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Ywhab Gene Detail
Summary
  • Symbol
    Ywhab
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
  • Synonyms
    1300003C17Rik, 14-3-3b, 14-3-3 beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891917
    NCBI Gene: 54401
  • Gene Overview
    MyGene.info: YWHAB
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163995197-164018588 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.59 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891917
 protein coding gene Chr2:163994960-164018588 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026833
 protein coding gene Chr2:169363740-169387182 (+)
A/J MGP_AJ_G0026799
 protein coding gene Chr2:162517479-162540918 (+)
AKR/J MGP_AKRJ_G0026770
 protein coding gene Chr2:167325679-167357875 (+)
BALB/cJ MGP_BALBcJ_G0026808
 protein coding gene Chr2:162858501-162882629 (+)
C3H/HeJ MGP_C3HHeJ_G0026550
 protein coding gene Chr2:167676621-167701783 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027256
 protein coding gene Chr2:174302374-174326117 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024626
 protein coding gene Chr2:155821018-155844624 (+)
CAST/EiJ MGP_CASTEiJ_G0026011
 protein coding gene Chr2:168094184-168117612 (+)
CBA/J MGP_CBAJ_G0026527
 protein coding gene Chr2:180578321-180603450 (+)
DBA/2J MGP_DBA2J_G0026665
 protein coding gene Chr2:161686898-161710869 (+)
FVB/NJ MGP_FVBNJ_G0026631
 protein coding gene Chr2:160062840-160086519 (+)
LP/J MGP_LPJ_G0026768
 protein coding gene Chr2:169475165-169498710 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026653
 protein coding gene Chr2:184245383-184269583 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027312
 protein coding gene Chr2:167226148-167250406 (+)
PWK/PhJ MGP_PWKPhJ_G0025745
 protein coding gene Chr2:161260743-161281951 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025548
 protein coding gene Chr2:166107621-166132524 (+)
WSB/EiJ MGP_WSBEiJ_G0026081
 protein coding gene Chr2:168086969-168115353 (+)



Homology
more
  • Human Ortholog
    YWHAB, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    YWHAB, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GW128, HEL-S-1, HS1, KCIP-1, YWHAA
  • Links
    NCBI Gene ID: 7529
    neXtProt AC: NX_P31946
    UniProt: P31946

  • Chr Location
    20q13.12; chr20:44885599-44908532 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    58
  • cDNA Data
    19
  • Literature Summary
    9
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54401 NCBI Gene Model | MGI Sequence Detail 23392 C57BL/6J ±  kb
transcript NM_018753 RefSeq | MGI Sequence Detail 2775 C57BL/6  
polypeptide Q9CQV8 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 21
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1914136
References
more
  • Summaries
    All 65
    Developmental Gene Expression 9
    Gene Ontology 13
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:277876 Lee JH, et al., Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes. Acta Neuropathol Commun. 2019 May 2;7(1):68
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2020
MGI 6.15 		The Jackson Laboratory