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Sh3rf1 Gene Detail
Summary
  • Symbol
    Sh3rf1
  • Name
    SH3 domain containing ring finger 1
  • Synonyms
    2200003J05Rik, Posh, Sh3md2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913066
    NCBI Gene: 59009
  • Gene Overview
    MyGene.info: SH3RF1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:61223872-61396071 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 30.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1530 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913066
protein coding gene Chr8:61223872-61464778 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033634
protein coding gene Chr8:61132768-61315412 (+)
A/J MGP_AJ_G0033616
protein coding gene Chr8:58521102-58692196 (+)
AKR/J MGP_AKRJ_G0033541
protein coding gene Chr8:60205000-60389895 (+)
BALB/cJ MGP_BALBcJ_G0033612
protein coding gene Chr8:58775773-58951502 (+)
C3H/HeJ MGP_C3HHeJ_G0033322
protein coding gene Chr8:60874142-61057302 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034129
protein coding gene Chr8:63460387-63653782 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031077
protein coding gene Chr8:53770273-53938253 (+)
CAST/EiJ MGP_CASTEiJ_G0032647
protein coding gene Chr8:60288991-60461283 (+)
CBA/J MGP_CBAJ_G0033300
protein coding gene Chr8:65750040-65952736 (+)
DBA/2J MGP_DBA2J_G0033454
protein coding gene Chr8:58274728-58448598 (+)
FVB/NJ MGP_FVBNJ_G0033395
protein coding gene Chr8:57582965-57753974 (+)
LP/J MGP_LPJ_G0033542
protein coding gene Chr8:61097365-61276987 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033439
protein coding gene Chr8:67864536-68052297 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034147
protein coding gene Chr8:60461417-60642972 (+)
PWK/PhJ MGP_PWKPhJ_G0032356
protein coding gene Chr8:57583183-57754263 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032192
protein coding gene Chr8:59440577-59610299 (+)
WSB/EiJ MGP_WSBEiJ_G0032764
protein coding gene Chr8:60785602-60969893 (+)



Homology
more
  • Human Ortholog
    SH3RF1, SH3 domain containing ring finger 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SH3RF1, SH3 domain containing ring finger 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    POSH, RNF142, SH3MD2
  • Links
    NCBI Gene ID: 57630
    neXtProt AC: NX_Q7Z6J0
    UniProt: Q7Z6J0

  • Chr Location
    4q32.3-q33; chr4:169094256-169271098 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10988
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SH3RF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031642 Ensembl Gene Model | MGI Sequence Detail 172200 C57BL/6J ±  kb
    transcript ENSMUST00000034060 Ensembl | MGI Sequence Detail 5479 Not Applicable  
    polypeptide ENSMUSP00000034060 Ensembl | MGI Sequence Detail 891 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 62

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916398, MGI:2142899
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:64936 Tapon N, et al., A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J. 1998 Mar 2;17(5):1395-404
    • Latest
      J:260508 West RJH, et al., The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia. Hum Mol Genet. 2018 Apr 15;27(8):1382-1395

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory