Cldn10 MGI Mouse Gene Detail - MGI:1913101

Cldn10 Gene Detail

Symbol

Cldn10
Name

claudin 10
Synonyms

6720456I16Rik, Cldn10a, Cldn10b, D14Ertd728e

Feature Type

protein coding gene
IDs

MGI:1913101
NCBI Gene: 58187
Gene Overview

MyGene.info: CLDN10

Sequence Map

Chr14:118787908-118875489 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

87582 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 62.55 cM
Mapping Data

4 experiments

Human Ortholog

CLDN10, claudin 10

Vertebrate Orthologs

10

Human Ortholog

CLDN10, claudin 10
Orthology source: HomoloGene, HGNC
Synonyms

CPETRL3, OSP-L
Links

HGNC:2033

NCBI Gene ID: 9071

neXtProt AC: NX_P78369
Chr Location

13q31-q34; chr13:95433599-95579756 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 5076
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: CLDN10
Gene Tree

Cldn10

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
1 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Cldn10
Incidental Mutations

Mutagenetix , APF

Mice lacking expression of this gene in the thick ascending limb of renal tubules display nephrocalcinosis, hypermagnesemia, and abnormalities in renal reabsorbtion.

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All GO Annotations

11
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

115
Tissues

54
cDNA Data

11
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

ZFIN cldn10b

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Cldn10 interacts with 184 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

40
RefSeq

12
UniProt

2
CCDS

CCDS37009.1, CCDS37010.1, CCDS49566.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023307	VEGA Gene Model \| MGI Sequence Detail	87582	C57BL/6J	± kb
transcript	OTTMUST00000056452	VEGA \| MGI Sequence Detail	2128	Not Applicable
polypeptide	OTTMUSP00000027131	VEGA \| MGI Sequence Detail	231	Not Applicable

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SNPs within 2kb

561 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000005538 claudin-10
InterPro Domains

IPR006187 Claudin

IPR003554 Claudin-10

IPR017974 Claudin, conserved site

IPR004031 PMP-22/EMP/MP20/Claudin superfamily

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All nucleic 15

cDNA 12

Primer pair 3

Microarray probesets 3

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MGI:1289167, MGI:1925138, MGI:3696570

Summaries

All 41

Developmental Gene Expression 14

Gene Ontology 4

Phenotypes 6
Earliest

J:64941 Morita K, et al., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol. 1999 May 3;145(3):579-88
Latest

J:188580 Breiderhoff T, et al., Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14241-6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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