Cldn10 MGI Mouse Gene Detail - MGI:1913101

Symbol

Cldn10
Name

claudin 10
Synonyms

6720456I16Rik, Cldn10a, Cldn10b, D14Ertd728e

Feature Type

protein coding gene
IDs

MGI:1913101
NCBI Gene: 58187
Gene Overview

MyGene.info: CLDN10
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:118787871-118874525 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 62.55 cM
Mapping Data

4 experiments

SNPs within 2kb

555 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913101	protein coding gene	Chr14:118787871-118875489 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0021651	protein coding gene	Chr14:116400899-116492190 (+)
A/J	MGP_AJ_G0021611	protein coding gene	Chr14:111957772-112043261 (+)
AKR/J	MGP_AKRJ_G0021587	protein coding gene	Chr14:115578693-115668112 (+)
BALB/cJ	MGP_BALBcJ_G0021617	protein coding gene	Chr14:112498216-112586166 (+)
C3H/HeJ	MGP_C3HHeJ_G0021395	protein coding gene	Chr14:115474397-115565631 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022057	protein coding gene	Chr14:120918099-121012650 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019595	protein coding gene	Chr14:107991193-108077554 (+)
CAST/EiJ	MGP_CASTEiJ_G0020910	protein coding gene	Chr14:113309680-113427036 (+)
CBA/J	MGP_CBAJ_G0021363	protein coding gene	Chr14:125539429-125632536 (+)
DBA/2J	MGP_DBA2J_G0021486	protein coding gene	Chr14:111870807-111957794 (+)
FVB/NJ	MGP_FVBNJ_G0021464	protein coding gene	Chr14:110194200-110282100 (+)
LP/J	MGP_LPJ_G0021554	protein coding gene	Chr14:117431395-117527100 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021491	protein coding gene	Chr14:130600634-130707170 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022080	protein coding gene	Chr14:115062399-115157390 (+)
PWK/PhJ	MGP_PWKPhJ_G0020654	protein coding gene	Chr14:108881439-108972974 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020492	protein coding gene	Chr14:111309915-111405344 (+)
WSB/EiJ	MGP_WSBEiJ_G0020966	protein coding gene	Chr14:115844310-115938586 (+)

Human Ortholog

CLDN10, claudin 10

Vertebrate Orthologs

10

Human Ortholog

CLDN10, claudin 10
Orthology source: HomoloGene, HGNC
Synonyms

CPETRL3, HELIX, OSPL, OSP-L
Links

HGNC:2033

NCBI Gene ID: 9071

neXtProt AC: NX_P78369

UniProt: P78369
Chr Location

13q32.1; chr13:95433588-95579756 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5076
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CLDN10
Gene Tree

Cldn10

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
1 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Cldn10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice lacking expression of this gene in the thick ascending limb of renal tubules display nephrocalcinosis, hypermagnesemia, and abnormalities in renal reabsorbtion.

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All GO Annotations

13
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

115
Tissues

54
cDNA Data

12
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cldn10b

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Cldn10 interacts with 184 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

51
RefSeq

12
UniProt

2
CCDS

CCDS37009.1, CCDS37010.1, CCDS49566.1

Ensembl

ENSMUSG00000022132 (Evidence)
NCBI Gene

58187

			Length	Strain/Species	Flank
genomic	58187	NCBI Gene Model \| MGI Sequence Detail	86655	C57BL/6J	± kb
transcript	NM_023878	RefSeq \| MGI Sequence Detail	1200	C57BL/6
polypeptide	Q9Z0S6	UniProt \| EBI \| MGI Sequence Detail	231	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005538 claudin-10

(term hierarchy)
InterPro Domains

IPR006187 Claudin

IPR003554 Claudin-10

IPR017974 Claudin, conserved site

IPR004031 PMP-22/EMP/MP20/Claudin superfamily

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All nucleic 16

cDNA 13

Primer pair 3

Microarray probesets 3

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MGI:1289167, MGI:1925138, MGI:3696570

Summaries

All 49

Developmental Gene Expression 14

Gene Ontology 6

Phenotypes 7
Earliest

J:64941 Morita K, et al., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol. 1999 May 3;145(3):579-88
Latest

J:252627 Perez EC, et al., The axis IL-10/claudin-10 is implicated in the modulation of aggressiveness of melanoma cells by B-1 lymphocytes. PLoS One. 2017;12(11):e0187333

TSS for Cldn10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127171	Chr14:118787894-118787942 (+)	47 bp
Tssr127172	Chr14:118787946-118787951 (+)	78 bp
Tssr4527	Chr14:118787959-118787962 (+)	90 bp
Tssr127173	Chr14:118854695-118854700 (+)	66,827 bp
Tssr127174	Chr14:118854955-118854976 (+)	67,095 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/06/2018 MGI 6.13