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Ywhab Gene Detail
Summary
  • Symbol
    Ywhab
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
  • Synonyms
    1300003C17Rik, 14-3-3b, 14-3-3 beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891917
    NCBI Gene: 54401
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163837082-163860508 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.59 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1060 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891917
 protein coding gene Chr2:163836880-163860508 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026833
 protein coding gene Chr2:169363740-169387182 (+)
A/J MGP_AJ_G0026799
 protein coding gene Chr2:162517479-162540918 (+)
AKR/J MGP_AKRJ_G0026770
 protein coding gene Chr2:167325679-167357875 (+)
BALB/cJ MGP_BALBcJ_G0026808
 protein coding gene Chr2:162858501-162882629 (+)
C3H/HeJ MGP_C3HHeJ_G0026550
 protein coding gene Chr2:167676621-167701783 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027256
 protein coding gene Chr2:174302374-174326117 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024626
 protein coding gene Chr2:155821018-155844624 (+)
CAST/EiJ MGP_CASTEiJ_G0026011
 protein coding gene Chr2:168094184-168117612 (+)
CBA/J MGP_CBAJ_G0026527
 protein coding gene Chr2:180578321-180603450 (+)
DBA/2J MGP_DBA2J_G0026665
 protein coding gene Chr2:161686898-161710869 (+)
FVB/NJ MGP_FVBNJ_G0026631
 protein coding gene Chr2:160062840-160086519 (+)
LP/J MGP_LPJ_G0026768
 protein coding gene Chr2:169475165-169498710 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026653
 protein coding gene Chr2:184245383-184269583 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027312
 protein coding gene Chr2:167226148-167250406 (+)
PWK/PhJ MGP_PWKPhJ_G0025745
 protein coding gene Chr2:161260743-161281951 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025548
 protein coding gene Chr2:166107621-166132524 (+)
WSB/EiJ MGP_WSBEiJ_G0026081
 protein coding gene Chr2:168086969-168115353 (+)



Homology
more
  • Human Ortholog
    YWHAB, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YWHAB, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  • Synonyms
    GW128, HEL-S-1, HS1, KCIP-1, YWHAA
  • Links
    NCBI Gene ID: 7529
    UniProt: P31946

  • Chr Location
    20q13.12; chr20:44885702-44908532 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in hepatocytes exhibit decreased liver glycogen levels, impaired glucose tolerance after pyruvate injection, and enhanced gluconeogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    63
  • cDNA Data
    19
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54401 NCBI Gene Model | MGI Sequence Detail 23427 C57BL/6J ±  kb
    transcript NR_184744 RefSeq | MGI Sequence Detail 3034 C57BL/6  
    polypeptide Q9CQV8 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 21
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914136
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 11
      Gene Ontology 18
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory