Ywhab MGI Mouse Gene Detail - MGI:1891917 - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Symbol

Ywhab
Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Synonyms

1300003C17Rik, 14-3-3b, 14-3-3 beta

Feature Type

protein coding gene
IDs

MGI:1891917
NCBI Gene: 54401
Gene Overview

MyGene.info: YWHAB
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:163995197-164018588 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 84.59 cM, cytoband H3
Mapping Data

2 experiments

SNPs within 2kb

122 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891917	protein coding gene	Chr2:163994960-164018588 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026833	protein coding gene	Chr2:169363740-169387182 (+)
A/J	MGP_AJ_G0026799	protein coding gene	Chr2:162517479-162540918 (+)
AKR/J	MGP_AKRJ_G0026770	protein coding gene	Chr2:167325679-167357875 (+)
BALB/cJ	MGP_BALBcJ_G0026808	protein coding gene	Chr2:162858501-162882629 (+)
C3H/HeJ	MGP_C3HHeJ_G0026550	protein coding gene	Chr2:167676621-167701783 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027256	protein coding gene	Chr2:174302374-174326117 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024626	protein coding gene	Chr2:155821018-155844624 (+)
CAST/EiJ	MGP_CASTEiJ_G0026011	protein coding gene	Chr2:168094184-168117612 (+)
CBA/J	MGP_CBAJ_G0026527	protein coding gene	Chr2:180578321-180603450 (+)
DBA/2J	MGP_DBA2J_G0026665	protein coding gene	Chr2:161686898-161710869 (+)
FVB/NJ	MGP_FVBNJ_G0026631	protein coding gene	Chr2:160062840-160086519 (+)
LP/J	MGP_LPJ_G0026768	protein coding gene	Chr2:169475165-169498710 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026653	protein coding gene	Chr2:184245383-184269583 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027312	protein coding gene	Chr2:167226148-167250406 (+)
PWK/PhJ	MGP_PWKPhJ_G0025745	protein coding gene	Chr2:161260743-161281951 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025548	protein coding gene	Chr2:166107621-166132524 (+)
WSB/EiJ	MGP_WSBEiJ_G0026081	protein coding gene	Chr2:168086969-168115353 (+)

Human Ortholog

YWHAB, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

Vertebrate Orthologs

11

Human Ortholog

YWHAB, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Orthology source: HomoloGene, HGNC
Synonyms

GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Links

HGNC:12849

NCBI Gene ID: 7529

neXtProt AC: NX_P31946

UniProt: P31946
Chr Location

20q13.12; chr20:44885599-44908532 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20724
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: YWHAB
Protein SuperFamily

14-3-3 protein
Gene Tree

Ywhab

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Gene trapped

31
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

29
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

58
cDNA Data

19
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ywhab

ZFIN ywhaba, ywhabb

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Ywhab interacts with 331 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

82
RefSeq

4
UniProt

3
CCDS

CCDS17019.1

Ensembl

ENSMUSG00000018326 (Evidence)
NCBI Gene

54401

			Length	Strain/Species	Flank
genomic	54401	NCBI Gene Model \| MGI Sequence Detail	23392	C57BL/6J	± kb
transcript	NM_018753	RefSeq \| MGI Sequence Detail	2775	C57BL/6
polypeptide	Q9CQV8	UniProt \| EBI \| MGI Sequence Detail	246	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000002175 14-3-3 protein beta/alpha

(term hierarchy)
PDB

4GNT, 5F74, 5WFU, 5WFX
InterPro Domains

IPR023410 14-3-3 domain

IPR036815 14-3-3 domain superfamily

IPR000308 14-3-3 protein

IPR023409 14-3-3 protein, conserved site

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All nucleic 24

cDNA 21

Primer pair 2

Other 1

Microarray probesets 7

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MGI:1914136

Summaries

All 66

Developmental Gene Expression 9

Gene Ontology 13

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:277876 Lee JH, et al., Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes. Acta Neuropathol Commun. 2019 May 2;7(1):68

TSS for Ywhab:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21496	Chr2:163995138-163995149 (+)	-53 bp
Tssr21497	Chr2:163995150-163995229 (+)	-7 bp
Tssr21498	Chr2:163995235-163995246 (+)	44 bp
Tssr21499	Chr2:163995271-163995282 (+)	80 bp
Tssr21502	Chr2:164017471-164017485 (+)	22,281 bp
Tssr21503	Chr2:164017587-164017604 (+)	22,399 bp
Tssr21504	Chr2:164017666-164017684 (+)	22,478 bp
Tssr21505	Chr2:164017938-164018028 (+)	22,786 bp
Tssr21506	Chr2:164018075-164018089 (+)	22,885 bp
Tssr21507	Chr2:164018094-164018128 (+)	22,914 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16