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Foxo4 Gene Detail
Summary
  • Symbol
    Foxo4
  • Name
    forkhead box O4
  • Synonyms
    afx, Afxh, Foxo4, Mllt7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891915
    NCBI Gene: 54601
  • Gene Overview
    MyGene.info: FOXO4
Location & Maps
more
  • Sequence Map
    ChrX:101254528-101260873 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6346 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FOXO4, forkhead box O4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOXO4, forkhead box O4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AFX, AFX1, MLLT7
  • Links
    NCBI Gene ID: 4303
    neXtProt AC: NX_P98177

  • Chr Location
    Xq13.1; chrX:71096149-71103534 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotypes from multigenic genotypes
    35 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
Mice hemizygous and homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable histological abnormalities in most tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018205 VEGA Gene Model | MGI Sequence Detail 6346 C57BL/6J ±  kb
transcript OTTMUST00000043949 VEGA | MGI Sequence Detail 3162 Not Applicable  
polypeptide OTTMUSP00000019735 VEGA | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007642 forkhead box protein O4
  • InterPro Domains
    IPR001766 Fork head domain
    IPR030456 Fork head domain conserved site 2
    IPR032068 FOXO protein, KIX-binding domain
    IPR032067 FOXO protein, transactivation domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 39
    cDNA 37
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 85
    Developmental Gene Expression 19
    Diseases 1
    Gene Ontology 8
    Phenotypes 35
  • Earliest
    J:63676 Furuyama T, et al., Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J. 2000 Jul 15;349(Pt 2):629-34
  • Latest
    J:223803 Kuscu N, et al., FOXO1, FOXO3, AND FOXO4 are differently expressed during mouse oocyte maturation and preimplantation embryo development. Gene Expr Patterns. 2015 May-Jul;18(1-2):16-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory