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Cldn10 Gene Detail
Summary
  • Symbol
    Cldn10
  • Name
    claudin 10
  • Synonyms
    6720456I16Rik, Cldn10a, Cldn10b, D14Ertd728e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913101
    NCBI Gene: 58187
  • Gene Overview
    MyGene.info: CLDN10
Location & Maps
more
  • Sequence Map
    Chr14:118787908-118875489 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      87582 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 62.55 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CLDN10, claudin 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLDN10, claudin 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPETRL3, OSPL, OSP-L
  • Links
    NCBI Gene ID: 9071
    neXtProt AC: NX_P78369
    UniProt: P78369

  • Chr Location
    13q32.1; chr13:95433588-95579756 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 5076
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLDN10
  • Gene Tree
    Cldn10
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking expression of this gene in the thick ascending limb of renal tubules display nephrocalcinosis, hypermagnesemia, and abnormalities in renal reabsorbtion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    115
  • Tissues
    54
  • cDNA Data
    11
  • Literature Summary
    14
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023307 VEGA Gene Model | MGI Sequence Detail 87582 C57BL/6J ±  kb
transcript OTTMUST00000056452 VEGA | MGI Sequence Detail 2128 Not Applicable  
polypeptide OTTMUSP00000027131 VEGA | MGI Sequence Detail 231 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    561 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    cDNA 12
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGI:1289167, MGI:1925138, MGI:3696570
References
more
  • Summaries
    All 46
    Developmental Gene Expression 14
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:64941 Morita K, et al., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol. 1999 May 3;145(3):579-88
  • Latest
    J:239545 Milatz S, et al., Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E219-E227
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory