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Cpb2 Gene Detail
Summary
  • Symbol
    Cpb2
  • Name
    carboxypeptidase B2
  • Synonyms
    1110032P04Rik, 4930405E17Rik, carboxypeptidase R, carboxypeptidase U, CPR, CPU, TAFI, thrombin-activatable fibrinolysis inhibitor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891837
    NCBI Gene: 56373
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:75479727-75520995 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 39.73 cM, cytoband D2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891837
protein coding gene Chr14:75479727-75520995 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021568
protein coding gene Chr14:70058712-70104670 (+)
A/J MGP_AJ_G0021526
protein coding gene Chr14:68495610-68539760 (+)
AKR/J MGP_AKRJ_G0021503
protein coding gene Chr14:70527444-70576449 (+)
BALB/cJ MGP_BALBcJ_G0021533
protein coding gene Chr14:68296200-68341964 (+)
C3H/HeJ MGP_C3HHeJ_G0021310
protein coding gene Chr14:70260357-70304805 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021973
protein coding gene Chr14:73128975-73176194 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019511
protein coding gene Chr14:66138553-66179222 (+)
CAST/EiJ MGP_CASTEiJ_G0020827
protein coding gene Chr14:66926025-66970401 (+)
CBA/J MGP_CBAJ_G0021278
protein coding gene Chr14:75466010-75510579 (+)
DBA/2J MGP_DBA2J_G0021401
protein coding gene Chr14:67902718-67945122 (+)
FVB/NJ MGP_FVBNJ_G0021379
protein coding gene Chr14:67231550-67276479 (+)
LP/J MGP_LPJ_G0021471
protein coding gene Chr14:71220568-71265823 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021406
protein coding gene Chr14:74256994-74304691 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021996
protein coding gene Chr14:69819319-69864135 (+)
PWK/PhJ MGP_PWKPhJ_G0020570
protein coding gene Chr14:64639107-64681859 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020406
protein coding gene Chr14:65772078-65819687 (+)
WSB/EiJ MGP_WSBEiJ_G0020880
protein coding gene Chr14:70149806-70194325 (+)



Homology
more
  • Human Ortholog
    CPB2, carboxypeptidase B2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPB2, carboxypeptidase B2
  • Synonyms
    CPU, PCPB, TAFI
  • Links
    NCBI Gene ID: 1361
    neXtProt AC: NX_Q96IY4
    UniProt: Q96IY4

  • Chr Location
    13q14.13; chr13:46053186-46105033 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CPB2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit altered plasma clot lysis and may show reduced bleomycin-induced lung fibrosis, impaired healing of cutaneous wounds and colonic anastomoses, altered glomerular structure, or complement-mediated lethal inflammation after LPS sensitization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56373 NCBI Gene Model | MGI Sequence Detail 41269 C57BL/6J ±  kb
    transcript NM_019775 RefSeq | MGI Sequence Detail 1503 C57BL/6  
    polypeptide Q9JHH6 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 47
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915976, MGI:1923026, MGI:2145607
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:65056 Marx PF, et al., Characterization of mouse thrombin-activatable fibrinolysis inhibitor. Thromb Haemost. 2000 Feb;83(2):297-303
    • Latest
      J:320933 Basu S, et al., Role of thrombomodulin expression on hematopoietic stem cells. J Thromb Haemost. 2020 Jan;18(1):123-135

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory