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Foxo4
Gene Detail
Symbol

Name
ID
Foxo4
forkhead box O4
MGI:1891915
Synonyms
afx, Afxh, Foxo4, Mllt7
Feature Type
protein coding gene
Genetic Map
Chromosome X
43.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:101254528-101260873 bp, + strand
From VEGA annotation of GRCm38

  6346 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4342  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXO4
Protein SuperFamily: forkhead box O protein
Gene Tree: Foxo4

Human
homologs
FOXO4, forkhead box O4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4303
neXtProt AC: NX_P98177

Human Synonyms: AFX, AFX1, MLLT7

Human Chr (Location): Xq13.1; chrX:71096149-71103534 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice hemizygous and homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable histological abnormalities in most tissues.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Foxo4 interacts with 265 markers (Mir1b, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process anatomical structure morphogenesis, cell cycle, ...
Component cytoplasm, cytosol, ...
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (79)    Tissues (78)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
RT-PCR 2
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase foxo4    NEW 
Molecular
reagents
All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000018205 (Evidence)
Ensembl Gene Model ENSMUSG00000042903 (Evidence)
Entrez Gene 54601 (Evidence)
UniGene 240299
DFCI TC1587515, TC1635147, TC1592200
DoTS DT.87047865, DT.488004, DT.101362512
NIA Mouse Gene Index U020062
Consensus CDS Project CCDS41077.1
International Mouse Phenotyping Consortium Status Foxo4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018205 VEGA Gene Model | MGI Sequence Detail 6346 C57BL/6J ±  kb
transcript OTTMUST00000043949 VEGA | MGI Sequence Detail 3162 Not Applicable 
polypeptide OTTMUSP00000019735 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007642 forkhead box protein O4
References
(Earliest) J:63676 Furuyama T, et al., Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J. 2000 Jul 15;349(Pt 2):629-34
(Latest) J:215526 Kim-Muller JY, et al., Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice. Cell Metab. 2014 Oct 7;20(4):593-602
All references(84)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory