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Ywhab
Gene Detail
 Symbol
Name
ID
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
MGI:1891917
Synonyms 1300003C17Rik, 14-3-3 beta
Feature Type protein coding gene
Genetic Map
Chromosome 2
84.59 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:163994960-164018588 bp, + strand
From VEGA annotation of GRCm38

  23629 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhab

Human
homologs
Human Homolog YWHAB, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
NCBI Gene ID 7529
neXtProt AC  NX_P31946
Human Synonyms  GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Human Chr (Location)  20q13.1; chr20:44885599-44908532 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(31) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ywhab interacts with 332 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cytoplasmic sequestering of protein, negative regulation of protein dephosphorylation, ...
Component cell, cytoplasm, ...
Function enzyme binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (160)    Tissues (45)    Images (54)
Theiler Stages: 17, 20, 23, 24, 26, 28
Assay TypeResults
RNA in situ 160
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016138 (Evidence)
Ensembl Gene ModelENSMUSG00000018326 (Evidence)
Entrez Gene54401 (Evidence)
DFCITC1573876, TC1647739, TC1764019
DoTSDT.101233150, DT.101316539, DT.496574, DT.94373085
NIA Mouse Gene IndexU002794
PDB4GNT
Consensus CDS ProjectCCDS17019.1
International Mouse Knockout Project StatusYwhab
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016138 VEGA Gene Model | MGI Sequence Detail 23629 C57BL/6J ±  kb
transcript OTTMUST00000038595 VEGA | MGI Sequence Detail 3013 Not Applicable 
polypeptide OTTMUSP00000017275 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000002175 14-3-3 protein beta/alpha protein
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203495 Neukamm SS, et al., Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation. J Biol Chem. 2013 Jun 7;288(23):16403-15
All references(56)
Other
accession IDs
MGI:1914136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory