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Il1rl2 Gene Detail
Summary
  • Symbol
    Il1rl2
  • Name
    interleukin 1 receptor-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913107
    NCBI Gene: 107527
  • Gene Overview
    MyGene.info: IL1RL2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:40324610-40367562 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 18.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    452 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913107
protein coding gene Chr1:40324438-40367562 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015966
protein coding gene Chr1:39110880-39154880 (+)
A/J MGP_AJ_G0015950
protein coding gene Chr1:38005494-38051293 (+)
AKR/J MGP_AKRJ_G0015905
protein coding gene Chr1:38496798-38537465 (+)
BALB/cJ MGP_BALBcJ_G0015904
protein coding gene Chr1:37664451-37708969 (+)
C3H/HeJ MGP_C3HHeJ_G0015737
protein coding gene Chr1:38782638-38832666 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016357
protein coding gene Chr1:40716932-40760767 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014079
protein coding gene Chr1:34938889-34983667 (+)
CAST/EiJ MGP_CASTEiJ_G0015318
protein coding gene Chr1:38686002-38729345 (+)
CBA/J MGP_CBAJ_G0015709
protein coding gene Chr1:41926527-41974461 (+)
DBA/2J MGP_DBA2J_G0015810
protein coding gene Chr1:37282883-37328723 (+)
FVB/NJ MGP_FVBNJ_G0015812
protein coding gene Chr1:36834532-36876931 (+)
LP/J MGP_LPJ_G0015880
protein coding gene Chr1:39445302-39489650 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015832
protein coding gene Chr1:43930778-43974564 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016404
protein coding gene Chr1:38644710-38686007 (+)
PWK/PhJ MGP_PWKPhJ_G0015101
protein coding gene Chr1:37104836-37146224 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014883
protein coding gene Chr1:38583478-38649538 (+)
WSB/EiJ MGP_WSBEiJ_G0015380
protein coding gene Chr1:38615391-38655071 (+)



Homology
more
  • Human Ortholog
    IL1RL2, interleukin 1 receptor like 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL1RL2, interleukin 1 receptor like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-1Rrp2, IL1R-rp2, IL1RRP2, IL-36R
  • Links
    NCBI Gene ID: 8808
    neXtProt AC: NX_Q9HB29
    UniProt: Q9HB29

  • Chr Location
    2q12.1; chr2:102186973-102242906 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele are viable and overtly normal and have normal skin in an unchallenged context.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070942 Ensembl Gene Model | MGI Sequence Detail 42953 C57BL/6J ±  kb
transcript ENSMUST00000095020 Ensembl | MGI Sequence Detail 1950 Not Applicable  
polypeptide ENSMUSP00000092630 Ensembl | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 4
Other
Accession IDs
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MGI:2138277, MGI:2138611
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:64721 Born TL, et al., Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. DELINEATION OF A NEW CLASS OF IL-1R-RELATED PROTEINS BASED ON SIGNALING. J Biol Chem. 2000 Sep 29;275(39):29946-54
  • Latest
    J:263562 Ngo VL, et al., A cytokine network involving IL-36gamma, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5076-E5085

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory