About   Help   FAQ
Foxo4
Gene Detail
 Symbol
Name
ID
Foxo4
forkhead box O4
MGI:1891915
Synonyms afx, Afxh, Foxo4, Mllt7
Feature Type protein coding gene
Genetic Map
Chromosome X
43.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:101254528-101260873 bp, + strand
From VEGA annotation of GRCm38

  6346 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4342  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: forkhead box O protein
Gene Tree: Foxo4

Human
homologs
Human Homolog FOXO4, forkhead box O4
NCBI Gene ID 4303
neXtProt AC  NX_P98177
Human Synonyms  AFX, AFX1, MLLT7
Human Chr (Location)  Xq13.1; chrX:71096149-71103534 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice hemizygous and homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable histological abnormalities in most tissues.
 
Interactions
Foxo4 interacts with 265 markers (Mir1b, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cell cycle, cell cycle arrest, ...
Component cytoplasm, cytosol, ...
Function DNA binding, DNA binding, bending, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (79)    Tissues (78)    Images (13)
Theiler Stages: 17, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 77
RT-PCR 2
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) cDNA(36) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018205 (Evidence)
Ensembl Gene ModelENSMUSG00000042903 (Evidence)
Entrez Gene54601 (Evidence)
UniGene240299
DFCITC1587515, TC1592200, TC1635147
DoTSDT.101362512, DT.488004, DT.87047865
NIA Mouse Gene IndexU020062
Consensus CDS ProjectCCDS41077.1
International Mouse Knockout Project StatusFoxo4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018205 VEGA Gene Model | MGI Sequence Detail 6346 C57BL/6J ±  kb
transcript OTTMUST00000043949 VEGA | MGI Sequence Detail 3162 Not Applicable 
polypeptide OTTMUSP00000019735 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007642 forkhead box protein O4
References (Earliest) J:63676 Furuyama T, et al., Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J. 2000 Jul 15;349(Pt 2):629-34
(Latest) J:208828 Bartell SM, et al., FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun. 2014;5:3773
All references(82)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory