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Il1rl2 Gene Detail
Summary
  • Symbol
    Il1rl2
  • Name
    interleukin 1 receptor-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913107
    NCBI Gene: 107527
  • Gene Overview
    MyGene.info: IL1RL2
Location & Maps
more
  • Sequence Map
    Chr1:40324610-40367562 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42953 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 18.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IL1RL2, interleukin 1 receptor like 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL1RL2, interleukin 1 receptor like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IL-1Rrp2, IL1R-rp2, IL1RRP2, IL-36R
  • Links
    NCBI Gene ID: 8808
    neXtProt AC: NX_Q9HB29

  • Chr Location
    2q12; chr2:102186157-102240002 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Il1rl2
  • Incidental Mutations
Mice homozygous for a reporter allele are viable and overtly normal and have normal skin in an unchallenged context.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050520 VEGA Gene Model | MGI Sequence Detail 42953 C57BL/6J ±  kb
transcript OTTMUST00000128136 VEGA | MGI Sequence Detail 1950 Not Applicable  
polypeptide OTTMUSP00000068977 VEGA | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    452 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 34
    cDNA 34

    Microarray probesets 4
Other
Accession IDs
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MGI:2138277, MGI:2138611
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:64721 Born TL, et al., Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. DELINEATION OF A NEW CLASS OF IL-1R-RELATED PROTEINS BASED ON SIGNALING. J Biol Chem. 2000 Sep 29;275(39):29946-54
  • Latest
    J:225959 Wang X, et al., IL-36gamma Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses. Cancer Cell. 2015 Sep 14;28(3):296-306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory