Ywhab
Gene Detail

Symbol Name ID

Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide MGI:1891917

Synonyms

1300003C17Rik, 14-3-3 beta

Feature Type

protein coding gene

Genetic Map

Chromosome 2

84.59 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:163994960-164018588 bp, + strand From VEGA annotation of GRCm38   23629 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhab

Human homologs

Human Homolog		YWHAB, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
NCBI Gene ID		7529
neXtProt AC		NX_P31946
Human Synonyms		GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Human Chr (Location)		20q13.1; chr20:44885599-44908532 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(32) : Gene trapped(31) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Ywhab interacts with 332 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	cytoplasmic sequestering of protein, negative regulation of protein dephosphorylation, ...
Component	cell, cytoplasm, ...
Function	enzyme binding, histone deacetylase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (160)    Tissues (45)    Images (54)
Theiler Stages: 17, 20, 23, 24, 26, 28

Assay Type	Results
RNA in situ	160

cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016138 (Evidence)
Ensembl Gene Model	ENSMUSG00000018326 (Evidence)
Entrez Gene	54401 (Evidence)
DFCI	TC1573876, TC1647739, TC1764019
DoTS	DT.101233150, DT.101316539, DT.496574, DT.94373085
NIA Mouse Gene Index	U002794
PDB	4GNT
Consensus CDS Project	CCDS17019.1
International Mouse Knockout Project Status	Ywhab

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016138	VEGA Gene Model | MGI Sequence Detail	23629	C57BL/6J
transcript	OTTMUST00000038595	VEGA | MGI Sequence Detail	3013	Not Applicable
polypeptide	OTTMUSP00000017275	VEGA | MGI Sequence Detail	246	Not Applicable

All sequences(76) RefSeq(4) UniProt(3)

Polymorphisms

SNPs within 2kb(125 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR023410	14-3-3 domain
InterPro	IPR000308	14-3-3 protein
InterPro	IPR023409	14-3-3 protein, conserved site
Protein Ontology	PR:000002175	14-3-3 protein beta/alpha protein

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203495 Neukamm SS, et al., Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation. J Biol Chem. 2013 Jun 7;288(23):16403-15
All references(56)

Other accession IDs

MGI:1914136