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Cpb2 Gene Detail
Summary
  • Symbol
    Cpb2
  • Name
    carboxypeptidase B2 (plasma)
  • Synonyms
    1110032P04Rik, 4930405E17Rik, carboxypeptidase R, carboxypeptidase U, CPR, CPU, TAFI, thrombin-activatable fibrinolysis inhibitor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891837
    NCBI Gene: 56373
  • Gene Overview
    MyGene.info: CPB2
Location & Maps
more
  • Sequence Map
    Chr14:75242287-75283551 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41265 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 39.73 cM, cytoband D2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CPB2, carboxypeptidase B2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPB2, carboxypeptidase B2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPU, PCPB, TAFI
  • Links
    NCBI Gene ID: 1361
    neXtProt AC: NX_Q96IY4

  • Chr Location
    13q14.11; chr13:46053187-46105076 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    8
  • Genomic Mutations
    1 involving Cpb2
  • Incidental Mutations
Homozygous null mice exhibit altered plasma clot lysis and may show reduced bleomycin-induced lung fibrosis, impaired healing of cutaneous wounds and colonic anastomoses, altered glomerular structure, or complement-mediated lethal inflammation after LPS sensitization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021999 Ensembl Gene Model | MGI Sequence Detail 41265 C57BL/6J ±  kb
transcript ENSMUST00000022576 Ensembl | MGI Sequence Detail 1473 Not Applicable  
polypeptide ENSMUSP00000022576 Ensembl | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    213 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 48
    cDNA 46
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1915976, MGI:1923026, MGI:2145607
References
more
  • Summaries
    All 52
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:65056 Marx PF, et al., Characterization of mouse thrombin-activatable fibrinolysis inhibitor. Thromb Haemost. 2000 Feb;83(2):297-303
  • Latest
    J:230677 Byrnes JR, et al., Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin alpha-chain crosslinking. Blood. 2015 Oct 15;126(16):1940-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory