Tmem45a MGI Mouse Gene Detail - MGI:1913122

Symbol

Tmem45a
Name

transmembrane protein 45a
Synonyms

C630002M10Rik

Feature Type

protein coding gene
IDs

MGI:1913122
NCBI Gene: 56277
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr16:56805161-56886166 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 34.22 cM, cytoband C1.1
Mapping Data

3 experiments

SNPs within 2kb

978 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913122	protein coding gene	Chr16:56805161-56886433 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022892	protein coding gene	Chr16:55947822-56036135 (-)
A/J	MGP_AJ_G0022859	protein coding gene	Chr16:53551489-53639375 (-)
AKR/J	MGP_AKRJ_G0022831	protein coding gene	Chr16:55236223-55325209 (-)
BALB/cJ	MGP_BALBcJ_G0022859	protein coding gene	Chr16:53639487-53729904 (-)
C3H/HeJ	MGP_C3HHeJ_G0022622	protein coding gene	Chr16:55429369-55523085 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023307	protein coding gene	Chr16:57524545-57601461 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020818	protein coding gene	Chr16:53216321-53297106 (-)
CAST/EiJ	MGP_CASTEiJ_G0022149	protein coding gene	Chr16:55818859-55963371 (-)
CBA/J	MGP_CBAJ_G0022595	protein coding gene	Chr16:59825966-59918635 (-)
DBA/2J	MGP_DBA2J_G0022727	protein coding gene	Chr16:53294541-53387965 (-)
FVB/NJ	MGP_FVBNJ_G0022702	protein coding gene	Chr16:53060012-53140760 (-)
LP/J	MGP_LPJ_G0022794	protein coding gene	Chr16:55767953-55853405 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022720	protein coding gene	Chr16:60166242-60254142 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023322	protein coding gene	Chr16:55403416-55492895 (-)
PWK/PhJ	MGP_PWKPhJ_G0021888	protein coding gene	Chr16:53621343-53704348 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021718	protein coding gene	Chr16:55155715-55243883 (-)
WSB/EiJ	MGP_WSBEiJ_G0022193	protein coding gene	Chr16:55429240-55517275 (-)

Human Ortholog

TMEM45A, transmembrane protein 45A

Vertebrate Orthologs

8

Human Ortholog

TMEM45A, transmembrane protein 45A
Orthology source: HomoloGene, HGNC
Synonyms

DERP7, DNAPTP4
Links

HGNC:25480

NCBI Gene ID: 55076

neXtProt AC: NX_Q9NWC5

UniProt: Q9NWC5
Chr Location

3q12.2; chr3:100492619-100577453 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41215
1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: TMEM45A
Gene Tree

Tmem45a

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

1
Gene trapped

15
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit epidermal morphogenesis, keratinization and epidermal barrier function.

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All GO Annotations

3
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

663
Tissues

27
cDNA Data

31
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem45a

ZFIN tmem45a

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Tmem45a interacts with 201 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

52
RefSeq

16
UniProt

4
CCDS

CCDS28226.1
UniGene

262328

Ensembl

ENSMUSG00000022754 (Evidence)
NCBI Gene

56277

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022754	Ensembl Gene Model \| MGI Sequence Detail	81006	C57BL/6J	± kb
transcript	ENSMUST00000023435	Ensembl \| MGI Sequence Detail	2701	Not Applicable
polypeptide	ENSMUSP00000023435	Ensembl \| MGI Sequence Detail	273	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029808 transmembrane protein 45A

(term hierarchy)
InterPro Domains

IPR006904 Protein of unknown function DUF716

IPR042127 Transmembrane protein 45

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All nucleic 32

cDNA 31

Primer pair 1

Microarray probesets 3

Summaries

All 29

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 6
Earliest

J:65059 MacLeod CL, et al., Isolation of novel complementary DNA clones from T lymphoma cells: one encodes a putative multiple membrane-spanning protein. Cell Growth Differ. 1990 Jun;1(6):271-9
Latest

J:235703 Hayez A, et al., TMEM45A Is Dispensable for Epidermal Morphogenesis, Keratinization and Barrier Formation. PLoS One. 2016;11(1):e0147069

TSS for Tmem45a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141577	Chr16:56886131-56886176 (-)	12 bp
Tssr141576	Chr16:56886093-56886125 (-)	57 bp
Tssr141575	Chr16:56886016-56886026 (-)	145 bp
Tssr141574	Chr16:56885978-56885989 (-)	182 bp
Tssr141573	Chr16:56885955-56885968 (-)	204 bp
Tssr141572	Chr16:56885923-56885932 (-)	238 bp
Tssr141569	Chr16:56831878-56831891 (-)	54,281 bp
Tssr141568	Chr16:56831866-56831875 (-)	54,295 bp
Tssr141567	Chr16:56831838-56831861 (-)	54,316 bp
Tssr141566	Chr16:56831830-56831835 (-)	54,333 bp
Tssr141565	Chr16:56831809-56831819 (-)	54,352 bp
Tssr141564	Chr16:56831772-56831790 (-)	54,385 bp
Tssr141563	Chr16:56831760-56831771 (-)	54,400 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/19/2021 MGI 6.16