MGP_LPJ_G0022794
 protein coding gene Chr16:55767953-55853405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022720
 protein coding gene Chr16:60166242-60254142 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023322
 protein coding gene Chr16:55403416-55492895 (-)
PWK/PhJ MGP_PWKPhJ_G0021888
 protein coding gene Chr16:53621343-53704348 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021718
 protein coding gene Chr16:55155715-55243883 (-)
WSB/EiJ MGP_WSBEiJ_G0022193
 protein coding gene Chr16:55429240-55517275 (-)



Homology
more
  • Human Ortholog
    TMEM45A, transmembrane protein 45A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TMEM45A, transmembrane protein 45A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DERP7, DNAPTP4
  • Links
    NCBI Gene ID: 55076
    neXtProt AC: NX_Q9NWC5
    UniProt: Q9NWC5

  • Chr Location
    3q12.2; chr3:100492619-100577453 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for a null allele exhibit epidermal morphogenesis, keratinization and epidermal barrier function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    663
  • Tissues
    27
  • cDNA Data
    31
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022754 Ensembl Gene Model | MGI Sequence Detail 81006 C57BL/6J ±  kb
transcript ENSMUST00000023435 Ensembl | MGI Sequence Detail 2701 Not Applicable  
polypeptide ENSMUSP00000023435 Ensembl | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 31
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:65059 MacLeod CL, et al., Isolation of novel complementary DNA clones from T lymphoma cells: one encodes a putative multiple membrane-spanning protein. Cell Growth Differ. 1990 Jun;1(6):271-9
  • Latest
    J:235703 Hayez A, et al., TMEM45A Is Dispensable for Epidermal Morphogenesis, Keratinization and Barrier Formation. PLoS One. 2016;11(1):e0147069
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2020
MGI 6.15 		The Jackson Laboratory